Side-effects of postoperative epidural analgesia in children: A randomized study comparing morphine and clonidine

Paediatric Anaesthesia

Volumn 13, Issue 4, 2003, Pages 318-323

  Cucchiaro, Giovanni ^a,b   Dagher, C ^a   Baujard, C ^a   Dubousset, A M ^a   Benhamou, D ^a  

^a BICÊTRE HOSPITAL   (France)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Children; Clonidine; Epidural; Morphine

Indexed keywords

CLONIDINE; MORPHINE; NALBUPHINE; ONDANSETRON; PROPOFOL; ROPIVACAINE; SEVOFLURANE; SUFENTANIL; THIOPENTAL;

ABDOMINAL SURGERY; ANESTHESIA INDUCTION; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG USE; EPIDURAL ANESTHESIA; EPIDURAL CATHETER; FEMALE; GENERAL ANESTHESIA; HUMAN; LOCAL ANESTHESIA; MALE; POSTOPERATIVE ANALGESIA; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SEDATION; SIDE EFFECT; VOMITING;

ABDOMEN; ANALGESIA, EPIDURAL; ANALGESICS; ANALGESICS, OPIOID; CHILD; CHILD, PRESCHOOL; CLONIDINE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MORPHINE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; TIME FACTORS;

EID: 0037715372     PISSN: 11555645     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9592.2003.01010.x     Document Type: Article

References (22)

1. Krane EJ, Jacobson LE, Lynn AM. Caudal morphine for postoperative analgesia in children: a comparison with caudal bupivacaine and intravenous morphine. Anesth Analg 1987; 66: 647-653.
2. Mayhew JF, Brodsky RC, Blakey D et al. Low-dose caudal morphine for postoperative analgesia in infant and children: a report of 500 cases. J Clin Anesth 1995; 7: 640-642.
3. Cook B, Grubb DJ, Aldrigde LA et al. Comparison of the effects of adrenaline, clonidine and ketamine on the duration of the caudal analgesia produced by bupivacaine in children. Br J Anaesth 1995; 75: 698-701.
4. De Negri P, Ivani G, Visconti C et al. The dose-response relationship of clonidine added to a postoperative continuous epidural infusion of ropivacaine in children. Anesth Analg 2001; 93: 71-76.
5. Lee JJ, Rubin AP. Comparison of bupivacaine-clonidine mixture with plain bupivacaine for caudal analgesia produced by bupivacaine in children. Br J Anaesth 1994; 72: 258-262.
6. De Kock Wiederkher P, Laghmiche A et al. Epidural clonidine used as the sole analgesic agent during and after abdominal surgery: a dose-response study. Anesthesiology 1997; 86: 285-292.
7. Gautier P, De Kock M, Van Steenberge A et al. A double-blind comparison of 0.125% ropivacaine with sufentanil and 0.125% with sufentanil for epidural labor analgesia. Anesthesiology 1999; 90: 772-778.
8. Narchi P, Benhamou D, Hamza J et al. Ventilatory effects of epidural clonidine during the first 3 hours after caesarean section. Acta Anaesthesiol Scand 1992; 36: 791-795.
9. Goodarzi M. Comparison of epidural morphine, hydromorphone and fentanyl for postoperative pain control in children undergoing orthopaedic surgery. Paed Anaesth 1999; 9: 412-422.
10. Wheatley RG, Madej TH, Jackson IJB et al. The first year's experience of an acute pain service. Br J Anaesth 1991; 67: 353-359.
11. Kiffer F, Joly A, Wodey E et al. The effect of preoperative epidural morphine on postoperative analgesia in children. Anesth Analg 2001; 93: 598-600.
12. White MJ, Berghausen EJ, Dumont SW et al. Side effects during continuous epidural infusion of morphine and fentanyl. Can J Anaesth 1992; 39: 576-582.
13. -1 for postoperative caudal analgesia in children. Eur J Anaesthesiol 1999; 16: 42-46.
14. Klimscha W, Chiari A, Michalek-Sauberer A et al. The efficacy and safety of a clonidine/bupivacaine combination in caudal blockade for pediatric hernia repair. Anesth Analg 1998; 86: 54-61.
15. Sharpe P, Klein JR, Thompson JP et al. Analgesia for circumcision in a paediatric population: comparison of caudal bupivacaine alone with bupivacaine plus two doses of clonidine. Paed Anaesth 2001; 11: 695-700.
16. De Kock M, Gautier P, Pavlopoulou A et al. Epidural clonidine of bupivacaine as the sole analgesic agent during and after abdominal surgery: a comparative study. Anesthesiology 1999; 90: 1354-1362.
17. Curatolo M, Schnider T, Petersen-Felix S et al. A direct search procedure to optimize combinations of epidural bupivacaine, fentanyl and clonidine for postoperative analgesia. Anesthesiology 2000; 92: 325-337.
18. van Essen EJ, Bovill JG, Ploeger EJ et al. Pharmacokinetics of clonidine after epidural administration in surgical patients. Lack of correlation between plasma concentration and analgesia and blood pressure changes. Acta Anaesthesiol Scand 1992; 36: 300-304.
19. Boswell G, Bekersky I, Mekki Q et al. Plasma concentration and disposition of clonidine following a constant 14-day epidural infusion in cancer patients. Clin Therapeut 1997; 19: 1024-1030.
20. Eisenach JC, De Kock M, Klimscha W. Alpha-2 adrenergic agonists for regional anesthesia: a clinical review of clonidine (1984-1995). Anesthesiology 1996; 85: 655-674.
21. Hama AT, Lloyd GK, Menzaghi F. The antinociceptive effect of intrathecal administration of epibatidine with clonidine or neostigmine in the formalin test in rats. Pain 2001; 91: 31-138.
22. Ivani G, Bergendhal HTG, Lampugnani E et al. Plasma levels of clonidine following epidural bolus injection in children. Acta Anaesthesiol Scand 1998; 42: 306-311.