Anti-inflammatory activity of creatine supplementation in endothelial cells in vitro

British Journal of Pharmacology

Volumn 139, Issue 4, 2003, Pages 715-720

  Nomura, Akihiro ^a   Zhang, Minjie ^a   Sakamoto, Tohru ^a   Ishii, Yukio ^a   Morishima, Yuko ^a   Mochizuki, Mie ^a   Kimura, Toru ^a   Uchida, Yoshiyuki ^a   Sekizawa, Kiyohisa ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Adhesion; ATP; Creatine; E selectin; Endothelial cell; H 2O 2; ICAM 1; Permeability; Phosphocreatine; Serotonin

Indexed keywords

ADENOSINE A2A RECEPTOR AGONIST; CARRIER PROTEIN; CELL ADHESION MOLECULE; CREATINE; CREATINE PHOSPHATE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HYDROGEN PEROXIDE; INTERCELLULAR ADHESION MOLECULE 1;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ADHESION; CELL CULTURE; CELL MEMBRANE PERMEABILITY; ENDOTHELIUM CELL; ENERGY; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ALVEOLUS CELL; MUSCLE STRENGTH; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE; SUPPLEMENTATION;

ADENOSINE TRIPHOSPHATE; ANTI-INFLAMMATORY AGENTS; CELL ADHESION; CELLS, CULTURED; CREATINE; DIETARY SUPPLEMENTS; E-SELECTIN; ENDOTHELIUM, VASCULAR; GUANIDINES; HUMANS; HYDROGEN PEROXIDE; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; INTRACELLULAR MEMBRANES; LUNG; NEUTROPHIL ACTIVATION; NEUTROPHILS; PERMEABILITY; PHOSPHOCREATINE; PROPIONIC ACIDS; SEROTONIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037664612     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705316     Document Type: Article

References (34)

