Differential accumulation of non-transferrin-bound iron by cardiac myocytes and fibroblasts

Journal of Molecular and Cellular Cardiology

Volumn 35, Issue 5, 2003, Pages 505-514

  Liu, Ying ^a   Parkes, Joel G ^a   Templeton, Douglas M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cardiac cells; Cardiac fibroblasts; Iron overload; Iron transport; Non transferrin bound iron

Indexed keywords

BETA ACTIN; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; TRANSFERRIN FE 59;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CELL CULTURE; CELL TYPE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FIBROBLAST; HEART MUSCLE CELL; HISTOLOGY; IRON KINETICS; IRON TRANSPORT; MICHAELIS CONSTANT; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RAT;

EID: 0037623420     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2828(03)00072-5     Document Type: Article

References (43)

1. Adams P.C. Templeton D.M. Molecular and cellular iron transport. 2002;699-724 Marcel Dekker, New York.
2. Olivieri N.F. The beta-thalassemias. N Engl J M. 341:1999;99-109.
3. Olivieri N.F., Brittenham G.M. Iron-chelating therapy and the treatment of thalassemia. Blood. 89:1997;739-761.
4. Andrews N.C. Medical progress: disorders of iron metabolism. N Engl J M. 341:1999;1986-1995.
5. Short E.M., Winkle R.A., Billingham M.E. Myocardial involvement in idiopathic hemochromatosis. Morphologic and clinical improvement following venisection. Am J M. 70:1981;1275-1279.
6. Lombardo T., Tamburino C., Bartoloni G., Morrone M.L., Frontini V., Italia F., et al. Cardiac iron overload in thalassemic patients: an endomyocardial biopsy study. Ann Hematol. 71:1995;135-141.
7. Engle M.A., Erlandson M., Smith C.H. Late cardiac complications of chronic, severe, refractoryanemia with hemochromatosis. Circulation. 30:1964;698-705.
8. Gabbiani G. The biology of the myofibroblast. Kidney Int. 41:1992;530-532.
9. Johnson R.J. The glomerular response to injury: progression or resolution? Kidney Int. 45:1994;1769-1782.
10. Gressner A.M. Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis. Kidney Int. 49:1996;S39-45.
11. Phan S.H., Zhang K., Zhang H.Y., Gharaee-Karmani M. The myofibroblast as an inflammatory cell in pulmonary fibrosis. Curr Topic Pathol. 93:1998;173-182.
12. Zak R. Cell proliferation during cardiac growth. Am J Cardiol. 31:1973;211-219.
13. Nag A.C. Study of non-muscle cells in the adult mammalian heart: a fine structural analysis and distribution. Cytobios. 28:1980;41-61.
14. Sigel A.V., Centrella M., Eghbali-Webb M. Regulation of proliferative response of cardiac fibroblasts by transforming growth factor-β1. J Mol Cell Cardiol. 28:1996;1921-1929.
15. Long C.S., Henrich C.J., Simpson P.C. A growth factor for cardiac myocytes is produced by cardiac nonmyocytes. Cell Reg. 2:1991;1081-1095.
16. 1 and phorbol myristate acetate on cardiac fibroblasts. Regulation of fibrillar collagen mRNAs and expression of early transcription factors. Circ Res. 69:1991;483-490.
17. Buja L., Roberts W. Iron in the heart: etiology and clinical significance. Am J M. 51:1971;209-221.
18. Fitchett D.H., Coltart D.J., Littler W.A., Leyland M.J., Trueman T., Gozzard D.I., et al. Cardiac involvement in secondary haemochromatosis: a catheter biopsy study and analysis of myocardium. Cardiovasc Res. 14:1980;719-724.
19. Arnett E.N., Nienhuis A.W., Henry W.L., Ferrans V.J., Redwood D.R., Roberts W.C. Massive myocardial hemosiderosis: a structure-function conference at the National Heart and Lung Institute. Am Heart J. 90:1975;777-787.
20. Parkes J.G., Liu Y., Sirna J.B., Templeton D.M. Changes in gene expression with iron loading and chelation in cardiac myocytes and non-myocytic fibroblasts. J Mol Cell Cardiol. 32:2000;233-246.
