Pharmacokinetics and safety of valaciclovir in children with Epstein-Barr virus illness

Drugs in R and D

Volumn 3, Issue 6, 2002, Pages 365-373

  Simon, Michael W ^a   Fish, Douglas N ^b   Deeter, Robert G ^c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; VALACICLOVIR;

ADOLESCENT; ADULT; AREA UNDER THE CURVE; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; EPSTEIN BARR VIRUS; FEMALE; GASTROINTESTINAL SYMPTOM; HEADACHE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; TABLET; VIRUS INFECTION;

EID: 0037626794     PISSN: 11745886     EISSN: None     Source Type: Journal    
DOI: 10.2165/00126839-200203060-00001     Document Type: Article

References (34)

1. Simon MW. Apnea of infancy associated with Epstein-Barr virus infection. J Ky Med Assoc 1993; 91: 401-2
2. Simon MW. Apnea associated with Epstein-Barr virus infection [letter]. Pediatr Infect Dis 1994; 13: 82
3. Pereira MS, Blake JM, McCrae AD. EB virus antibody at different ages. Br Med J 1969; 4: 526-7
4. Simon MW. Intrafamilial spread of Epstein-Barr virus. J Ky Med Assoc 1995; 93: 453-5
5. Simon MW. Epstein-Barr virus infection in infants and their mothers. Am Fam Physician 1997; 56: 380-1
6. Lang DJ. Infectious mononucleosis (Epstein-Barr virus). In: Feigin RD, Cherry JR, editors. Textbook of pediatric infectious diseases. Philadelphia (PA). WB Saunders Co., 1981
7. Davis HW. Pediatric infectious disease. In: Zitelli BJ, Davis HW, editors. Atlas of pediatric physical diagnosis. St Louis (MO): The CV Mosby Co, 1987
8. Sutton RNP, Marston DS, Almond EJP, et al. Aspects of Epstein-Barr virus infection in children. Arch Dis Child 1974; 49: 102-6
9. Fleisher G, Henle W, Henle G, et al. Primary infection with Epstein-Barr virus in infants in the United States: clinical and serologic observations. J Infect Dis 1979; 139: 553-8
10. Joncas J, Boucher J, Granger-Julien M, et al. Epstein-Barr virus infection in the neonatal period and in childhood. Can Med Assoc J 1974; 110: 33-7
11. Sumaya CV. Primary Epstein-Barr virus infections in children. Pediatrics 1977; 59: 15-21
12. Simon MW. Manifestations of relapsing Epstein-Barr virus illness. J Ky Med Assoc 1997; 95: 240-3
13. Beutner KR. Valacyclovir: a review of its antiviral activity, pharmacokinetic properties, and clinical efficacy. Antiviral Res 1995; 28: 281-90
14. Collins P. The spectrum of antiviral activities of acyclovir in vitro and in vivo. J Antimicrob Chemother 1983; 12: 19-27
15. Weller S, Blum R, Doucette M, et al. Pharmacokinetics of 256U87 (an acyclovir pro-drug) after escalating single- and multiple-dose administration to normal volunteers. Clin Pharmacol Ther 1993; 54: 595-605
16. Wang LH, Schultz M, Weller S, et al. Pharmacokinetics and safety of multiple-dose valacyclovir in geriatric volunteers with and without concomitant diuretic therapy. Antimicrob Agents Chemother 1996; 40: 80-5
17. Blum MR, Soul-Lawton J, Smith CM, et al. Increased bioavailability of acyclovir from oral valacyclovir in healthy volunteers [abstract]. Antiviral Res 1993; 23 Suppl 1: 74-78
18. Jacobson MA, Gallant J, Wang LH, et al. Phase I trial of valacyclovir, the I-valyl ester of acyclovir, in patients with advanced human immunodeficiency virus disease. Antimicrob Agents Chemother 1994; 38: 1534-40
19. Andersson J, Britton S, Ernberg I, et al. Effect of acyclovir on infectious mononucleosis: a double-blind, placebo-controlled study. J Infect Dis 1986; 153: 283-90
20. Straus ES, Armstrong G, Preble O, et al. Acyclovir (ACV) treatment of chronic fatigue syndrome with unusual EBV serologic profiles: lack of efficacy in a controlled trial [abstract]. Clin Res 1987; 35: 618A
21. Beunter KR, Friedman DJ, Forszpaniak C, et al. Valacyclovir compared with acyclovir for improved therapy for herpes zoster in immunocompetent adults. Antimicrobial Agents Chemother 1995; 39: 1546-53
22. Simon MW. Correlation between clinical, physical, and laboratory features in children with EBV illness. J Ky Med Assoc 1993; 91: 504-8
23. Pagano JS, Sixbey JW, Lin J-C. Acyclovir and Epstein-Barr virus infection. J Antimicrobial Chemother 1983; 12 Suppl B: 113-21
24. Andersson J, Ernberg I. Management of Epstein-Barr virus infections. Am J Med 1988; 85 Suppl 2A: 107-15
25. Van der Horst C, Joncas J, Ahronheim G, et al. Lack of effect of peroral acyclovir for the treatment of acute infectious mononucleosis. J Infect Dis 1991; 164: 788-92
26. Andersoon J, Skoldenberg B, Henle W, et al. Acyclovir treatment in infectious mononucleosis: a clinical and virological study. Infection 1987; 15 Suppl. 1: 14-20
27. Tynell E, Aurelius E, Brandell A, et al. Acyclovir and prednisolone treatment of acute infectious mononucleosis: a multicenter, double-blind, placebo-controlled study. J Infect Dis 1996; 174: 324-31
28. Torre D, Tambini R. Acyclovir for treatment of infectious mononucleosis: a meta-analysis. Scand J Infect Dis 1999; 31: 543-7
29. Dodd DA, Burger J, Edwards KM, et al. Varicella in a pediatric heart transplant population on nonsteroid maintenance immunosuppression. Pediatrics 2001; 108: e80
30. Joncas JJ, Chicoine L, Thivierge R, et al. Epstein-Barr virus antibodies in the cerebrospinal fluid: a case of infectious mononucleosis with encephalitis. Am J Dis Child 1974; 127: 282-5
31. Rickinson AB. Cellular immunological responses to the virus infection. In: Epstein MA, Achong BG, editors. The Epstein-Barr virus: recent advances. New York (NY): John Wiley and Sons, 1986
32. Bender CE. The value of corticosteroids in the treatment of infectious mononucleosis. JAMA 1967; 199: 529-31
33. Collins M, Fleisher G, Kreisberg J, et al. Role of steroids in the treatment of infectious mononucleosis in the ambulatory college student. J Am Coll Health 1984; 33: 101-5
34. Brandfonbrener A, Epstein A, Wu S, et al. Corticosteroid therapy in Epstein-Barr virus infection. Effect of lymphocyte class, subset and response to early antigen. Arch Intern Med 1986; 146: 337-9