Rodent doxapram model of panic: Behavioral effects and c-Fos immunoreactivity in the amygdala

Biological Psychiatry

Volumn 53, Issue 10, 2003, Pages 863-870

  Sullivan, Gregory M ^a,c   Apergis, John ^b   Gorman, Jack M ^a   LeDoux, Joseph E ^b  

^a Columbia Univ Coll of Phys/Surgs ^*  (United States)

^b NEW YORK UNIVERSITY   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Amygdala; c Fos; Doxapram; Fear conditioning; Open field; Social interaction

Indexed keywords

DOXAPRAM; PROTEIN C FOS;

AMYGDALOID NUCLEUS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; ASSOCIATION; BRAIN FUNCTION; BRAIN NERVE CELL; BRAIN REGION; CELL ACTIVATION; CONDITIONING; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEAR; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NONHUMAN; OPEN FIELD TEST; PANIC; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; SOCIAL INTERACTION;

EID: 0037721660     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(02)01733-X     Document Type: Article

References (38)

1. Abelson J.L., Nesse R.M., Weg J.G., Curtis G.C. Respiratory psychophysiology and anxiety Cognitive intervention in the doxapram model of panic . Psychosom Med. 58:1996;302-313.
2. Abelson J.L., Weg J.G., Nesse R.M., Curtis G.C. Neuroendocrine responses to laboratory panic Cognitive intervention in the doxapram model . Psychoneuroendocrinology. 21:1996;375-390.
3. Anderson-Beck R., Wilson L., Brazier S., Hughes I.E., Peers C. Doxapram stimulates dopamine release from the intact rat carotid body in vitro. Neurosci Lett. 187:1995;25-28.
4. Bouton M.E., Mineka S., Barlow D.H. A modern learning theory perspective on the etiology of panic disorder. Psychol Rev. 108:2001;4-32.
5. Burki N.K. Ventilatory effects of doxapram in conscious human subjects. Chest. 85:1984;600-604.
6. Calverley P.M., Robson R.H., Wraith P.K., Prescott L.F., Flenley D.C. The ventilatory effects of doxapram in normal man. Clin Sci (Colch). 65:1983;65-69.
7. Commissaris R.L., Harrington G.M., Ortiz A.M., Altman H.J. Maudsley reactive and non-reactive rat strains Differential performance in a conflict task . Physiol Behav. 38:1986;291-294.
8. Cuccheddu T., Floris S., Serra M., Porceddu M.L., Sanna E., Biggio G. Proconflict effect of carbon dioxide inhalation in rats. Life Sci. 56:1995;L321-L324.
9. Davidson R.J., Irwin W. The functional neuroanatomy of emotion and affective style. Trends Cogn Sci. 3:1999;211-221.
10. Davis M., Whalen P.J. The amygdala Vigilance and emotion . Mol Psychiatry. 6:2001;13-34.
11. Di Lorenzo R., Bernardi M., Genedani S., Zirilli E., Grossi G., Guaraldi G.P., et al. Acute alkalosis, but not acute hypocalcemia, increases panic behavior in an animal model. Physiol Behav. 41:1987;357-360.
12. Flecknell P.A. Laboratory Animal Anesthesia: An Introduction for Research Workers and Technicians. 1987;Academic Press, San Diego.
13. Gorman J.M., Askanazi J., Liebowitz M.R., Fyer A.J., Stein J., Kinney J.M., et al. Response to hyperventilation in a group of patients with panic disorder. Am J Psychiatry. 141:1984;857-861.
14. Gorman J.M., Battista D., Goetz R.R., Dillon D.J., Liebowitz M.R., Fyer A.J., et al. A comparison of sodium bicarbonate and sodium lactate infusion in the induction of panic attacks. Arch Gen Psychiatry. 46:1989;145-150.
15. Gorman J.M., Fyer A.F., Gliklich J., King D., Klein D.F. Effect of sodium lactate on patients with panic disorder and mitral valve prolapse. Am J Psychiatry. 138:1981;247-249.
16. Gorman J.M., Kent J.M., Sullivan G.M., Coplan J.D. Neuroanatomical hypothesis of panic disorder, revised. Am J Psychiatry. 157:2000;493-505.
