Study of apo(a) length polymorphism and lipoprotein(a) concentrations in subjects with single or double apo(a) isoforms

Clinical Chemistry and Laboratory Medicine

Volumn 41, Issue 5, 2003, Pages 634-639

  Alaoui, Mariam ^a   Merle, Corinne ^a   Garnotel, Roselyne ^a   Jolly, Damien ^a   Durlach, Vincent ^a   Gillery, Philippe ^a  

^a SERVICE DE DERMATOLOGIE   (France)

Author keywords

Apolipoprotein(a); Cardiovascular risk; Lipoprotein(a)

Indexed keywords

APOLIPOPROTEIN A; ISOPROTEIN; LIPOPROTEIN A; RECOMBINANT PROTEIN;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CAUCASIAN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOBLOTTING; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MOLECULAR SIZE; MOLECULAR WEIGHT; NEPHELOMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN POLYMORPHISM; REGRESSION ANALYSIS; RISK ASSESSMENT; STATISTICAL DISTRIBUTION;

APOLIPOPROTEINS; APOPROTEIN(A); CARDIOVASCULAR DISEASES; FEMALE; HUMANS; IMMUNOBLOTTING; LIPOPROTEIN(A); MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROTEIN ISOFORMS;

EID: 0037665940     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.2003.096     Document Type: Article

References (41)

