Cell adhesion induces the plasminogen activator inhibitor-1 gene expression through phosphatidylinositol 3-kinase/Akt activation in anchorage dependent cells

Cell Communication and Adhesion

Volumn 9, Issue 5-6, 2002, Pages 239-247

  Chang, Hang ^a   Shyu, Kou Gi ^b   Lin, Shankung ^b   Wang, Bao Wei ^b   Liu, Ya Chen ^b   Lee, Chun Chung ^b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Adhesion; Akt; PAI 1; PI 3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTISENSE OLIGODEOXYNUCLEOTIDE; COLLAGEN TYPE 1; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLASMINOGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN KINASE B; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE; WORTMANNIN;

ARTICLE; CELL ADHESION; CELL ANCHORAGE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE INDUCTION; GENETIC REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INHIBITION KINETICS; NORTHERN BLOTTING; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL ADHESION; ENZYME INHIBITORS; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMANS; OLIGONUCLEOTIDES, ANTISENSE; PEPTIDE HYDROLASES; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; TISSUE PLASMINOGEN ACTIVATOR; TUMOR CELLS, CULTURED; URINARY PLASMINOGEN ACTIVATOR;

EID: 0037774798     PISSN: 15419061     EISSN: None     Source Type: Journal    
DOI: 10.1080/15419060216303     Document Type: Article

References (25)

1. Aplin AE, Howe AK, Juliano RL (1999). Cell adhesion molecules, signal transduction and cell growth. Curr Opin Cell Biol 11: 737-744.
2. Banfi C, Eriksson P, Giandomenico G, Mussoni L, Sironi L, Hamsten A, Tremoli E (2001). Transcriptional regulation of plasminogen activator inhibitor type 1 gene by insulin: Insights into the signaling pathway. Diabetes 50: 1522-1530.
3. Conese M, Nykjaer A, Petersen CM, Cremona O, Pardi R, Andreasen PA, Gliemann J, Christensen EI, Blasi F (1995). Alpha-2 macroglobulin receptor/Ldl receptor-related protein (Lrp)-dependent internalization of the urokinase receptor. J Cell Biol 131: 1609-1622.
4. Cubellis MV, Wun TC, Blasi F (1990). Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1. EMBO J 9: 1079-1085.
5. Dedhar S (2000). Cell-substrate interactions and signaling through ILK. Curr Opin Cell Biol 12: 250-256.
6. Deng G, Curriden SA, Wang S, Rosenberg S, Loskutoff DJ (1996). Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release? J Cell Biol 134: 1563-1571.
7. Frisch SM, Screaton RA (2001). Anoikis mechanisms. Curr Opin Cell Biol 13: 555-562.
8. Giancotti FG, Ruoslahti E (1999). Integrin signaling. Science 285: 1028-1032.
9. Gorlach A, Diebold I, Schini-Kerth VB, Berchner-Pfannschmidt U, Roth U, Brandes RP, Kietzmann T, Busse R (2001). Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22 (phox)-containing NADPH oxidase. Circ Res 89: 47-54.
10. Kanse SM, Kost C, Wilhelm OG, Andreasen PA, Preissner KT (1996). The urokinase receptor is a major vitronectin-binding protein on endothelial cells. Exp Cell Res 224: 344-353.
11. Kjoller L, Kanse SM, Kirkegaard T, Rodenburg KW, Ronne E, Goodman SL, Preissner KT, Ossowski L, Andreasen PA (1997). Plasminogen activator inhibitor-1 represses integrin- and vitronectin-mediated cell migration independently of its function as an inhibitor of plasminogen activation. Exp Cell Res 232: 420-429.
12. Kobayashi N, Nakano S, Mita S, Kobayashi T, Honda T, Tsubokou Y, Matsuoka H (2002). Involvement of Rho-kinase pathway for angiotensin II-induced plasminogen activator inhibitor-1 gene expression and cardiovascular remodeling in hypertensive rats. J Pharmacol Exp Ther 301: 459-466.
13. Kutz SM, Hordines J, McKeown-Longo PJ, Higgins PJ (2001). TGF-beta 1-induced PAI-1 gene expression requires MEK activity and cell-to-substrate adhesion. J Cell Sci 114: 3905-3914.
14. Lee CC, Shyu KG, Lin S, Wang BW, Liu YC, Chang H (2002). Cell adhesion regulates the plasminogen activator inhibitor-1 gene expression in anchorage-dependent cells. Biochem Biophys Res Commun 291: 185-190.
15. Lin S, Huang HC, Chen LL, Lee CC, Huang TS (2001). GL331 induces down-regulation of cyclin D1 expression via enhanced proteolysis and repressed transcription. Molecular Pharmacology 60: 768-774.
16. Lopez S, Peiretti F, Morange P, Laouar A, Fossat C, Bonardo B, Huberman E, Juhan-Vague I, Nalbone G (1999). Activation of plasminogen activator inhibitor-1 synthesis by phorbol esters in human promyelocyte HL-60-roles of PCKbeta and MAPK p42. Thromb Haemost 81: 415-422.
17. Loskutoff KJ, Sawdey M, Mimuro J, Coller B (1989). Progress in Hemostasis and Thrombosis, 9th ed. pp. 87-115. W. B. Saunders, Philadelphia.
18. Maniatis T, Fritsch EF, Sambrook J (1982). Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY.
19. Nykjaer A, Conese M, Christensen EI, Olson D, Cremona O, Gliemann J, Blasi F (1997). Recycling of the urokinase receptor upon internalization of the uPA: Serpin complexes. EMBO J 16: 2610-2620.
20. Ryan MP, Kutz SM, Higgins PJ (1996). Complex regulation of plasminogen activator inhibitor type-1 (PAI-1) gene expression by serum and substrate adhesion. Biochem J 314: 1041-1046.
21. Schneiderman J, Loskutoff DJ (1991). Plasminogen activator inhibitors. Trends Cardiovasc Med 1: 99-102.
22. Schwartz MA, Schaller MD, Ginsberg MH (1995). Integrins: Emerging paradigms of signal transduction. Annu Rev Cell Dev Biol 11: 549-599.
23. Sprengers ED, Kluft C (1987). Plasminogen activator inhibitors. Blood 69: 381-387.
24. Stefansson S, Lawrence DA (1996). The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin. Nature 383: 441-443.
25. Takeda K, Ichiki T, Tokunou T, lino N, Fujii S, Kitabatake A, Shimokawa H, Takeshita A (2001). Critical role of Rhokinase and MEK/ERK pathways for angiotensin II-induced plasminogen activator inhibitor type-1 gene expression. Arterioscler Thromb Vasc Biol 21: 868-873.