Synthesis, structural, conformational and pharmacological study of esters derived from 3-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9α-ol as potential analgesics

Journal of Physical Organic Chemistry

Volumn 11, Issue 2, 1998, Pages 125-132

  Iriepa, I ^a   Gil Alberdi, B ^a   Galvez, E ^a   Sanz Aparicio, J ^b   Fonseca, I ^b   Orjales, A ^c   Berisa, A ^c   Labeaga, C ^c  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^c Departamanto de Investigacion   (Spain)

Author keywords

3 methyl 2, 4 diphenyl 3 azabicyclo 3.3.1 nonan 9 ol esters; Analgesics; Conformation; Pharmacological assays; Structure; Synthesis

Indexed keywords

EID: 0037671661     PISSN: 08943230     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1099-1395(199802)11:2<125::aid-poc979>3.0.co;2-%23     Document Type: Article

References (25)

1. M. J. Fernández, R. M. Huertas, E. Gálvez, A. Orjales, A. Berisa, L. Labeaga, F. Gago, I. Fonseca, J. Sanz-Aparicio, F. H. Cano, A. Albert and J. Fayos. J. Chem. Soc, Perkin Trans. 2 687 (1992).
2. P. A. J. Janssen. US pat. 3 600 164 (1965).
3. I. Iriepa, B. Gil-Alberdi and E. Gálvez. J. Heterocycl. Chem. 29, 519 (1992).
4. A. Hassner and V. Alexanian. Tetrahedron Lett. 46, 4475 (1978).
5. P. Main, S. J. Fiske, S. E. Hull, L. Lessinger, G. Germain, J. P. Declercq and M. M. Woolfson. MULTAN 80. A System of Computer Programs for Automatic Solution of Crystal Structures from X-Ray Diffraction Data. Universities of York and Louvain (1980).
6. S. R. Hall and J. M. Stewart. XTTAL System. Universities of Western Australia and Maryland (1990).
7. M. Martínez-Ripoll and F. H. Cano. PESOS. A Computer Program for the Automatic Treatment of Weighting Scheme. Instituto Rocasolano, CSIC, Madrid (1975).
8. J. M. Stewart, F. A. Kundell and J. C. Baldwin. The XRAY80 System of Crystallographic Programs. Computer Science Center, University of Maryland, College Park, MD (1980).
9. I. Vickovic. CSU. A Program for the Calculation and Presentation of Geometrical Parameters. University of Zagreb (1988).
10. M. Nardelli. Comput. Chem. 7, 95 (1983).
11. International Tables for X-Ray Crystallography, Vol. 4. Kynoch Press, Birmingham (1974).
12. W. D. S. Motherwell and W. Clegg. PLUTO. A Program for Plotting Molecular and Crystal Structures. University of Cambridge (1978).
13. A. Albert and F. H. Cano. CONTACTOS. A Computer Program to Study Interactions Between Phenyl Rings. Instituto Rocasolano, CSIC, Madrid (1991).
14. M. S. Arias, E. Gálvez, I. Ardid, J. Bellanato, J. V. García-Ramos, F. Florencio and S. García-Blanco. J. Mol. Struct. 161, 151(1987).
15. E. Gálvez, M. S. Arias, F. Florencio, J. Sanz-Aparicio, J. Bellanato and J. V. García-Ramos. J. Mol. Struct. 196, 307 (1989).
16. E. Gálvez, M. S. Arias, I. Ardid, J. Bellanato and J. V. García-Ramos. J. Mol. Struct. 174, 223 (1988).
17. M. L. Izquierdo, M. S. Arias, E. Gálvez, B. Rico, I. Ardid, J. Sanz-Aparicio, I. Fonseca, A. Orjales and A. Innerarity. J. Pharm. Sci. 80, 554 (1991).
18. I. Iriepa, A. Lorente, M. S. Arias, E. Gálvez, F. Florencio and J. Sanz-Aparicio. J. Mol. Struct. 174, 273 (1988).
19. I. Iriepa, M. S. Arias, A. Lorente, E. Gálvez, F. Florencio and J. Sanz-Aparicio. J. Mol. Struct. 192, 15 (1989).
20. C. A. G. Haasnoot, F. A. A. M. de Leeuw and C. Altona. Tetrahedron 36, 2783 (1980).
21. R. Jeyaraman, C. B. Jawaharsingh, S. Avila, E. L. Eliel, M. Manoharan and S. Morris-Natschke. J. Heterocycl. Chem. 19, 449 (1982).
22. E. Gálvez, M. S. Arias, J. Bellanato, J. Bellanato, J. V. García-Ramos, F. Florencio, P. Smith-Verdier and S. García-Blanco. J. Mol. Struct. 127, 185 (1985).
23. R. Koster, H. Anderson and J. De Beer. Fed. Proc. Fed. Am. Soc. Exp. Biol. 18, 412 (1959).
24. P. H. J. Janssen and A. H. Jageneau. J. Pharm. Pharmacol. 9, 381 (1957).
25. S. Irwin. Psychopharmacologia 13, 222 (1968).