Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the human pancreas

Digestive Diseases and Sciences

Volumn 48, Issue 7, 2003, Pages 1230-1233

  Chrostek, Lech ^a   Jelski, Wojciech ^a   Szmitkowski, Maciej ^a   Puchalski, Zbigniew ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Alcohol dehydrogenase isoenzymes; Aldehyde dehydrogenase; Pancreas

Indexed keywords

ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; CYTOCHROME P450 2E1; FATTY ACID ESTER; ISOENZYME;

ADULT; ALCOHOL METABOLISM; ARTICLE; CLINICAL ARTICLE; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; FLUOROMETRY; HUMAN; HUMAN TISSUE; MALE; OXIDATION; PANCREAS; PANCREAS INJURY; PHOTOMETRY; PRIORITY JOURNAL;

ADULT; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ALDEHYDE OXIDOREDUCTASES; CULTURE TECHNIQUES; ETHANOL; FEMALE; HUMANS; ISOENZYMES; MALE; MIDDLE AGED; PANCREAS;

EID: 0037712152     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024134520823     Document Type: Article

References (20)

1. Laposata EA, Lange LG: Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse. Science 231:497-499, 1986
2. Hammamoto Y, Yamada S, Hirayama C: Nonoxidative metabolism of ethanol in the pancreas; implication in alcoholic pancreatic damage. Biochem Pharmacol 39:241-245, 1990
3. Werner J, Laposata M, Fernandez-del Castillo C, Saghir M, Iozzo RV, Lewndrowski KB, Warshaw AL: Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol. Gastroenterology 113:286-294, 1997
4. Haber PS, Apte MV, Applegate TL, Norton ID, Korsten MA, Pirola RC, Wilson JS: Metabolism of ethanol by rat pancreatic acinar cells. J Lab Clin Med 132:294-302, 1998
5. Boleda MD, Julia P, Moreno A, Pares X: Role of extrahepatic alcohol dehydrogenase in rat ethanol metabolism. Arch Biochem Biophys 274:74-81, 1989
6. Norton ID, Apte MV, Haber PS, McCanghan GW, Pirola RC, Wilson JS: Cytochrome P-4502E1 is present in rat pancreas and is induced by chronic ethanol administration. Gut 42:426-430, 1998
7. Werner J, Saghir M, Castillo CF, Warshaw AL, Laposata M: Linkage of oxidative and nonoxidative ethanol metabolism in the pancreas and toxicity of nonoxidative ethanol metabolites for pancreatic acinar cells. Surgery 129:736-744, 2001
8. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275, 1951
9. Wierzchowski J, Dafeldecker WP, Holmquist B, Vallee BL: Fluorimetric assay for isozymes of human alcohol dehydrogenase. Anal Biochem 178:57-62, 1989
10. Koivusalo M, Baumann M, Uotila L: Evidence for the identity of glutathionedependent formaldehyde dehydrogenase and class III alcohol dehydrogenase. FEBS Lett 257:105-109, 1989
11. Pestallozzi D, Buhler R, von Wartburg JP, Hess M: Immunohistochemical localization of alcohol dehydrogenase in the human gastrointestinal tract. Gastroenterology 85:1011-1016, 1983
12. Skursky L, Kovar J, Stachova M: A sensitive assay for alcohol dehydrogenase activity in blood serum. Anal Biochem 89:65-71, 1979
13. Wierzchowski J, Wroczynski P, Laszuk K, Interewicz E: Fluorimetric detection of aldehyde dehydrogenase activity in human blood, saliva, and organ biopsies and kinetic differentiation between class I and II isozymes. Anal Biochem 245:69-78, 1997
14. Estival A, Clemente F, Ribef A: Ethanol metabolism by the rat pancreas. Toxicol Appl Pharmacol 61:155-165, 1981
15. Julia P, Farres J, Pares X: Characterization of three isoenzymes of rat alcohol dehydrogenase. Tissue distribution and physical and enzymatic properties. Eur J Biochem 162:179-189, 1987
16. Julia P, Pares X, Jørnvall H: Rat liver alcohol dehydrogenase of class III. Primary structure, functional consequences and relationships to other alcohol dehydrogenases. Eur J Biochem 172:73-83, 1988
17. Bosron WF, Li T-K: Catalytic properties of human liver alcohol dehydrogenase isoenzymes. Enzyme 37:19-28, 1987
18. Jörnvall H, Höög J-O: Nomenclature of alcohol dehydrogenases. Alcohol Alcohol 30:153-161, 1995
19. Riveros-Rosas H, Julian-Sanchez A, Pina E: Enzymology of ethanol and acetaldehyde metabolism in mammals. Arch Med Res 28:453-471, 1997
20. Norton JD, Apte MV, Lux O, Haber PS, Pirola RC, Wilson JS: Chronic ethanol administration causes oxidative stress in the rat pancreas. J Lab Clin Med 131:442-446, 1998