17. Grossen N.E., Kelley M.J. Species-specific behavior and acquisition of avoidance behavior in rats. J Comp Physiol Psychol. 81:1972;307-310.
18. Halgren E. Emotional neurophysiology of the amygdala within the context of human cognition. Aggleton J. The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction. 1992;191-228 Wiley-Liss, New York.
19. Halgren E., Babb T.L., Crandall P.H. Responses of human limbic neurons to induced changes in blood gases. Brain Res. 132:1977;43-63.
20. Harper R.M., Frysinger R.C., Trelease R.B., Marks J.D. State-dependent alteration of respiratory cycle timing by stimulation of the central nucleus of the amygdala. Brain Res. 306:1984;1-8.
21. Hatch R.C., Wilson R.C., Jernigan A.D., Clark J.D., Brown J. Reversal of thiopental-induced anesthesia by 4-aminopyridine, yohimbine, and doxapram in dogs pretreated with xylazine or acepromazine. Am J Vet Res. 46:1985;1473-1478.
22. LeDoux J.E. Emotion circuits in the brain. Annu Rev Neurosci. 23:2000;155-184.
23. Lee Y.J., Curtis G.C., Weg J.G., Abelson J.L., Modell J.G., Campbell K.M. Panic attacks induced by doxapram. Biol Psychiatry. 33:1993;295-297.
24. Liang K.C., McGaugh J.L., Yao H.Y. Involvement of amygdala pathways in the influence of post-training intra-amygdala norepinephrine and peripheral epinephrine on memory storage. Brain Res. 508:1990;225-233.
25. Menard J., Treit D. Effects of centrally administered anxiolytic compounds in animal models of anxiety. Neurosci Biobehav Rev. 23:1999;591-613.
26. Mitchell R.A., Herbert D.A. Potencies of doxapram and hypoxia in stimulating carotid-body chemoreceptors and ventilation in anesthetized cats. Anesthesiology. 42:1975;559-566.
27. Mizusawa A., Ogawa H., Kikuchi Y., Hida W., Kurosawa H., Okabe S., et al. In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia. J Physiol. 478:1994;55-66.
28. Nader K., Majidishad P., Amorapanth P., LeDoux J.E. Damage to the lateral and central, but not other, amygdaloid nuclei prevents the acquisition of auditory fear conditioning. Learn Mem. 8:2001;156-163.
29. Nishino T., Mokashi A., Lahiri S. Stimulation of carotid chemoreceptors and ventilation by doxapram in the cat. J Appl Physiol. 52:1982;1261-1265.
30. Olsson M., Ho H.P., Annerbrink K., Thylefors J., Eriksson E. Respiratory responses to intravenous infusion of sodium lactate in male and female Wistar rats. Neuropsychopharmacology. 27:2002;85-91.
31. Papp L.A., Klein D.F., Gorman J.M. Carbon dioxide hypersensitivity, hyperventilation, and panic disorder. Am J Psychiatry. 150:1993;1149-1157.
32. Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 4th ed :1998;Academic Press, San Diego.
33. Riddell P.L., Robertson G.S. Use of doxapram as an arousal agent in outpatient general anaesthesia. Br J Anaesth. 50:1978;921-924.
34. Roy R.C., Stullken E.H. Electroencephalographic evidence of arousal in dogs from halothane after doxapram, physostigmine, or naloxone. Anesthesiology. 55:1981;392-397.
35. Sanders S.K., Shekhar A. Regulation of anxiety by GABAA receptors in the rat amygdala. Pharmacol Biochem Behav. 52:1995;701-706.
36. Treit D., Fundytus M. Thigmotaxis as a test for anxiolytic activity in rats. Pharmacol Biochem Behav. 31:1988;959-962.
37. Williams C.L., Men D., Clayton E.C., Gold P.E. Norepinephrine release in the amygdala after systemic injection of epinephrine or escapable footshock Contribution of the nucleus of the solitary tract . Behav Neurosci. 112:1998;1414-1422.
38. Wolpe J., Rowan V.C. Panic disorder A product of classical conditioning . Behav Res Ther. 26:1988;441-450.