Structural and functional cardiovascular abnormalities in never-treated hypertensives according to ACE-gene polymorphism

Journal of Human Hypertension

Volumn 17, Issue 6, 2003, Pages 441-443

  Ferrara, L A ^a   Guida, L ^a   Mangini, F P ^a   Celentano, A ^a   Niano, G D ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; DIPEPTIDYL CARBOXYPEPTIDASE; RENIN;

ADULT; ALDOSTERONE BLOOD LEVEL; ALLELE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE MONITORING; CARDIOVASCULAR DISEASE; CAROTID ARTERY; CLINICAL PROTOCOL; DISEASE SEVERITY; FEMALE; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HOMOZYGOSITY; HUMAN; HYPERTENSION; LETTER; MAJOR CLINICAL STUDY; MALE; MORPHOLOGY; PATHOLOGICAL ANATOMY; PLASMA RENIN ACTIVITY; POLYMERASE CHAIN REACTION; PROTEIN BLOOD LEVEL; QUESTIONNAIRE; SMOKING HABIT; SPHYGMOMANOMETER; STATISTICAL ANALYSIS; SYSTEMIC VASCULAR RESISTANCE;

ADULT; CARDIOVASCULAR ABNORMALITIES; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC;

EID: 0037704186     PISSN: 09509240     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jhh.1001560     Document Type: Letter

References (9)

1. Rigat B et al. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343-1346.
2. Higashimori K et al. Association analysis of a polymorphism of the angiotensin converting enzyme gene with essential hypertension in the Japanese population. Biochem Biophis Res Commun 1993; 191: 399-404
3. Kreutz R, Hübner N, Ganten D, Lindpaintner K. Genetic linkage of the ACE gene to plasma angiotensin-converting enzyme activity but not to blood pressure. A quantitative trait locus confers identical complex phenotypes in human and rat hypertension. Circulation 1995; 92: 2381-2384
4. Schunkert H et al. Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. N Engl J Med 1994; 330; 1634-1638
5. Lindpaintner K et al. Absence of association or genetic linkage between the angiotensin-converting-enzyme gene and left ventricular mass. N Engl J Med 1996; 334: 1023-1028
6. Castellano M et al. Angiotensin-converting-enzyme I/D polymorphism and arterial wall thickness in a general population - The Vobarno Study. Circulation 1995; 91: 2721-2724.
7. Ferrara LA et al. Isolated office hypertension and end-organ damage. J Hypertens 1997; 15: 979-985
8. Mancini FP et al. A fast and accurate method for genotyping the angiotensin converting enzyme I/D polymorphism. Circulation 1998; 97: 1213-1214.
9. Ferrara LA et al. Early changes of the arterial carotid wall in uncomplicated primary hypertensive patients. Arterioscler Thromb 1994; 14: 1290-1296.