Oxidized low-density lipoprotein as a risk factor of thrombosis in antiphospholipid syndrome

Lupus

Volumn 12, Issue 7, 2003, Pages 550-554

  Matsuura, E ^a   Kobayashi, K ^a   Koike, T ^b   Shoenfeld, Y ^c   Khamashta, M A ^d   Hughes, G R V ^d  

^a OKAYAMA UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c SHEBA MEDICAL CENTER   (Israel)

^d ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

2 glycoprotein I; Antiphospholipid antibody; Antiphospholipid syndrome; Atherosclerosis; Oxidized LDL

Indexed keywords

7 KETOCHOLESTERYL 12 CARBOXYOCTADODECANOATE; 7 KETOCHOLESTERYL 9 CARBOXYNONANOATE; 7 KETOCHOLESTERYL ESTER; BETA2 GLYCOPROTEIN 1; BETA2 GLYCOPROTEIN 1 ANTIBODY; CARBOXYL GROUP; CARDIOLIPIN ANTIBODY; ESTER DERIVATIVE; LIGAND; OXIDIZED LOW DENSITY LIPOPROTEIN; SCHIFF BASE; UNCLASSIFIED DRUG;

ANTIPHOSPHOLIPID SYNDROME; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR RISK; CONFERENCE PAPER; HUMAN; IMMUNE RESPONSE; LYMPHOCYTE; MACROPHAGE; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RISK FACTOR; THROMBOSIS;

ANTIGEN-ANTIBODY COMPLEX; ANTIPHOSPHOLIPID SYNDROME; ARTERIOSCLEROSIS; AUTOANTIBODIES; AUTOIMMUNITY; BETA 2-GLYCOPROTEIN I; GLYCOPROTEINS; HUMANS; LIGANDS; LIPOPROTEINS, LDL; OXIDATION-REDUCTION; RISK FACTORS; THROMBOSIS;

EID: 0037700593     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1191/0961203303lu400oa     Document Type: Conference Paper

References (5)

1. Tinahones FJ, Cuadrado MJ, Khamashta MA et al. Lack of cross-reaction between antibodies to β2-glycoprotein-I and oxidized low-density lipoprotein in patients with antiphospholipid syndrome. Br J Rheumatol 1998; 37: 746-749.
2. Romero FI, Amengual O, Atsumi T, Khamashta MA, Tinahones FJ, Hughes GRV. Arterial disease in lupus and secondary antiphospholipid syndrome: association with anti-β2-glycoprotein I antibodies but not with antibodies against oxidized low-density lipoprotein. Br J Rheumatol 1998; 37: 883-888.
3. Kobayashi K, Matsuura E, Liu Q et al. A specific ligand for β2-glycoprotein I mediates autoantibody-dependent uptake of oxidized low density lipoprotein by macrophages. J Lipid Res 2001; 42: 697-709.
4. Liu Q, Kobayashi K, Furukawa JI et al. ω-Carboxyl variants of 7-ketocholesteryl esters are ligands for β2-glycoprotein I and mediate anfibody-dependent uptake of oxidized LDL by macrophages. J Lipid Res 2002; 43: 1486-1495.
5. George J, Harats D, Gilburd B et al. Immunolocalization of β2-glycoprotein I (apolipoprotein H) to human atherosclerotic plaques: potential implications for lesion progression. Circulation 1999; 99: 2227-2230.