An analysis of ISO intracutaneous reactivity test results to justify a reduction in animal requirements

Lab Animal

Volumn 32, Issue 3, 2003, Pages 26-27

  Upman, Paul J ^a   Anderson, Jason ^a   Tasse, Laura ^a  

^a NAMSA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POLYMER; VEGETABLE OIL; IRRITANT AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TESTING REDUCTION; ARTICLE; CALCULATION; CLINICAL FEATURE; CONTROLLED STUDY; DEVICE; DISEASE SEVERITY; EVALUATION; EXPERIMENTAL MODEL; FEASIBILITY STUDY; INJECTION; INJECTION SITE; INTRACUTANEOUS TEST; LIQUID; NONHUMAN; OUTCOMES RESEARCH; RABBIT; SCORING SYSTEM; SKIN IRRITATION; STANDARDIZATION; ANIMAL; ANIMAL WELFARE; CLASSIFICATION; DRUG EFFECT; DRUG SCREENING; INTERNATIONAL COOPERATION; INTRADERMAL DRUG ADMINISTRATION; METHODOLOGY; SKIN;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

ANIMAL WELFARE; ANIMALS; DRUG EVALUATION, PRECLINICAL; INJECTIONS, INTRADERMAL; INTERNATIONAL COOPERATION; INTRADERMAL TESTS; IRRITANTS; RABBITS; SKIN;

EID: 0037704195     PISSN: 00937355     EISSN: None     Source Type: Journal    
DOI: 10.1038/laban0303-26     Document Type: Article

References (4)

1. US Pharmacopeia 23/National Formulary 18 Part 87 (US Pharmacopeia Office, Rockville, MD, 2000).
2. Biological Evaluation of Medical Devices, Part 10: Tests for Irritation and Sensitization, ISO 10993-10 (AAMI, Arlington, VA, 1995).
3. Biological Evaluation of Medical Devices, Part 12: Sample Preparation and Reference Materials, ISO 10993-12 (AAMI, Arlington VA, 1996).
4. Draize, J.H. in Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics 46-59 (Association of Food and Drug Officials of the United States, Austin, TX, 1955).