Automated in Vitro Dermal Absorption (AIVDA): A New in Vitro Method for Investigating Transdermal Flux

ATLA Alternatives to Laboratory Animals

Volumn 25, Issue 3, 1997, Pages 347-357

  Moody, Richard P ^a  

^a HEALTH CANADA   (Canada)

Author keywords

AIVDA; Automated; DEET; Dermal absorption; HPLC; Human skin; Percutaneous

Indexed keywords

EID: 0037650016     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Moody, R P & Ritter, L. (1989) Dermal absorption of the pesticide lindane (1α, 2α, 3β, 4α, 5α, 6ß-hexachlorocyclohexane) in rats and rhesus monkeys effects of anatomical site Journal of Toxicology and Environmental Health 28, 161-169
2. Bronaugh, R L. & Maibach, H I (1991) In Vitro Percutaneous Absorption. Principles, Fundamentals, and Applications, 280 pp. Boca Raton, FL, USA: CRC Press
3. Howes, D , Guy, R., Hadgraft, J., Heylings, J , Hoeck, U., Kemper, F., Maibach, H , Marty, J-P., Merk, H., Parra, J., Rekkas, D , Rondelli, I, Schaefer, H , Tauber, U & Verbiese, N (1996). Methods for assessing percutaneous absorption. The report and recommendations of ECVAM workshop 13 ATLA 24, 81-206.
4. Moody, R P., Nadeau, B. & Chu, I (1995). In vitro dermal absorption of N,N-diethyl-m-toluamide (DEET) in rat, guinea-pig- and human skin In Vitro Toxicology 8, 263-275.
5. Gummer, C.L., Hinz, R.S & Maibach, H I (1997) The skin penetration cell, a design update. International Journal of Pharmaceutics 40, 101-104
6. Moody, R P. & Ritter, L (1992). An automated in vitro dermal absorption procedure II. Comparative in vivo and in vitro dermal absorption of the herbicide, fenoxaprop-ethyl (HOE 33171) in rats Toxicology in Vitro 6, 53-59
7. Moody, R.P. & Nadeau, B (1993) An automated in vitro dermal absorption procedure. III In vivo and in vitro comparison with the insect repellent DEET (N,N-diethyl-m-toluamide) in mouse, rat, guinea-pig, pig, human and tissue-cultured skin Toxicology in Vitro 7, 167-176.
8. Bronaugh, R L , Stewart, R F. & Simon, M (1986) Methods for in vitro percutaneous absorption studies VII Use of excised human skin. Journal of Pharmaceutical Science 75, 1094-1097
9. Collier, S W & Bronaugh, RL (1991). Receptor fluids In In Vitro Percutaneous Absorption: Principles, Fundamentals, and Applications (ed R L. Bronaugh & H I Maibach), pp. 31-49 Boca Raton, FL, USA: CRC Press
10. Bruno. T J & Svorones, P D N (1989). CRC Handbook of Basic Tables for Chemical Analysis, pp. 462-469 Boca Raton, FL, USA: CRC Press.
11. 14C-labelled N,N-diethyl-m-toluamide through human skin and effects of short-wave ultraviolet radiation on permeation. Toxicology in Vitro 4, 193-199
12. Gummer, C L & Maibach, H I. (1991) Diffusion cell design In In Vitro Percutaneous Absorption: Principles. Fundamentals, and Applications (ed R L. Bronaugh & H I Maibach), pp 7-16 Boca Raton. FL, USA: CRC Press