The use of dinoflagellate bioluminescence to characterize cell stimulation in bioreactors

Biotechnology and Bioengineering

Volumn 83, Issue 1, 2003, Pages 93-103

  Chen, Antony K ^a   Latz, Michael I ^b   Frangos, John A ^a,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LA JOLLA BIOENGINEERING INSTITUTE   (United States)

Author keywords

Bioluminescence; Bioreactor; Dinoflagellate; Pyrocystis; Shear; Temporal gradients

Indexed keywords

BIOREACTORS; CELL CULTURE; HYDRODYNAMICS; MASS TRANSFER; SHEAR STRESS;

HYDRODYNAMIC FORCES;

BIOLUMINESCENCE;

ANIMAL CELL; ARTICLE; BIOLUMINESCENCE; BIOREACTOR; CELL ACTIVATION; CELL DAMAGE; CELL GROWTH; CELL STIMULATION; DINOFLAGELLATE; HYDRODYNAMICS; NONHUMAN; SHEAR STRESS;

NON-PROGRAMMATIC;

ACCELERATION; ANIMALS; BIOREACTORS; BIOSENSING TECHNIQUES; DINOFLAGELLIDA; LUMINESCENCE; MECHANOTRANSDUCTION, CELLULAR; MOTION; PHYSICAL STIMULATION; RHEOLOGY; SHEAR STRENGTH; STRESS, MECHANICAL;

DINOPHYCEAE; PYROCYSTIS;

EID: 0037677429     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10647     Document Type: Article

References (55)

