Systemic concentrations of antioxidants and biomarkers of macromolecular oxidative damage in horses with grass sickness

Equine Veterinary Journal

Volumn 35, Issue 2, 2003, Pages 121-126

  McGorum, B C ^a   Wilson, R ^b   Pirie, R S ^a   Mayhew, I G ^a   Kaur, H ^c   Aruoma, O I ^d  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

Antioxidants; Grass sickness; Horse; Oxidative stress

Indexed keywords

ANTIOXIDANT; BIOLOGICAL MARKER; CATECHOLAMINE; DOPA; FREE RADICAL; TYROSINE; FATTY ACID; PLANT TOXIN; TRACE ELEMENT; VITAMIN;

ACUTE PHASE RESPONSE; ARTICLE; CATECHOLAMINE SYNTHESIS; CONTROLLED STUDY; DISEASE MARKER; EQUINE GRASS SICKNESS; HORSE DISEASE; MACROMOLECULE; MALE; METABOLIC DISORDER; MOLECULAR DYNAMICS; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; ANIMAL; ANIMAL DISEASE; AUTONOMIC NEUROPATHY; BLOOD; CASE CONTROL STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORSE; PHYSIOLOGY; POACEAE;

EQUIDAE; EQUUS CABALLUS;

ANIMALS; ANTIOXIDANTS; AUTONOMIC NERVOUS SYSTEM DISEASES; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIHYDROXYPHENYLALANINE; FATTY ACIDS; FEMALE; HORSE DISEASES; HORSES; OXIDATIVE STRESS; PLANT POISONING; POACEAE; TRACE ELEMENTS; VITAMINS;

EID: 0037714017     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/042516403776114225     Document Type: Article

References (41)

