Enhanced Delivery of 5-Aminolevulinic Acid Esters by Iontophoresis in Vitro

Photochemistry and Photobiology

Volumn 77, Issue 3, 2003, Pages 304-308

  Lopez, Renata F V ^a,b,c   Bentley, M Vitória L B ^c   Delgado Charro, M Begoña ^a   Salomon, Denis ^a   Van Den Bergh, Hubert ^d,e   Lange, Norbert ^d,e   Guy, Richard H ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b Ctr Interuniv Rech d'Enseignement   (France)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d EPFL   (Switzerland)

^e UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOLEVULINIC ACID; AMINOLEVULINIC ACID ESTER; ESTER; MANNITOL; PRODRUG; PROTOPORPHYRIN; UNCLASSIFIED DRUG; DRUG DERIVATIVE;

ARTICLE; BIOAVAILABILITY; ELECTROOSMOSIS; IONTOPHORESIS; LIPOPHILICITY; PHOTODYNAMIC THERAPY; SKIN CANCER; SWINE; ANIMAL; BIOLOGY; IN VITRO STUDY; METABOLISM; PHOTOCHEMOTHERAPY; SKIN;

SUIDAE; SUS SCROFA;

AMINOLEVULINIC ACID; ANIMALS; IONTOPHORESIS; PHOTOBIOLOGY; PHOTOCHEMOTHERAPY; PRODRUGS; SKIN; SUS SCROFA;

EID: 0037639897     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/0031-8655(2003)077<0304:EDOAAE>2.0.CO;2     Document Type: Article

References (33)

