Bile salt/lecithin mixed micelles optimized for the solubilization of a poorly soluble steroid molecule using statistical experimental design

Drug Development and Industrial Pharmacy

Volumn 29, Issue 4, 2003, Pages 441-450

  Magee, Gavin A ^a   French, Jane ^a   Gibbon, Bob ^a   Luscombe, Chris ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Bile salts; Enhanced solubility; Experimental design; Lecithin surfactant; Mixed micelles; Oral delivery; Parenteral delivery

Indexed keywords

BILE SALT; CHOLIC ACID; DRUG VEHICLE; FLUTICASONE PROPIONATE; GLYCOCHOLIC ACID; PHOSPHATIDYLCHOLINE; STEROID; SURFACTANT; TAUROCHOLIC ACID; WATER;

ARTICLE; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG MIXTURE; DRUG SOLUBILITY; EXPERIMENTAL DESIGN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LINEAR REGRESSION ANALYSIS; LIPOPHILICITY; MICELLE; PARENTERAL DRUG ADMINISTRATION; PHYSICAL CHEMISTRY; SOLUBILIZATION; TURBIDITY; VISCOSITY;

BILE ACIDS AND SALTS; CHEMISTRY, PHYSICAL; MODELS, STATISTICAL; PHOSPHATIDYLCHOLINES;

EID: 0037627422     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120018379     Document Type: Article

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