Experimental hepatic uroporphyria induced by the diphenyl-ether herbicide fomesafen in male DBA/2 mice

Toxicology and Applied Pharmacology

Volumn 189, Issue 1, 2003, Pages 28-38

  Krijt, Jan ^a   Pšenák, Oskar ^a   Vokurka, Martin ^a   Chlumská, Alena ^a   Fakan, František ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

5 Aminolevulinic acid synthase; CYP1A2; CYP2B10; CYP4A10; Peroxidizing herbicides; Protoporphyrinogen oxidase; Uroporphyrinogen decarboxylase

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; ACIFLUORFEN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; DIPHENYL ETHER; FOMESAFEN; HERBICIDE; IRON; LIVER ENZYME; MESSENGER RNA; METHOXYRESORUFIN O DEALKYLASE; POLYCYCLIC AROMATIC HYDROCARBON; PORPHYRIN; PROTOPORPHYRINOGEN OXIDASE; UNCLASSIFIED DRUG; UROPORPHYRIN; UROPORPHYRINOGEN DECARBOXYLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INCLUSION; CONTROLLED STUDY; DIETARY INTAKE; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC CODE; HEPATIC UROPORPHYRIA; HISTOPATHOLOGY; HOUSEKEEPING GENE; LIVER CELL; LIVER LEVEL; LIVER MICROSOME; LIVER TOXICITY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; POLYMERASE CHAIN REACTION;

ANIMALIA;

EID: 0037723110     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(03)00087-5     Document Type: Article

References (42)