1. Abe, A., Yamashita, S. and Noma, A. (1989) Sensitive, direct colorimetric assay for copper in serum. Clin. Chem. 35, 552-554.
2. Aruoma, O.I. (1994) Free radicals and antioxidant strategies in sports. J. Nutr. Biochem. 5, 370-381.
3. Aruoma, O.I. and Halliwell, B. (1998) Molecular Biology of Free Radicals in Human Diseases, OICA International, London.
4. Axelrod, F.B., Goldstein, D.S., Holmes, C., Berlin, D. and Kopin, I.J. (1996) Pattern of plasma levels of catecholamines in familial dysautonomia. Clin. Auton. Res. 6, 205-209.
5. Brubacher, G. and Vuilleumier, J.P. (1974) In: Clinical Biochemistry, Principles and Methods 2. Ed: H.C. Curtius, de Gruyter, Berlin, pp 989-997.
6. Burton, G.W., Joyce, A. and Ingold, K.U. (1983) Is vitamin E the only lipid soluble, chain breaking antioxidant in human blood plasma and erythrocyte membranes. Arch. Biochem. Biophys. 221, 281-290.
7. Cohen, G., Yakushin, S. and Dembiec-Cohen, D. (1998) Protein L-DOPA as an index of hydroxyl radical attack on protein tyrosine. Anal. Biochem. 263, 232-239.
8. Coyle, J.T. and Puttfarcken, P. (1993) Oxidative stress, glutamate and neurodegenerative diseases. Science 262, 689-695.
9. Dawson, V.L. and Dawson, T.M. (1996) Nitric-oxide neurotoxicity. J. Chem. Neuroanat. 10, 179-190.
10. Deiana, M., Aruoma, O.I., Rosa, A., Crobu, V., Casu, V., Rosaria, P. and Dessi, M.A. (2001) The effect of ferric-nitrilotriacetic acid on the profile of PUFA in the kidney and liver of rats. Toxicol. Lett. 123, 125-133.
11. Doxey, D.L., Milne, E.M., Gilmour, J.S. and Pogson, D.M. (1991) Clinical and biochemical features of grass sickness. Equine vet. J. 23, 360-364.
12. Ellman, G.E. (1959) Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82, 70-77.
13. Gieseg, S.P., Simpson, J.A., Charlton, T.S., Duncan, M.W. and Dean, R.T. (1993) Protein bound 3,4-dihydroxyphenylalanine is a major reductant formed during hydroxyl radical damage to proteins. Biochem. 32, 4780-4786.
14. Gopinathan, V., Miller, N.J., Milner, A.D. and RiceEvans, C.A. (1994) Bilirubin and ascorbate antioxidant activity in neonatal plasma. FEBS Lett. 349, 197-200.
15. Greig, J.R. (1942) Grass sickness in horses. Trans. High. Agric. Soc. Scot. 54, 3-27.
16. Grootveld, M. and Halliwell, B. (1987) Measurement of allantoin and uric acid in human body fluids. Biochem. J. 243, 803-808
17. Halliwell, B. and Kaur, H. (1997) Hydroxylation of salicylate and phenylalanine as assays for hydroxyl radicals: Free Rad. Res. 27, 239-244.
18. Hellesten, Y., Svensson, M., Sjodin, B., Smith, S., Christensen, A., Richter, E.A. and Bangsobo, J. (2001) Allantoin formation and urate and glutathione exchange in human muscle during submaximal exercise. Free Rad. Biol. Med. 31, 1313-1322.
19. Hudson, N.P., Wright, J.A. and Hunt, J. (1986) The sympatho-adrenal system and plasma-levels of adrenocorticotropic hormone, cortisol and catecholamines in equine grass sickness. Vet. Rec. 118, 148-150.
20. Hodson, N.P., Yeats, J., Wright, J.A. and Bloom, S.R. (1988) Plasma-levels of regulatory peptides (including insulin) in equine grass sickness and some other conditions. J. Path. 155, A346.
21. Hodson, N.P., Wright, J.A., Causon, R.C. and Hunt, J.M. (1989) Plasma and tissue histamine in equine grass sickness. J. vet Pharm. Ther. 12, 340-343.
22. Jennings, P.E., McLaren, M., Scott, N.A., Saniabadi, A.R. and Belch, J.J.F. (1991) The relationship of oxidative stress to thrombotic tendency in type-1 diabetic-patients with retinopathy. Diab. Med. 8, 860-865.
23. Jones, D.G., Suttle, N.F., Stevenson, L.M. and Hay, L. (1988) Observations on the diagnostic significance of plasma alpha-tocopherol estimation in goats. In: Animal Clinical Biochemistry, Ed: B.J. Blackmore, Cambridge University Press, Cambridge, pp 340-345.
24. Jungersten, L., Edlund, A., Petersson, A.S. and Wennmalm, A. (1996) Plasma nitrate as an index of nitric-oxide formation in man -analyses of kinetics and confounding factors. Clin. Physiol. 16, 369-379.
25. Kaneko, J.J. (1989) Blood analytes in large animals. In: Clinical Biochemistry of Domestic Animals. Ed: J.J. Kaneko. Academic Press, San Diego, p 891.
26. Kaur, H. and Halliwell, B. (1990) Action of biologically-relevant oxidising species upon uric acid. Chem. Biol. Interact. 73, 235-247.
27. Kaye, D.M., Wiviott, S.D., Kobzik, L., Kelly, R.A. and Smith, T.W. (1997) S-nitrosothiols inhibit neuronal norepinephrine transport. Am. J. Phys. 272, H875-883.
28. Luther, D.G., Cox, H.U. and Dimopoullos, G.T. (1981) Fatty-acid composition of equine plasma. Am. J. vet. Rex. 42, 91-93.
29. Lyras, L., Cairns, N.J., Jenner, A., Jenner, P.C. and Halliwell, B. (1997) An assessment of oxidative damage to proteins, lipids and DNA in brain from patients with Alzheimer's disease. J. Neurochem. 68, 2061-2069.
30. Maxwell, S.R.J. (1995) Prospects for the use of antioxidant therapies. Drugs 49, 345-361.
31. McGorum, B.C. and Kirk, J. (2001) Equine dysaulonomia is associated with altered plasma amino acid levels and depletion of plasma sulphur amino acids. Equine vet. J. 33, 473-477.
32. McGorum, B.C., Fry, S.C., Wallace, G., Coenen, K., Robb, J., Williamson, G. and Aruoma, O.I. (2000) Properties of herbage in relation to equine dysautonomia: biochemical composition, antioxidant and prooxidant actions. J. Agric. Fd. Chem. 48, 2346-2352.
33. McPherson, R. (1978) Selenium deficiency. Vet. Rec. 103, 60.
34. Miller, N.J., Johnston, J.D., Collis, C.S. and RiceEvans, C. (1997) Serum total antioxidant activity after myocardial infarction. Ann. Clin. Biochem. 34, 85-90.
35. Milne, E.M., Doxey, D.L. and Gilmour, J.S. (1990) Serum-lipids and lipoproteins in equine colic and grass sickness. Res. vet. Sci. 48, 170-174.
36. Milne, E.M., Doxey, D.L., Kent, J.E. and Pemberton, A. (1991) Acute phase proteins in grass sickness. Res. vet. Sci. 50, 273-278.
37. Rice-Evans, C. and Miller, N.J. (1994) Total antioxidant status in plasma and body-fluids. Meth. Enzymol. 234, 279-293.
38. Shenkin, A. (1995) Trace elements and inflammatory response: Implications for nutritional support. Nutrition 11, 100-105.
39. Simonian, N.A. and Coyle, J.T. (1996) Oxidative stress in neurodegenerative diseases. Ann. Rev. Pharmacol. Toxicol. 36, 83-106.
40. Wilkinson, J.H. (1966) Fluorometric determination of selenium in biological material with 2,3 diaminonaphthalene. Anal. Chem. 38, 92-97.
41. Wilson, R., Smith, R., Wilson, P., Shepherd, M.J. and Riemersma, R.A. (1997) Quantitative gas chromatography-mass spectroscopy isomer-specific measurement of hydroxy fatty acids in biological samples and food as a marker of lipid peroxidation. Anal. Biochem. 248, 76-85.