Capillary electrophoretic separation and quantitation of ractopamine stereoisomers using cyclodextrins as chiral additives

Journal of Liquid Chromatography and Related Technologies

Volumn 26, Issue 11, 2003, Pages 1677-1693

  Inoue, Takayo ^a   Chang, Jen P ^a  

^a ELANCO ANIMAL HEALTH   (United States)

Author keywords

Capillary electrophoresis; Cyclodextrins; Multiple chiral centers; Ractopamine

Indexed keywords

ELECTROPHORESIS; EXTRACTION; ISOMERS; SEPARATION; STEREOCHEMISTRY;

CHIRAL SELECTORS;

AMINES;

CYCLODEXTRIN; HEPTAKIS(2,3 DIACETYL 6 SULFATO) BETA CYCLODEXTRIN; RACTOPAMINE; SULFATE; UNCLASSIFIED DRUG;

ARTICLE; CAPILLARY ELECTROPHORESIS; CHIRALITY; PH; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE; STEREOISOMERISM; VALIDATION PROCESS;

SUS SCROFA;

EID: 0037715302     PISSN: 10826076     EISSN: None     Source Type: Journal    
DOI: 10.1081/JLC-120021276     Document Type: Article

References (23)

1. Wozniak, T.J.; Bopp, R.J.; Jensen, E.C. Chiral drugs: an industrial analytical perspective. J. Pharm. Biomed. Anal. 1991, 9 (5), 363-382.
2. Gassmann, E.; Guo, J.E.; Zare, R.N. Electrokinetic separation of chiral compounds. Science 1985, 230 (4727), 813-814.
3. Rogan, M.M.; Altria, K.D.; Goodall, D.M. Enantioselective separations using capillary electrophoresis. Chirality 1994, 6, 25-40.
4. Terabe, S.; Otsuka, K.; Nishi, H. Separation of enantiomers by capillary electrophoretic techniques. J. Chromatogr. A 1994, 666 (1-2), 295-319.
5. Rizzi, A. Fundamental aspects of chiral separations by capillary electrophoresis. Electrophoresis 2001, 22 (15), 3079-3106.
6. Amini, A. Recent developments in chiral capillary electrophoresis and applications of this technique to pharmaceutical and biomedical analysis. Electrophoresis 2001, 22 (15), 3107-3130.
7. Terabe, S. Electrokinetic chromatography: an interface between electrophoresis and chromatography. Trends Anal. Chem. 1989, 8 (4), 129.
8. Fanali, S. Separation of optical isomers by capillary zone electrophoresis based on host-guest complexafion with cyclodextrins. J. Chromatogr. 1989, 474 (2), 441-446.
9. Chankvetadze, B.; Endresz, G.; Blaschke, G. About some aspects of the use of charged cyclodextrins for capillary electrophoresis enantioseparation. Electrophoresis 1994, 15, 804-807.
10. 13C NMR study of the chiral recognition mechanism. J. Chromatogr. A 1995, 717 (1-2), 245-253.
11. Tait, R.J.; Thompson, D.O.; Stobaugh, J.E Sulfobutyl ether β-cyclodextrin as a chiral discriminator for use with capillary electrophoresis. Anal. Chem. 1994, 66 (22), 4013-4018.
12. Vincent, J.B.; Sokolowski, A.D.; Nguyen, TV.; Vigh, G. A family of single-isomer chiral resolving agents for capillary electrophoresis. 1. Heptakis(2,3-diacetyl-6-sulfato)-β-cyclodextrin. Anal. Chem. 1997, 69 (20), 4226-4233.
13. Vincent, J.B.; Kirby, D.M.; Nguyen, T.V; Vigh, G. A family of single-isomer chiral resolving agents for capillary electrophoresis. 2. hepta-6-sulfato-β-cyclodextrin. Anal. Chem. 1997, 69 (21), 4419-4428.
14. Cai, H.; Nguyen, T.V.; Vigh, G. A family of single-isomer chiral resolving agents for capillary electrophoresis. 3. heptakis(2,3-dimethyl-6-sulfato)-β-cyclodextrin. Anal. Chem. 1998, 70 (3), 580-589.
15. Zhou, L.; Johnson, B.D.; Miller, C.; Wyvratt, J.M. Chiral capillary electrophoretic analysis of the enantiomeric purity of a pharmaceutical compound using sulfated β-cyclodextrin. J. Chromatogr. A 2000, 875 (1-2), 389-401.
16. Tamisier-Karolak, S.L.; Stenger, M.-A.; Bommart, A. Enantioseparation of β-blockers with two chiral centers by capillary electrophoresis using sulfated β-cyclodextrins. Electrophoresis 1999, 20 (13), 2656-2663.
17. Wang, F.; Khaledi, M.G. Capillary electrophoresis chiral separation of basic pharmaceutical enantiomers with different charges using sulfated β-cyclodextrin. J. Micro. Sep. 1999, 11 (1), 11-21.
18. Wang, F.; Dowling, T.; Bicker, G.; Wyvratt, J. Electrophoretic chiral separation of pharmaceutical compounds with multiple stereogenic centers in charged cyclodextrin media. J. Sep. Sci. 2001, 24 (5), 378-384.
19. New Animal Drugs for Use in Animal Feeds; Ractopamine Hydrochloride; Federal Register; Department of Health and Human Services, Food and Drug Administration: Washington, D.C., 2000; 4112-4121.
20. Watkins, L.E.; Jones, D.J.; Mowrey, D.H.; Anderson, D.B.; Veenhuizen, E.L. The effect of various levels of ractopamine hydrochloride on the performance and carcass characteristics of finishing swine. J. Anim. Sci. 1990, 68 (11), 3588-3595.
21. Stites, C.R.; McKeith, F.K.; Singh, S.D.; Bechtel, P.J.; Mowrey, D.H.; Jones, D.J. The effect of ractopamine hydrochloride on the carcass cutting yields of finishing swine. J. Anim. Sci. 1991, 69 (8), 3094-3101.
22. Ricke, E.A.; Smith, D.J.; Feil, V.J.; Larsen, G.L.; Caton, J.S. Effects of ractopamine HCl stereoisomers on growth, nitrogen retention, and carcass composition in rats. J. Anim. Sci. 1999, 77, 701-707.
23. Jorgenson, J.W.; Lukacs, K.D. Zone electrophoresis in open-tubular glass capillaries. Anal. Chem. 1981, 53, 1298-1302.