1. BALAZOVICH, K.J., SUCHARD, S.J., REMICK, D.G. & BOXER, L.A. (1996). Tumor necrosis factor-α and FMLP receptors are functionally linked during FMLP-stimulated activation of adherent human neutrophils. Blood, 88, 690-696.
2. BEUTLER, E. & BALUDA, M.C. (1964). Simplified determination of blood adenosine triphosphate using the firefly system. Blood, 23, 688-698.
3. BODIN, P. & BURNSTOCK, G. (1998). Increased release of ATP from endothelial cells during acute inflammation. Inflamm. Res., 47, 351-354.
4. BODIN, P. & BURNSTOCK, G. (2001). Evidence that release of adenosine triphosphate from endothelial cells during increased shear stress is vesicular. J. Cardiovasc. Pharmacol., 38, 900-908.
5. CHEN, X. & CHRISTOU, N.V. (1996). Relative contribution of endothelial cell and polymorphonuclear neutrophil activation in their interactions in systemic inflammatory response syndrome. Arch. Surg., 131, 1148-1154.
6. ENGLISH, D & ANDERSEN, B.R. (1974). Single-step separation of red blood cells, granulocytes and mononuclear leukocytes on discontinuous density gradients of ficoll-hypaque. J. Immunol. Methods, 5, 249-252.
7. 31P magnetic resonance spectroscopy study. Neurol. Res., 22, 145-150.
8. HASELTON, F.R., ALEXANDER, J.S. & MUELLER, S.N. (1993). Adenosine decreases permeability of in vitro endothelial monolayers. J. Appl. Physiol., 74, 1581-1590.
9. HASHIDA, R., ANAMIZU, C., YAGYU-MIZUNO, Y., OHKUMA, S. & TANAKA, T. (1986). Transcellular transport of fluorescein dextran through an arterial endothelial cell monolayer. Cell Struct. Funct., 11, 343-349.
10. ISHII, Y., KIMURA, T., MORISHIMA, Y., MOCHIZUKI, M., NOMURA, A., SAKAMOTO, T., UCHIDA, Y. & SEKIZAWA, K. (2002). S-carboxymethylcysteine inhibits neutrophil activation mediated by N-formyl-methionyl-leucyl-phenylalanine. Eur. J. Pharmacol., 449, 183-189.
11. KNIGHT, G.E., BODIN, P., DE GROAT, W.C. & BURNSTOCK, G. (2002). ATP is released from guinea pig ureter epithelium on distension. Am. J. Physiol., 282, F281-F288.
12. LOIKE, J.D., CAO, L., BRETT, J., OGAWA, S., SILBERSTEIN, S.C. & STERN, D. (1992). Hypoxia induced glucose transporter expression in endothelial cells. Am. J. Physiol., 263, C326-C333.
13. LOIKE, J.D., LOZLER, V.F. & SILVERSTEIN, S.C. (1979). Increased ATP and creatine phosphate turnover in phagocytosing mouse peritoneal macrophages. J. Biol. Chem., 254, 9558-9564.
14. LOWRY, O.H., ROSENBROUGH, N.J., FARR, A.L. & RANDALL, R.J. (1951). Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265-275.
15. MAZZINI, L., BALZARINI, C., COLOMBO, R., MORA, G., PASTORE, I., DE AMBROGIO, R. & CALIGARI, M. (2001). Effects of creatine supplementation on exercise performance and muscular strength in amyotrophic lateral sclerosis: preliminary results. J. Neurol. Sci., 191, 139-144.
16. MCPHERSON, J.A., BARRINGHAUS, K.G., BISHOP, G.G., SANDERS, J.M., RIEGER, J.M., HESSELBACHER, S.E., GIMPLE, L.W., POWERS, E.R., MACDONALD, T., SULLIVAN, G., LINDEN, J. & SAREMBOCK, I.J. (2001). Adenosine2A receptor stimulation reduces inflammation and neointimal growth in a murine carotid ligation model. Arterioscler. Thromb. Vasc. Biol., 21, 791-796.
17. MULLIGAN, M.S., VAPORCIYAN, A.A., MIYASAKA, M., TAMATANI, T. & WARD, P.A. (1993). Tumor necrosis factor-α regulates in vivo intrapulmonary expression of ICAM-1. Am. J. Pathol., 142, 1739-1749.
18. 2A adenosine receptor-mediated inhibition of renal injury and neutrophil adhesion. Am. J. Physiol., 279, F809-F818.
19. SCHEDEL, J.-M., TANAKA, H., KIYONAGA, A., SHINDO, M. & SCHUTZ, Y. (1999). Acute creatine ingestion in human: consequences on serum creatine and creatinine concentrations. Life Sci., 65, 2463-2470.
20. SERAYDARIAN, M.W. & ARTAZA, L. (1976). Regulation of energy metabolism by creatine in cardiac and skeletal muscle cells in culture. J. Mol. Cell. Cardiol., 8, 669-678.
21. SIMIONESCU, N. & PALADE, G.E. (1971). Dextran and glycogens as particulate tracers for studying capillary permeability. J. Cell Biol., 50, 616-624.
22. SIPILÄ, I., RAPOLA, J., SIMELL, O. & VANNAS, A. (1981). Supplementary creatine as a treatment for gyrate atrophy of the choroids and retina. N. Engl. J. Med., 304, 867-870.
23. SNOW, R.J., MCKENNA, M.J., SELIG, S.E., KEMP, J., STATHIS, C.G. & ZHAO, S. (1998). Effect of creatine supplementation on sprint exercise performance and muscle metabolism. J. Appl. Physiol., 84, 1667-1673.
24. SNOW, R.J. & MURPHY, R.M. (2001). Creatine and the creatine transporter: a review. Mol. Cell. Biochem., 224, 169-181.
25. STOUT, J.R., ECKERSON, J.M., MAY, E., COULTER, C. & BRADLEY-POPOVICH, E.J. (2001). Effects of resistance exercise and creatine supplementation on myasthenia gravis: a case study. Med. Sci. Sports Exerc., 33, 869-872.
26. STREHLER, B.L. & MCELROY, W.D. (1957). Assay of adenosine triphosphate. Methods Enzymol., 3, 871-873.
27. VANDENBERGHE, K., GORIS, M., VAN HECKE, P., VAN LEEMPUTTE, M., VANGERVEN, L. & HESPEL, P. (1997). Long-term CR intake is beneficial to muscle performance during resistance training. J. Appl. Physiol., 83, 2055-2063.
28. VANDENBERGHE, K., VAN HECKE, P., VAN LEEMPUTTE, M., VANGERVEN, F. & HESPEL, P. (1999). Phosphocreatine resynthesis is not affected by CR loading. Med. Sci. Sports Exerc., 31, 236-242.
29. VANNAS-SULONEN, K., SIPILÄ, I., VANNA, A., SIMELL, O. & RAPOLA, J. (1985). Gyrate atrophy of choroids and retina. A five-year follow-up of creatine supplementation. Ophthalmology, 92, 1719-1727.
30. VORGERD, M., GREHL, T., JAGER, M., MULLER, K., FREITAG, G., PATZOLD, T., BRUNS, N., FABIAN, K., TEGENTHOFF, M., MORTIER, W., LUTTMANN, A., ZANGE, J. & MALIN, J.P. (2000). Creatine therapy in myophosphorylase deficiency (McArdle disease): a placebo-controlled crossover trial. Arch. Neurol., 57, 956-963.
31. WILLIAMS, M.H. & BRANCH, J.D. (1998). CR supplementation and exercise performance: an update. J. Am. Coll. Nutr., 17, 216-234.
32. WINDISCHBAUER, A., GRIESMACHER, A. & MULLER, M.M. (1994). In vitro effects of hypoxia and reoxygenation on human umbilical endothelial cells. Eur. J. Clin. Chem. Clin. Biochem., 32, 279-284.
33. WYSS, M. & KADDURAH-DAOUK, R. (2000). Creatine and creatine metabolism. Physiol. Rev., 80, 1107-1213.
34. YASUHARA, M., FUJITA, S., ARIUE, K., KOHDA, K. & HAYASHI, C. (1982). A new enzymatic method to determine creatine. Clin. Chim. Acta, 112, 181-188.