1. Wolf, P., E. Rieger and H. Kerl (1993) Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid. J. Am. Acad. Dermatol. 28, 17-21.
2. Lui, H., S. Salasche, N. Kollias, T. Flotte, D. Mclean and R. R. Anderson (1995) Photodynamic therapy of nonmelanoma skin cancer with topical aminolevulinic acid; a clinical and histological study. Arch. Dermatol. 131, 737-738.
3. Kennedy, J. C. and R. H. Pottier (1992) Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy. J. Photochem. Photobiol. B: Biol. 14, 275-292.
4. Cairnduff, F., M. Stringer, E. Hudson, D. Ashand and S. Brown (1994) Superficial photodynamic therapy with topical 5-aminolevulinic acid for superficial primary and secondary skin cancer. Br. J. Cancer 69, 605-608.
5. Kennedy, J. C., R. H. Pottier and D. C. Pross (1990) Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J. Photochem. Photobiol. B: Biol. 6, 143-148.
6. Calzavara-Pinton, P., R. M. Szeimies and B. Ortel (2001) Photodynamic Therapy and Fluorescence Diagnosis in Dermatology. Elsevier, Amsterdam.
7. De Rosa, F. S. and M. V. L. B. Bentley (2000) Photodynamic therapy of skin cancers: sensitizers, clinical studies and future directives. Pharm. Res. 17, 1447-1455.
8. Fritsch, C., P. Lehmann, W. Stahl, K. W. Schulte, E. Blohm, K. Lang, H. Sies and T. Ruzicka (1999) Optimum porphyrin accumulation in epithelial skin tumours and psoriatic lesions after topical application of γ -aminolaevulinic acid. Br. J. Cancer 79, 1603-1608.
9. Wester, R. C. and H. I. Maibach (1989) In vivo animal models for percutaneous absorption. In Percutaneous Absorption (Edited by R. L. Bronaugh and H. I. Maibach), pp. 221-228. Marcel Dekker, New York.
10. Rhodes, L. A., M. M. Tsoukas, R. R. Anderson and N. Kollias (1997) Iontophoretic delivery of ALA provides a quantitative model for ALA pharmacokinetics and PpIX phototoxicity in human skin. J. Investig. Dermatol. 108, 87-91.
11. Lopez, R. F. V., M. V. L. B. Bentley, M. B. Delgado-Charro and R. H. Guy (2001) Iontophoretic delivery of 5-aminolevulinic acid (ALA): effect of pH. Pharm. Res. 18, 311-315.
12. Lange, N., P. Jichlinski, M. Zellweger, M. Forrer, A. Marti, L. Guillou, P. Kucera, G. Wagnières and H. van den Bergh (1999) Photodetection of early human bladder cancer based on the fluorescence of 5-aminolevulinic acid hexylester-induced protoporphyrin IX: a pilot study. Br. J. Cancer 80, 185-193.
13. Marti, A., N. Lange, H. van den Bergh, D. Sedmera, P. Jichlinski and K. Kucera (1999) Optimization of the formation and distribution of protoporphyrin IX in the urothelium: an in vitro approach. J. Urol. 162, 546-552.
14. Phipps, J. B., R. V. Padmanabhan and G. A. Lattin (1989) Iontophoretic delivery of model inorganic and drug ions. J. Pharm. Sci. 78, 365-369.
15. Marro, D., R. H. Guy and M. B. Delgado-Charro (2001) Characterization of the iontophoretic permselectivity properties of human and pig skin. J. Control. Release 70, 213-217.
16. Oishi, H., H. Nomiyama, K. Nomiyama and K. Tomokuni (1996) Fluorimetric HPLC determination of δ-aminolevulinic acid (ALA) in the plasma and urine of lead workers: biological indicators of lead exposure. J. Anal. Toxicol. 20, 106-110.
17. Glikfeld, P., C. Cullander, R. S. Hinz and R. H. Guy (1988) A new system for in vitro studies of iontophoresis. Pharm. Res. 5, 443-446.
18. Green, P. G., R. S. Hinz, C. Cullander, G. Yamane and R. H. Guy (1991) Iontophoretic delivery of amino acids and amino acid derivatives across the skin in vitro. Pharm. Res. 8, 1113-1120.
19. Boddé, H. E., P. E. H. Roemelé and W. M. Star (2002) Quantification of topically delivered 5-aminolevulinic acid by iontophoresis across ex vivo human stratum corneum. Photochem. Photobiol. 75, 418-423.
20. van den Akker, J. T., V. Iani, W. M. Star, H. J. Sterenborg and J. Moan (2000) Topical application of 5-aminolevulinic acid hexyl ester and 5-aminolevulinic acid to normal nude mouse skin: differences in protoporphyrin IX fluorescence kinetics and the role of the stratum comeum. Photochem. Photobiol. 75, 681-689.
21. Marro, D., Y. N. Kalia, M. B. Delgado-Charro and R. H. Guy (2001) Contributions of electromigration and electroosmosis to iontophoretic drug delivery. Pharm. Res. 10, 1701-1708.
22. Luzardo-Alvarez, A., M. B. Delgado-Charro and J. Blanco-Méndez (2001) Iontophoretic delivery of ropinirole hydrochloride: effect of current density and vehicle formulation. Pharm. Res. 18, 1714-1720.
23. Del Terzo, S., C. R. Behl and R. A. Nash (1989) Iontophoretic transport of a homologous series of ionized and nonionized model compounds: influence of hydrophobicity and mechanistic interpretation. Pharm. Res. 6, 85-90.
24. Guy, R. H., Y. N. Kalia, M. B. Delgado-Charro, V. Merino, A. López and D. Marro (2000) Iontophoresis: electrorepulsion and electroosmosis. J. Control. Release 64, 129-132.
25. Delgado-Charro, M. B. and R. H. Guy (1994) Characterization of convective solvent flow during iontophoresis. Pharm. Res. 11, 929-935.
26. Hoogstraate, A. J., V. Srinivasan, S. M. Simms and W. I. Higuchi (1994) Iontophoretic enhancement of peptides: behavior of leuprolide versus model permeants. J. Control. Release 31, 41-47.
27. Hirvonen, J. and R. H. Guy (1997) Iontophoretic delivery across the skin: electroosmosis and its modulation by drug substances. Pharm. Res. 14, 1258-1263.
28. Burnette, R. R. and B. Ongpipattanakul (1987) Characterization on the permselective properties of excised human skin during iontophoresis. J. Pharm. Sci. 76, 765-773.
29. Marro, D., Y. N. Kalia, M. B. Delgado-Charro and R. H. Guy (2001) Optimizing iontophoretic drug delivery: identification and distribution of the charge-carrying species. Pharm. Res. 10, 1709-1713.
30. Gerscher, S., J. P. Connelly, J. Griffiths, S. B. Brown, A. J. MacRobert, G. Wong and L. E. Rhodes (2000) Comparison of the pharmacokinetics and phototoxicity of protoporphyrin IX metabolized from 5-aminolevulinic acid and two derivatives in human skin in vivo. Photochem. Photobiol. 75, 569-574.
31. Green, P., B. Shroot, F. Bernerd, W. R. Pilgrim and R. H. Guy (1992) In vitro and in vivo iontophoresis of a tripeptide across nude rat skin. J. Control. Release 20, 209-218.
32. van der Geest, R., T. van Laar, J. M. Gubbens-Stibbe, H. E. Boddé and M. Danhof (1997) Iontophoretic delivery of apomorphine II: an in vivo study in patients with Parkinson's disease. Pharm. Res. 14, 1804-1810.
33. Guy, R. H., M. B. Delgado-Charro and Y. N. Kalia (2001) Iontophoretic transport across the skin. Skin Pharmacol. Appl. Skin Physiol. 14(Suppl. 1), 35-40.