1. Akhtar R.A., Smith A.G. Chromosomal linkage analysis of porphyria in mice induced by hexachlorobenzene-iron synergism a model of sporadic porphyria cutanea tarda . Pharmacogenetics. 8:1998;485-494.
2. Birchfield N.B., Latli B., Casida J.E. Human protoporphyrinogen oxidase relation between the herbicide binding site and the flavin cofactor . Biochemistry. 37:1998;6905-6910.
3. Brumby P.E., Massey V. Determination of nonheme iron, total iron and copper. Eastabrook R.W., Pullman M.E. Methods in Enzymology. Vol. 10:1967;463-474 Academic Press, New York.
4. Constantin D., Francis J.E., Akhtar R.A., Clothier B., Smith A.G. Uroporphyria induced by 5-aminolaevulinic acid alone in Ahrd SWR mice. Biochem. Pharmacol. 52:1996;407-413.
5. Deam S., Elder G.H. Uroporphyria produced in mice by iron and δ-aminolevulinic acid. Biochem. Pharmacol. 41:1991;2019-2022.
6. Duke S.O. Overview of herbicide mechanisms of action. Environ. Health Perspect. 87:1990;263-271.
7. Elder G.H., Evans J.O., Matlin S.A. The effect of the porphyrogenic compound, hexachlorobenzene, on the activity of hepatic uroporphyrinogen decarboxylase in the rat. Clin. Sci. Mol. Med. 51:1976;71-80.
8. Fakan F., Chlumska A. Demonstration of needle-shaped hepatic inclusions in porphyria cutanea tarda using the ferric ferricyanide reduction test. Virchows Arch. A Pathol. Anat. Histopathol. 1987:1987;365-368.
9. Franklin M.R., Phillips J.D., Kushner J.P. CYP3A-inducing agents and the attenuation of uroporphyrin accumulation and excretion in a rat model of porphyria cutanea tarda. Biochem. Pharmacol. 60:2000;1325-1331.
10. Fraser D.J., Podvinec M., Kaufmann M.R., Meyer U.A. Drugs mediate the transcriptional activation of 5-aminolevulinic acid synthase (ALAS1) gene via the Chicken Xenobiotic-sensing Nuclear Receptor (CXR). J. Biol. Chem. 277:2002;34717-34726.
11. Goldstein J.A., Hickman P., Bergman H., Vos J.G. Hepatic porphyria induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse. Res. Commun. Chem. Pathol. Pharmacol. 6:1973;919-928.
12. Gorman N., Walton H.S., Bement W.J., Honsinger C.P., Szakacs J.G., Sinclair J.F., Sinclair P.R. Role of small differences in CYP1A2 in the development of uroporphyria produced by iron and 5-aminolevulinate in C57BL/6 and SWR strains of mice. Biochem. Pharmacol. 58:1999;375-382.
13. Greig J.B., Francis J.E., Kay S.J., Lovell D.P., Smith A.G. Incomplete correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin hepatotoxicity with Ah phenotype in mice. Toxicol. Appl. Pharmacol. 74:1984;17-25.
14. Hahn M.E., Gasiewicz T.A., Linko P., Goldstein J.A. The role of the Ah locus in hexachlorobenzene-induced porphyria studies in congenic C57BL/6 mice . Biochem. J. 254:1988;245-254.
15. Jacobs J.M., Sinclair P.R., Bement W.J., Lambrecht R.W., Sinclair J.F., Goldstein J.A. Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P450. Biochem. J. 258:1989;247-253.
16. Jones K.G., Sweeney G.D. Dependence of the porphyrogenic effect of 2,3,7,8-tetrachlorodibenzo(p)dioxin upon inheritance of aryl hydrocarbon hydroxylase responsiveness. Toxicol. Appl. Pharmacol. 53:1980;42-49.
17. Kappas A., Sassa S., Galbraith R.A., Nordmann Y. The porphyrias. Scriver C.R., Beandet A.L., Sly W.S., Valle D. The Metabolic and Molecular Basis of Inherited Disease. 1995;2103-2159 McGraw-Hill, New York.
18. Kawabata H., Germain R.S., Ikezoe T., Tong X., Green E.M., Gombart A.F., Koeffler H.P. Regulation of expression of murine transferrin receptor 2. Blood. 98:2001;1949-1954.
19. Krijt J., Stranska P., Sanitrak J. The effect of peroxidizing herbicides on porphyrin metabolism at low doses. Toxicol. Lett. 116:(Suppl. 1):2000;55.
20. Krijt J., Vokurka M., Sanitrak J., Janousek V., van Holsteijn I., Blaauboer B.J. Effect of the protoporphyrinogen oxidase-inhibiting herbicide fomesafen on liver uroporphyrin and heptacarboxylic porphyrin in two mouse strains. Food Chem. Toxicol. 32:1994;641-650.
21. Lambrecht R.W., Sinclair P.R., Gorman N., Sinclair J.F. Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2. Arch. Biochem. Biophys. 294:1992;504-510.
22. Matringe M., Camadro J.M., Labbe P., Scalla R. Protoporphyrinogen oxidase as a molecular target for diphenyl ether herbicides. Biochem. J. 260:1989;231-235.
23. Ockner R.K., Schmid R. Acquired porphyria in man and rat due to hexachlorobenzene intoxication. Nature. 189:1961;499.
24. Rimington C., Ziegler R. Experimental porphyria in rats induced by chlorinated benzenes. Biochem. Pharmacol. 12:1963;1387-1397.
25. Robinson S.W., Clothier B., Akhtar R.A., Yang A.L., Latour L., Van Ijperen C., Festing M.F., Smith A.G. Non-ahr gene susceptibility loci for porphyria and liver injury induced by the interaction of 'dioxin' with iron overload in mice. Mol. Pharmacol. 61:2002;674-681.
26. Rutten A.A., Falke H.E., Catsburg J.F., Wortelboer H.M., Blaauboer B.J., Doorn L., van Leeuwen F.X., Theelen R., Rietjens I.M. Interlaboratory comparison of microsomal ethoxyresorufin and pentoxyresorufin O-dealkylation determinations standardization of assay conditions . Arch. Toxicol. 66:1992;237-244.
27. Sanitrak J., Krijt J., Coupek J., Janousek V., Magnus I.A. Determination of porphyrins in tissue pre-adsorption followed by high-performance liquid chromatography . J. Chromatogr. 415:1987;129-135.
28. Seki Y., Kawanishi S., Sano S. Role of inhibition of uroporphyrinogen decarboxylase in PCB-induced porphyria in mice. Toxicol. Appl. Pharmacol. 90:1987;116-125.
29. Siersema P.D., Rademakers L.H., Cleton M.I., ten Kate F.J., de Bruijn W.C., Marx J.J., Wilson J.H. The difference in liver pathology between sporadic and familial forms of porphyria cutanea tarda the role of iron . J. Hepatol. 23:1995;259-267.
30. Sinclair P.R., Gorman N., Dalton T., Walton H.S., Bement W.J., Sinclair J.F., Smith A.G., Nebert D.W. Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice. Biochem. J. 330:1998;149-153.
31. Sinclair P.R., Gorman N., Walton H.S., Bement W.J., Dalton T.P., Sinclair J.F., Smith A.G., Nebert D.W. CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron. Toxicol. Appl. Pharmacol. 162:2000;60-67.
32. Smith A.G., Cabral J.R., De Matteis F. A difference between two strains of rats in their liver non-haem iron content and in their response to the porphyrogenic effect of hexachlorobenzene. Chem.-Biol. Interact. 27:1979;353-363.
33. Smith A.G., Francis J.E. Genetic variation of iron-induced uroporphyria in mice. Biochem. J. 291:1993;29-35.
34. Smith A.G., Clothier B., Carthew P., Childs N.L., Sinclair P.R., Nebert D.W., Dalton T.P. Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 173:2001;89-98.
35. Smith A.G., Francis J.E., Carthew P. Iron as a synergist for hepatocellular carcinoma induced by polychlorinated biphenyls in Ah-responsive C57BL/10ScSn mice. Carcinogenesis. 11:1990;437-444.
36. Smith A.G., Francis J.E., Walters D.G., Lake B.G. Protection against iron-induced uroporphyria in C57BL/10ScSn mice by the peroxisome proliferator nafenopin. Biochem. Pharmacol. 40:1990;2564-2568.
37. Smith L.L., Elcombe C.R. Mechanistic studies their role in the toxicological evaluation of pesticides . Food Addit. Contam. 6:(Suppl. 1):1989;S57-S65.
38. Strik J.J.T.W.A., Debets F.M.H. Chemical porphyria. Kimbrough R.D. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products. 1980;191-239 Elsevier/North Holland Biomedical Press, Amsterdam.
39. Sweeney G.D., Jones K.G., Cole F.M., Basford D., Krestynski F. Iron deficiency prevents liver toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Science. 204:1979;332-335.
40. van Gelder W., Siersema P.D., Voogd A., de Jeu-Jaspars N.C., van Eijk H.G., Koster J.F., de Rooy F.W., Wilson J.H. The effect of desferrioxamine on iron metabolism and lipid peroxidation in hepatocytes of C57BL/10 mice in experimental uroporphyria. Biochem. Pharmacol. 46:1993;221-228.
41. Wakabayashi K., Böger P. General physiological characteristics and mode of action of peroxidizing herbicides. Böger P., Wakabayashi K. Peroxidizing Herbicides. 1999;383-399 Springer, Berlin.
42. Yao C., Safe S. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced porphyria in genetically inbred mice partial antagonism and mechanistic studies . Toxicol. Appl. Pharmacol. 100:1989;208-216.