1. Aloi LE, Cherry RS. 1996. Cellular response to agitation characterized by energy dissipation at the impeller tip. Chem Eng Sci 51:1523-1529.
2. Augenstein DC, Sinskey AJ, Wang DIC. 1971. Effects of shear on the death of two strains of mammalian tissue cells. Biotechnol Bioeng 13:409-418.
3. Bao X, Clark CB, Frangos JA. 2000. Temporal gradient in shear-induced signaling pathway: involvement of MAP kinase, c-fos, and connexin43. Am J Physiol Heart Circ Physiol 278:1598-1605.
4. Bao X, Lu C, Frangos JA. 1999. Temporal gradient in shear but not steady shear stress induces PDGF-A and MCP-1 expression in endothelial cells: role of NO, NF κB, and egr-1. Arterioscler Thromb Vasc Biol 19:996-1003.
5. Bao X, Lu C, Frangos JA. 2001. Mechanism of temporal gradients in shear-induced ERK1/2 activation and proliferation in endothelial cells. Am J Physiol Heart Circ Physiol 281:22-29.
6. Biggley WH, Swift E, Buchanan RJ, Seliger HH. 1969. Stimulable and spontaneous bioluminescence in the marine dinoflagellates, Pyrodinium bahamense, Gonyaulaz polyedra, and Pyrocystis lunula. J Gen Physiol 54:96-122.
7. Bityukov EP. 1971. Bioluminescence in the wake current in the Atlantic Ocean and Mediterranean Sea. Ocean 11:127-133.
8. Bliem R, Katinger H. 1988a. Scale-up engineering in animal cell technology part I. Trends Biotechnol 6:190-195.
9. Bliem R, Katinger H. 1988b. Scale-up engineering in animal cell technology part II. Trends Biotechnol 6:224-230.
10. Cherry RS, Papoutsakis ET. 1986. Hydrodynamic effects on cells in agitated tissue culture reactors. Bioproc Eng 1:29-41.
11. Cherry RS, Papoutsakis ET. 1988. Physical mechanisms of cell damage in microcarrier cell culture bioreactors. Biotechnol Bioeng 32: 1001-1014.
12. Cherry RS, Papoutsakis ET. 1989. Growth and death rates of bovine embryonic kidney cells in turbulent microcarrier bioreactors. Bioproc Eng 4:81-89.
13. Croughan MS, Wang DIC. 1989. Growth and death in overagitated microcarrier cell cultures. Biotechnol Bioeng 33:731-744.
14. Croughan MS, Hamel JF, Wang DIC. 1987. Hydrodynamic effects on animal cells grown in microcarrier cultures. Biotechnol Bioeng 29: 130-141.
15. Dewey CF Jr. 1984. Effects of fluid flow on living vascular cells. J Biomech Eng 196:31-35.
16. Eckert R. 1965. Bioelectric control of bioluminescence in the dinoflagellate Noctiluca. Science 147:1140-1145.
17. Frangos JA, Eskin SG, McIntire LV, Ives CL. 1985. Flow effects on prostacyclin production by cultured human endothelial cells. Science 227:1477-1479.
18. Frangos JA, Huang TY, Clark CB. 1996, Steady shear and step changes in shear stimulate endothelium via independent mechanisms Superposition of transient and sustained nitric oxide production. Biochem Biophys Res Commun 224:660-665.
19. Gregoriades N, Clay J, Ningning M, Koelling K, Chalmers JJ. 2000. Cell damage of microcarrier cultures as a function of local energy dissipation created by a rapid extensional flow. Biotechnol Bioeng 69: 171-182.
20. Guillard RRL, Ryther JH. 1962. Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (Cleve) Gran, Can. J Microbiol 8:229-239.
21. Hardy AC. 1956. The open sea it's natural history: the world of plankton. London: Collins.
22. Hu WS. 1984. Quantitative and mechanistic analysis of mammalian cell cultivation on microcarriers. Ph.D. dissertation, Massachusetts Institute of Technology, Cambridge, MA.
23. Kunas KT, Papoutsakis ET. 1990. Damage mechanisms of suspended animal cells in agitated bioreactors with and without bubble entrainment. Biotechnol Bioeng 36:476-483.
24. Lakhotia S, Papoutsakis ET. 1992. Agitation induced cell injury in microcarrier cultures. The protective effect of viscosity is agitation-intensity dependent: experiments and modeling. Biotechnol Bioeng 39:95-107.
25. Latz MI, Lee AO. 1995. Spontaneous and stimulated bioluminescence in the dinoflagellate, Ceratocorys horrida. J Phycol 31:120-132.
26. Latz MI, Rohr J. 1999. Luminescent response of the red tide dinoflagellate Lingulodinium polyedrum to laminar and turbulent flow. Limnol Oceanogr 44:1423-1435.
27. Latz MI, Case JF, Gran RL. 1994. Excitation of bioluminescence by laminar fluid shear associated with simple Couette flow. Limnol Oceanogr 39:1424-1439.