1. Berg K. Lp(a) lipoprotein: an overview. Chem Phys Lipids 1994; 67/68:9-16.
2. Scanu AM, Fless GM. Lipoprotein (a). Heterogeneity and biological relevance. J Clin Invest 1990; 85:1709-15.
3. Koschinsky ML, Marcovina SM, May LF, Gabel BR. Analysis of the mechanism of lipoprotein(a) assembly. Clin Genet 1997; 52:338-46.
4. Frank S, Durovic S, Kostner GM. The assembly of lipoprotein Lp(a). Eur J Clin Invest 1996; 26:109-14.
5. McLean JW, Tomlinson JE, Kuang WJ, Eaton DL, Chen EY, Fless GM, et al. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature 1987; 300:132-7.
6. Utermann G, Menzel HJ, Kraft HG, Duba HC, Kemmler HG, Seitz C. Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma. J Clin Invest 1987; 80:458-65.
7. Boerwinkle E, Leffert CC, Lin J, Lackner C, Chiesa G, Hobbs HH. Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J Clin Invest 1992; 90:52-60.
8. Magnaghi P, Cittero E, Malgaretti N, Acquati F, Ottolenghi S, Taramellei R. Molecular characterization of the human apo(a)-plasminogen gene family clustered on the telomeric region of the chromosome 6(6q26-27). Hum Mol Genet 1994; 3:437-42.
9. Garnotel R, Monnier F, Lefèvre F, Gillery P. Long-term variability of serum lipoprotein(a) concentrations in healthy fertile women. Clin Chem Lab Mad 1998; 36:317-21.
10. Seed M, Ayres KL, Humphries SE, Miller GJ. Lipoprotein(a) as a predictor of myocardial infarction in middle-aged men. Am J Med 2001; 110:22-7.
11. von Depka M, Nowak-Göttl U, Eisert R, Dieterich C, Barthels M, Scharrer I, et al. Increased lipoprotein(a) levels as an independent risk factor for venous thromboembolism. Blood 2000; 96:3364-8.
12. Djurovic S, Berg K. Epidemiology of Lp(a) lipoprotein: its role in atherosclerotic/thrombotic disease. Clin Genet 1997; 52:281-92.
13. Cremer P, Nagel D, Mann H, Labrot B, Muller-Berninger R, Elster H, Seidel D. Ten-year follow-up results from the Goettingen Risk, Incidence and Prevalence Study (Grips). Risk factors for myocardial infarction in a cohort of 5790 men. Atherosclerosis, 1997; 129:221-30.
14. Gaw A, Docherty G, Brown EA, Ford I. Predictors of plasma lipoprotein(a) concentration in the West of Scotland coronary prevention study cohort. Atherosclerosis 1999; 143: 445-50.
15. Lackner C, Boerwinkle E, Leffert CC, Rahming T, Hobbs HH. Molecular basis of apolipoprotein(a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis. J Clin Invest 1991; 87:2077-86.
16. Lackner C, Cohen JC, Hobbs HH. Molecular definition of the extreme size polymorphism in apolipoprotein(a). Hum Mol Genet 1993; 2:933-40.
17. Kraft HG, Lingenhel A, Kochl S, Hoppichler F, Kronenberg F, Abe A, et al. Apolipoprotein(a) kringle IV repeat number predicts risk for coronary heart disease. Arterioscler Thromb Vasc Biol 1996; 16:713-9.
18. Gazzaruso C, Garzaniti A, Buscaglia P, Bonetti G, Falcone C, Fratino P, et al. Association between apolipoprotein(a) phenotypes and coronary heart disease at young age. J Am Coll Cardiol 1999; 33:157-63.
19. Klausen IC, Sjøl A, Hansen PS, Gerdes LU, Møller L, Lemming L, et al. Apolipoprotein(a) isoforms and coronary heart disease in men. A nested case-control study. Atherosclerosis 1997; 132:77-84.
20. Kang C, Durlach V, Soulat T, Fournier C, Anglés-Cano E. Lipoprotein(a) isoforms display differences in affinity for plasminogen-like binding to human mononuclear cells. Arterioscler Thromb Vasc Biol 1997; 17:2036-43.
21. Gaubatz JW, Ghanem KI, Guevara J, Nava ML, Patsch W, Morrissett JD. Polymorphic forms of human apolipoprotein(a): inheritance and relationship of their molecular weights to plasma levels of lipoprotein(a). J Lipid Res 1990; 31:603-13.
22. Gaw A, Brown EA, Ford I. Impact of apo(a) length polymorphism and the control of plasma Lp(a) concentrations. Evidence for a threshold effect. Arterioscler Thromb Vasc Biol 1998; 18:1870-6.
23. Rosby O, Berg K. LPA gene: interaction between the apolipoprotein(a) size ('kringle IV' repeat) polymorphism and a pentanucleotide repeat polymorphism influences Lp(a) lipoprotein level. J Intern Med 2000; 247:139-52.
24. Kronenberg F, Trenkwalder E, Dieplinger H, Utermann G. Lipoprotein(a) in stored plasma samples and the ravages of time. Why epidemiological studies might fail. Arterioscler Thromb Vasc Biol 1996; 16:1568-72.
25. Gillery P, Arthuis P, Cuperlier C, Circaud R. Rate nephelometric assay of serum lipoprotein(a). Clin Chem 1993; 39:503-8.
26. Lippi G, Ruzzenente O, Brentegani C, Pierotti A, Guidi G. Evaluation of the analytical performances of a new fully automated commercial immunonephelometric assay for lipoprotein(a). Clin Chem Lab Med 1998; 36:719-23.
27. Hobbs GA, Kaplan IV, Levinson SS. Mechanized lipoprotein(a) assay as a marker for coronary artery disease illustrates the usefulness of high lipoprotein(a) levels. Clin Chim Acta 1998; 274:1-13.
28. Utermann G, Kraft HG, Menzel HJ, Hopferwieser T, Seitz C. Genetics of quantitative Lp(a) lipoprotein(a) trait. Relation of Lp(a) glycoprotein phenotypes to Lp(a) lipoprotein concentrations in plasma. Hum Genet 1988; 78:41-6.
29. Anglés-Cano E, Loyau S, Cardoso-Saldana G, Couderc R, Gillery P. A novel kringle-4 number-based recombinant apo(a) standard for human apo(a) phenotyping. J Lipid Res 1999; 40:354-9.
30. Berg K. A new serum type system in man-the Lp system. Acta Pathol Microbiol Immunol Scand 1963; 59:369-82.
31. Paultre F, Pearson TA, Weil HFC, Tuck CH, Myerson M, Rubin J, et al. High levels of Lp(a) with a small apo(a) isoform are associated with coronary artery disease in African American and white men. Arterioscler Thromb Vasc Biol 2000; 20:2619-24.
32. Paultre F, Tuck CH, Boden-Albala B, Kargman DE, Todd E, Jones J, et al. Relation of apo(a) size to carotid atherosclerosis in an elderly multiethnic population. Arterioscler Thromb Vasc Biol 2002; 22:141-6.
33. Martin S, Ladona MG, Pedro-Botet J, Covas MI, Rubres-Prat J. Differential expression of double-band apolipoprotein(a) phenotypes in healthy Spanish subjects detected by SDS-agarose immunoblotting. Clin Chim Acta 1998; 277:191-205.
34. Gaw A, Boerwinkle E, Cohen JC, Hobbs HH. Comparative analysis of the apo(a) gene, apo(a) glycoprotein and plasma concentrations of Lp(a) in three ethnic groups: evidence for no commun 'null' allele at the apo(a) locus. J Clin Invest 1994; 93:2526-34.
35. Kraft HG, Lingenhel A, Pang RW, Delport R, Trommsdorff M, Veermaak H, et al. Frequency distributions of apolipoprotein(a) kringle IV repeat alleles and their effects on lipoprotein(a) levels in Caucasian, Asian, and African populations: the distribution of null alleles is non-random. Eur J Hum Genet 1996; 4:74-87.
36. Marcovina SM, Albers JJ, Wijsman E, Zhan Z, Chapman NH, Kennedy H. Differences in Lp(a) concentrations and apo(a) polymorphism between black and white Americans. J Lipid Res 1996; 37:2569-85.
37. Kraft HG, Widergger M, Menzel HJ, Utermann G. Significant impact of the +93 C/T polymorphism in the apolipoprotein(a) gene on Lp(a) concentrations in Africans but not in Caucasians: confounding effect of linkage disequilibrium. Hum Mol Genet 1998; 7:257-64.
38. Wade DP, Puckey LH, Knight BL, Acquati F, Mihalich A, Taramelli R. Characterization of multiple enhancer regions upstream of the apoliprotein(a) gene. J Biol Chem 1997; 272:30387-99.
39. Rader DJ, Cain W, Ikewaki K, Talley G, Zech LA, Uscher D, Brewer Jr HB. The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate. J Clin Invest 1994; 93:2758-63.
40. Azrolan N, Gavish D, Breslow JL. Plasma lipoprotein(a) concentration is controlled by apolipoprotein(a) protein size and the abundance of hepatic apo(a) mRNA in a cynomolgus monkey model. J Biol Chem 1991; 266:13866-72.
41. Hobbs HH, White AL. Lipoprotein(a); intrigues and insights. Curr Opin Lipidol 1999; 10:225-36.