Induction and repair of DNA strand breaks in bovine lens epithelial cells after high LET irradiation

Advances in Space Research

Volumn 31, Issue 6, 2003, Pages 1583-1591

  Baumstark Khan, C ^a   Heilmann, J ^b   Rink, H ^c  

^a GERMAN AEROSPACE CENTER DLR   (Germany)

^b GSI HELMHOLTZZENTRUM FÜR SCHWERIONENFORSCHUNG GMBH   (Germany)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; HYDROXYAPATITE; IRRADIATION; MUTAGENESIS; X RAYS;

CATARACTS;

DNA;

RADIATION EXPOSURE;

EID: 0037623767     PISSN: 02731177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0273-1177(03)00095-4     Document Type: Article

References (24)

1. Andley, U. P., J. S. Rhim, L. T. Chylack Jr., and T. P. Fleming, Propagation and immortalization of human lens epithelial cells in culture. Invest. Ophthalmol. Visual Sci. 35, 3094-3102, 1994
2. Aufderheide, E.; H. Rink, L. Hieber, and G. Kraft, Heavy ion effects on cellular DNA: strand break induction and repair in cultured diploid lens epithelial cells. Int. J. Radiat. Biol. 51, 779-790, 1987
3. Baumstark-Khan C., A calculation method of PLD recovery based on saturation kinetics. in Frontiers in Radiation Biology, eds. E. Riklis, pp. 513-520, VCH & Balaban Publishers, Weinheim New York Rehovot, 1990
4. Baumstark-Khan C., J. Schneider, and H. Rink, Radiation sensitivity of cultured bovine lens epithelial cells. Ophthalmic Res. 23,:235-239, 1991
5. Baumstark-Khan, C., E. Aufderheide, and H. Rink, X-ray induced DNA strand break induction and rejoining in cultured bovine lens epithelial cells, Ophthalmic Res. 24, 220-227, 1992
6. Bergeder, H.-D., H. Rink, and O. Hockwin, Die Röntgenkatarakt. Ein Modell zur Untersuchung der Katakaktogenese. Klinische Monatsblätter der Augenheilkunde 180, 13-16, 1982
7. Blöcher, D., and W. Pohlit, DNA double strand breaks in Ehrlich ascites tumour cells at low doses of x-rays. II. Can cell death be attributed to double strand breaks? Int. J. Radiat. Biol. 42, 329-338, 1982
8. Brenner D. J., C. Medvedovsky, Y. Huang, G. R. Merriam, and B. V., Worgul, Accelerated heavy particles and the lens. VI. RBE studies at low doses. Radiat. Res. 128, 73-81, 1991
9. Brenner D. J., C. Medvedovsky, Y. Huang, and B. V., Worgul, Accelerated heavy particles and the lens. VIII. Comparison between the effects of acute low doses of iron ions (190 keV/microns) and argon ions (88 keV/microns).. Radiat. Res. 133, 198-203, 1993
10. Cucinotta F. A., F. K. Manuel, J. Jones, G. Iszard, J. Murrey, B. Djojonegro, and M. Wear, Space radiation and cataracts in astronauts. Radiat. Res., 156, 460-466, 2001
11. Fleischer R. L., P. B. Price, and R. M. Walker, Nuclear tracks in solids. UC Press, California, USA, (1975)
12. Frankenberg-Schwager, M., D. Frankenberg, D. Blöcher, and C. Adamczyk,, Repair of DNA double-strand breaks in irradiated yeast cells under nongrowth conditions. Radiat. Res. 82, 498-510, 1980
13. Geard C. R., and B. V. Worgul, The lens and cataract: Clastogenic responses in epithelial cells of the organ-cultured rat lens. Environ. Mutagen. 9, 111-122, 1987
14. Heilmann, J., H. Rink, G. Taucher-Scholz, and G. Kraft, DNA strand break induction and rejoining and cellular recovery in mammalian cells after heavy-ion irradiation. Radiat. Res. 135, 46-55, 1993
15. Ibaraki N., S. C. Chen, L. R. Lin, H. Okamoto, J. M. Pipas, and V. N. Reddy, Human lens epithelial cell line. Exp. Eye Res. 67, 577-585, 1998
16. Jose, J. G., The role of DNA damage, its repair and its misrepair in the ethiology of senile cataract. Ophthalmic Res. 10, 52-62, 1978
17. Kampf, G, Die Erzeugung von DNS Strangbrüchen durch ionisierende Strahlen unterschiedlicher Qualität und ihre Bedeutung für die Zellinaktivierung. Techn. Rep., Zentralinstitut für Kernforschung Rossendorf, KfR 504, 1983
18. Kellerer, A. M, Microdosimetric concepts relevant to HZE-particles. In: Proceedings of the European Symposium on Life Sciences in Space Research, pp. 271-277, European Space Agency (ESA), Paris, (1977)
19. Koch, H.-R., and O. Hockwin, Radiation cataractogenesis, in: Radiant Energy and the Eye. eds.: S. Lerman, pp 286-302, MacMillan, New York, USA, 1980
20. Medvedovsky C., B. V., Worgul, Y. Huang, D. J. Brenner, F. Tao, J. Miller, C. Zeitlin, and E. J. Ainswort, The influence of dose, dose rate and particle fragmentation on cataract induction by energetic iron ions. Adv. Space Res. 14, 475-482, 1994
21. Rink H., R. Zblewski, and C. Baumstark-Khan C, Repair capacity and aging of lens epithelial cells in vitro, in: Modern Trends in Ageing Research, eds. Y. Courtois, B. Faucheux, B. Forette, D.L. Knook, J.A. Tréton, pp. 303-309, INSERM, Paris, Vol. 147, 1986
22. Ritter, M. A., J. E., Cleaver, and C.A. Tobias, High-LET radiations induce a large proportion of non-rejoining DNA breaks. Nature 266, 653-655, (1977)
23. Worgul B. V., Cataract analysis and the assessment of radiation risk in space. Adv. Space Res. 6, 285-293, 1986
24. Wulf, H., W. Kraft-Weyrather, H. G., Miltenburger, E. A., Blakely, C. A. Tobias, and G. Kraft, Heavy-ion effects on mammalian cells: inactivation measurements with different cell lines. Radiat. Res. Suppl. 8, S122-S134, 1985