28. Leckie F, Scragg AH, Cliffe KC. 1991. Effect of bioreactor design and agitator speed on the growth and alkaloid accumulation by cultures of Catharanthus roseus. Enzyme Microb Technol 13:296-305.
29. Mallipattu SK, Haidekker MA, von Dassow P, Latz MI, Frangos JA. 2002. Evidence for shear-induced increase in membrane fluidity in the dinoflagellate Lingulodinium polyedrum. J Comp Physiol 188:409-416.
30. McIntire LV, Frangos JA, Eskin SG, Hall ER. 1987. Effects of hemodynamic shear on arachidonic acid metabolism in vascular endothelium. In: Hartmann A, editor. Cerebral ischemia and hemorheology. Berlin: Springer-Verlag p 280-289.
31. Morin JG. 1983. Coastal bioluminescence: patterns and functions. Bull Mar Sci 33:787-817.
32. Nagata S. 1975. Mixing principle and applications. Japan and New York: Kodansha Ltd and Halsted Press.
33. O'Connor KC, Papoutsakis ET. 1992. Agitation effects on microcarrier and suspension CHO cells. Biotechnol Techn 6:323-328.
34. Papoutsakis ET. 1991. Fluid-mechanical damage of animal cells in bioreactors (A review). Trends Biotechnol 9:427-437.
35. Papoutsakis ET, Michaels JD. 1993. Physical forces in mammalian cell bioreactors. In: Frangos JA, editor. Physical forces and the mammalian cells. New York: Academic Press. p 291-345.
36. Peters F, Redondo JM. 1997. Turbulence generation and measurement: application to studies on plankton. Sci Mar 61:205-228.
37. Petersen JF, McIntire LV, Papoutsakis ET. 1988. Shear sensitivity of cultured hybridoma cells (CRL-8018) depends on mode of growth, culture age and metabolite concentration. J Biotechnol 7:229-246.
38. Petersen JF, McIntire LV, Papoutsakis ET. 1990 Shear sensitivity of freely suspended animal cells in batch, fedbatch, and continuous cultures. Biotechnol Progr 6:114-120.
39. Rhee BG, McIntire LV, 1986. Effect of shear stress on platelet-PMN leukocyte interaction. Chem Eng Commun 47:147-161.
40. Riet KV. 1979. Review of measuring methods and results in nonviscous gas-liquid mass transfer in stirred vessels. Ind Eng Chem Proc Des Dev 18:357-364.
41. Riet KV, Smith JM. 1975. The trailing vortex system produced by Rushton turbine agitators. Chem Eng Sci 30:1093-1105.
42. Rohr JJ, Losee JR, Hoyt JW. 1990, Stimulation of bioluminescence by turbulent pipe flow. Deep-Sea Res 37:1639-1646.
43. Rohr J, Hyman J, Fallon S, Latz, MI. 2002. Bioluminescence flow visualization in the ocean: an initial strategy based on laboratory experiments. Deep-Sea Res 49:2009-2033.
44. Rohr JJ, Latz MI, Fallon S, Nauen JC, Hendricks E. 1998. Experimental approaches towards interpreting dolphin-stimulated bioluminescence, J Exp Biol 201:1447-1460.
45. Schmidtke NW, Horvath J. 1977. Scale-up methodology for surface aerated reactors. Prog Wat Tech 9:477.
46. Sinskey AJ, Fleischaker M, Tyo MA, Giard DJ, Wang DIC. 1981. Production of cell-derived products: virus and interferon. Ann NY Acad Sci 369:47-59.
47. Sweeney BM. 1981. Variations in the bioluminescence per cell in dinolagellates. In: Nealson KH, editor. Bioluminescence current perspectives. Minneapolis: p 90-94.
48. Venkat VR, Chalmers JJ. 1996. Characterization of agitation environments in 250ml spinner vessel, 3L, and 20L reactor vessels used for animal cell microcarrier culture. Cytotechnol 22:95-102.
49. Venkat VR, Stock LR, Chalmers JJ. 1996. Study of hydrodynamics in microcarrier culture spinner vessels: a particle tracking velocimetry approach. Biotechnol Bioeng 49:456-466.
50. White CR, Haidekker M, Bao X, Frangos JA. 2001. Temporal gradients in shear, but not spatial gradients, stimulate endothelial cell proliferation. Circulation 103:2508-2513.
51. Widder EA, Case JF. 1981a. Bioluminescence excitation in dinoflagellates. In: Nealson KH, editor. Bioluminescence current perspectives. Minneapolis: p 125-132.
52. Widder EA, Case JF. 1981b. Two flash forms in the dinoflagellates, Pyrocystis fusiformis. J Comp Physiol 143:43-52.
53. Wilson T, Hastings JW. 1998. Bioluminescence. Ann Rev Cell Dev Biol 14:197-230.
54. Wu H, Patterson GK. 1989. Laser-Doppler measurements of turbulent-flow parameters in a stirred mixer. Chem Eng Sci 44:2207-2221.
55. Yianneskis M, Popiolek Z, Whitelaw JH. 1987. An experimental study of the steady and unsteady flow characteristics of stirred reactors. J Fluid Mech 175:537-555.