JP-8 jet fuel exposure results in immediate immunotoxicity, which is cumulative over time

Toxicology and Industrial Health

Volumn 18, Issue 2, 2002, Pages 77-83

  Harris, David T ^a   Sakiestewa, Debbie ^a   Titone, Dominic ^a   Young, R Scott ^b   Witten, Mark ^b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

hydrocarbon inhalation; immunotoxicology; jet fuel; JP 8

Indexed keywords

FUEL;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL; BONE MARROW CELL; CELL COUNT; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CONVALESCENCE; DETERIORATION; FEMALE; IMMUNE FUNCTION TEST; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOTOXICITY; MOUSE; NONHUMAN; ORGAN WEIGHT; SPLEEN CELL; THYMUS; TIME; WEIGHT REDUCTION;

ANIMALS; BONE MARROW CELLS; CELL COUNT; FEMALE; FOSSIL FUELS; HYDROCARBONS; INHALATION EXPOSURE; LEUKOCYTES; MICE; MICE, INBRED C57BL; ORGAN SIZE; PETROLEUM; SPLEEN; THYMUS GLAND; TIME FACTORS;

ANIMALIA;

EID: 0037702515     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1191/0748233702th135oa     Document Type: Article

References (14)

1. Chen, H., Witten, M. L., Pfaff, J. K., Lantz, R. C. and Carter, D. 1992: JP-8 jet fuel exposure increases alveolar permeability in rats. FASEB Journal 6: A1064-A1064.
2. Dossing, M., Loft, S. and Schroeder, E. 1985: Jet fuel and liver function. Scandinavian Journal of Work and Environmental Health 11:433-437.
3. Gaworski, G., MacEwen, J., Vernot, E., Bruner, R. and Cowen, M. 1984: Comparison of the subchronic inhalation toxicity of petroleum and oil shale JP-5 jet fuel. In MacFarland, H. N. and Holdsworth, C. E. editors, Advances in Modern Environmental Toxicology, Volume 6. Princeton, NJ: Princeton Scientific Publishers, Inc., 33-47.
4. Harris, D. T., Schumacher, M. J., LoCascio, J., Besencon, F. J., Olson, G. B., DeLuca, D., Shanker, L., Bard, J. and Boyse, E. A. 1992: Phenotypic and functional immaturity of human umbilical cord blood T lymphocytes. Proceedings of the National Academy of Science, USA 89: 10006-10010.
5. Harris, D. T., Sakiestewa, D., Robledo, R. F. and Witten, M. 1997a: Immunotoxicological effects of JP-8 jet fuel exposure. Toxicology and Industrial Health 13: 43-55.
6. Harris, D. T., Sakiestewa, D., Robledo, R. F. and Witten, M. 1997b: Short-term exposure to JP-8 jet fuel results in longterm immunotoxicity. Toxicology and Industrial Health 13: 559-570.
7. Harris, D. T., Sakiestewa, D., Robledo, R. F., Young, R. C. and Witten, M. 2000: Effects of short term JP-8 jet fuel exposure on cell-mediated immunity. Toxicology and Industrial Health 16: 78-84.
8. Hays, A. M., Parliman, G., Pfaff, J. K., Lantz, R. C., Tinajero, J., Tollinger, B., Hall, J. N. and Witten, M. L. 1995: Changes in lung permeability correlates with lung histology in a chronic exposure model. Toxicology and Industrial Health 11: 325-326.
9. Mattie, D. R., Alden, C. L., Newell, T. K., Gaworski, C. L. and Flemming, CD. 1991: A 90-day continuous vapor inhalation toxicity study of JP-8 jet fuel followed by 20 or 21 months of recovery in Fischer 344 rats and C56BL/6 mice. Toxicology and Pathology 19: 77-87.
10. Pfaff, J., Parliman, G., Parton, K., Lantz, R., Chen, H., Hays, A., and Witten, M. 1993: Pathologic changes after JP-8 jet fuel inhalation in Fischer 344 rats. FASEB Journal 7: A408-A408.
11. Pfaff, J., Parton, K., Lantz, R. C., Chen, H., Hays, A. and Witten, M. L. 1995: Inhalation exposure to JP-8 jet fuel alters pulmonary function and substance P levels in Fischer 344 rats. Journal of Applied Toxicology 15: 249-256.
12. Struwe, G., Knave, B. and Mindus, P. 1983: Neuropsychiatric symptoms in workers occupationally exposed to jet fuel -a combined epidemiologic and causistic study. Acta Psychiatrica Scandinavica 303: 55-67.
13. Witten, M. L., Leeman, S. E., Lantz, R. C., Joseph, P. M., Burke, C. H., Jung, W. K., Quinn, D. and Hales, CA. 1990: Chronic jet fuel exposure increases lung substance P (SP) concentration in rabbits. In Leeman, S. E. editor, Substance P and related peptides: cellular and molecular physiology. International Symposium, University of Massachusetts and the New York Academy of Science, New York, 29-29.
14. Witten, M. L., Pfaff, J., Lantz, R. C., Parton, K. H., Chen, H., Hays, A. and Leeman, S. E. 1992: Capsaicin pretreatment before JP-8 jet fuel exposure causes a large increase in airway sensitivity to histamine in rats. Regulatory Peptides S1: S176-S176.