21. Liu Y., Templeton D.M. The effects of cardiac myocytes on interstitial fibroblasts in toxic iron overload. Cardiovasc Toxicol. 1:2001;299-308.
22. Parkes J.G., Hussain R.A., Olivieri N.F., Templeton D.M. Effects of iron loading on uptake, speciation and chelation of iron in cultured myocardial cells. J Lab Clin M. 122:1993;36-47.
23. McManus J.F.A., Mowry R.W. Staining methods. histological and histochemical. 1960;195-197 Paul B. Hober, Inc, New York.
24. Stuhne-Sekalec L., Xu S.X., Parkes J.G., Olivieri N.F., Templeton D.M. Speciation of tissue and cellular iron with on-line detection by inductively coupled plasma-mass spectrometry. Anal Biochem. 205:1992;278-284.
25. Randell E.W., Parkes J.G., Olivieri N.F., Templeton D.M. Uptake of non-transferrin-bound iron by both reductive and nonreductive processes is modulated by intracellular iron. J Biol Chem. 269:1994;16046-16053.
26. 3+ transport by iron-loaded cardiac myocytes. Toxicology. 117:1997;141-151.
27. May J.M., Qu Z.C., Mendiratta S. Role of ascorbic acid in transferrin-independent reduction and uptake of iron by U-937 cells. Biochem Pharmacol. 57:1999;1275-1282.
28. Parkes J.G., Randell E.W., Olivieri N.F., Templeton D.M. Modulation by iron loading and chelation of the uptake of non-transferrin-bound iron by human liver cells. Biochim Biophys Acta. 1243:1995;373-380.
29. Kaplan J., Jordan I., Sturrock A. Regulation of the transferrin-independent iron transport system in cultured cells. J Biol Chem. 266:1991;2997-3004.
30. Inman R.S., Wessling-Resnick M. Characterization of transferrin-independent iron transport in K562 cells. Unique properties provide evidence for multiple pathways of iron uptake. J Biol Chem. 268:1993;8521-8528.
31. m transporter for non-transferrin-bound iron in isolated rat hepatocytes. Am J Physiol. 269:1995;G570-576.
32. Bali P.K., Harris W.R. Site-specific rat constants for iron removal from diferric transferrin by nitrilotris (methylenephosphonic acid) and pyrophosphate. Arch Biochem Biophys. 281:1990;251-256.
33. Horobin R.W., Bancroft J.D. Troubleshooting histologystains. 1998;Churchill Livingstone, New York.
34. Preisig P. What makes cells grow larger and how do they do it? Renal hypertrophy revisited. Exp Nephrol. 7:1999;273-283.
35. Féliers D., Frank M.A., Riley D.J. Activation of cyclin D1-cdk4 and cdk4-directed phosphorylation of RB protein in diabetic mesangial hypertrophy. Diabetes. 51:2002;3290-3299.
36. Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., Boron W.F., et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 388:1997;482-488.
37. Iancu T.C., Shiloh H., Link G., Bauminger E.R., Pinson A., Hershko C. Ultrastructural pathology of iron-loaded rat myocardial cells in culture. Br J Exp Path. 68:1987;53-65.
38. Schneider W. Iron hydrolysis and the biochemistry of iron - the interplay of hydroxide and biogenic ligands. Chimia. 42:1988;9-20.
39. Thulborn K.R., Sorensen A.G., Kowall N.W., McKee A., Lai A., McKinstry R.C., et al. The role of ferritin and hemosiderin in the MR appearance of cerebral hemorrhage: a histopathologic biochemical study in rats. Am J Roentgenol. 154:1990;1053-1059.
40. Bizzi A., Hill J.M., Brooks R.A., Di Chiro G. Is Perls stain specific for hemosiderin? Am J Neuroradiol. 12:1991;805. [Letter].
41. Hanson E.S., Leibold E. Templeton D.M. Molecular and cellular iron transport. 2002;201-235 Marcel Dekker, New York.
42. Gunshin H., Hediger M.A. Templeton D.M. Molecular and cellular iron transport. 2002;155-173 Marcel Dekker, New York.
43. Tchernitchko D., Bourgeois M., Martin M.E., Beaumont C. Expression of the two mRNA isoforms of the iron transporter Nramp2/DMTI in mice and function of the iron responsive element. Biochem J. 363:2002;449-455.