Effect-site concentration of propofol for recovery of consciousness is virtually independent of fentanyl effect-site concentration

Anesthesia and Analgesia

Volumn 96, Issue 6, 2003, Pages 1651-1655

  Iwakiri, Hiroko ^a   Nagata, Osamu ^a   Matsukawa, Takashi ^b   Ozaki, Makoto ^a   Sessler, Daniel I ^c,d  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF YAMANASHI   (Japan)

^c Outcomes Research Institute   (United States)

^d UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; FENTANYL; HYDROXYZINE; NEOSTIGMINE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PROPOFOL; VECURONIUM;

ADULT; ANESTHESIOLOGICAL TECHNIQUES; ANESTHETIC RECOVERY; AROUSAL; ARTICLE; BRADYCARDIA; BREATHING RATE; CARDIOTOXICITY; CLINICAL ARTICLE; CONSCIOUSNESS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; FEMALE; GYNECOLOGIC SURGERY; HEART RATE; HUMAN; HYPOTHESIS; HYPOVENTILATION; LAPAROTOMY; LUNG TOXICITY; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZATION;

EID: 0037686526     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000062772.28479.2B     Document Type: Article

References (20)

1. Kazama T, Ikeda K, Morita K. Reduction by fentanyl of the Cp50 values of propofol and hemodynamic responses to various noxious stimuli. Anesthesiology 1997;87:213-27.
2. Smith C, McEwan AI, Jhaveri R, et al. The interaction of fentanyl on the Cp50 of propofol for loss of consciousness and skin incision. Anesthesiology 1994;81:820-8.
3. Telford RJ, Glass PS, Goodman D, Jacobs JR. Fentanyl does not alter the "sleep" plasma concentration of thiopental. Anesth Analg 1992;75:523-9.
4. Nagata O, Sawada K, Sato M, et al. [Evaluation of estimated blood concentration of propofol on wake-up using "ConGrase", a software to control the syringe pump for propofol infusion]. Masui 1998;47:1246-52.
5. Marsh B, White M, Morton N, Kenny GN. Pharmacokinetic model driven infusion of propofol in children. Br J Anaesth 1991;67:41-8.
6. Shafer SL, Varvel JR, Aziz N, Scott JC. Pharmacokinetics of fentanyl administered by computer-controlled infusion pump. Anesthesiology 1990;73:1091-102.
7. Benett WRJ. Scientific and engineering problem-solving with the computer. Englewood Cliffs, NJ: Prentice Hall, 1976.
8. Eger EI II. MAC, MAP, and euphony. Anesthesiology 1971;35:552.
9. Leslie K, Sessler DI, Smith WD, et al. Prediction of movement following painful stimulation during propofol/nitrous oxide anesthesia in volunteers. Anesthesiology 1996;84:52-63.
10. Leslie K, Sessler DI, Schroeder M, Walters K. Propofol blood concentration and the bispectral index predict suppression of learning during propofol/epidural anesthesia in volunteers. Anesth Analg 1995;81:1269-74.
11. Doufas AG, Bakhshandeh M, Bjorksten AR, et al. Automated responsiveness test (ART) predicts loss of consciousness and adverse physiologic responses during propofol conscious sedation. Anesthesiology 2001;94:585-92.
12. Roizen MF, Horrigan RW, Frazer BM. Anesthetic doses blocking adrenergic (stress) and cardiovascular responses to incision: MAC BAR. Anesthesiology 1981;54:390-8.
13. 95 propofol-opioid concentrations that assure adequate anesthesia and a rapid return of consciousness. Anesthesiology 1997;87:1549-62.
14. Katoh T, Suguro Y, Kimura T, Ikeda K. Morphine does not affect the awakening concentration of sevoflurane. Can J Anaesth 1993;40:825-8.
15. Katoh T, Uchiyama T, Ikeda K. Effect of fentanyl on awakening concentration of sevoflurane. Br J Anaesth 1994;73:322-5.
16. Splinter WM, Cervenko F. Haemodynamic responses to laryngoscopy and tracheal intubation in geriatric patients: effects of fentanyl, lidocaine and thiopentone. Can J Anaesth 1989;36:370-6.
17. Bowdle TA, Ward RJ. Induction of anesthesia with small doses of sufentanil or fentanyl: dose versus EEG response, speed of onset, and thiopental requirement. Anesthesiology 1989;70:26-30.
18. Mildh LH, Scheinin H, Kirvela OA. The concentration-effect relationship of the respiratory depressant effects of alfentanil and fentanyl. Anesth Analg 2001;93:939-46.
19. Woodhouse A, Mather LE. The minimum effective concentration of opioids: a revisitation with patient controlled analgesia fentanyl. Reg Anesth Pain Med 2000;25:259-67.
20. Gourlay GK, Kowalski SR, Plummer JL, et al. Fentanyl blood concentration-analgesic response relationship in the treatment of postoperative pain. Anesth Analg 1988;67:329-37.