Reduction of viral myocarditis in mice lacking perforin

Research Communications in Molecular Pathology and Pharmacology

Volumn 110, Issue 3-4, 2001, Pages 229-237

  Koike, Hiroto ^a,b   Kanda, Tsugiyasu ^a   Sumino, Hiroyuki ^a   Yokoyama, Tomoyuki ^a   Arai, Masashi ^a   Motooka, Masahiko ^a   Suzuki, Tadashi ^a   Tamura, Jun'ichi ^a   Kobayashi, Isao ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Apotosis; Cytotoxic T lymphocytes; Lymphocytotoxicity; Mice lacking perforin; Myocardial apotosis; Myocardial necrosis; Perforin; Perforin knockout; Viral myocarditis; Viral titer

Indexed keywords

PERFORIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CARDIOMYOPATHY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; DISEASE SEVERITY; ENCEPHALOMYOCARDITIS VIRUS; FEMALE; GENE EXPRESSION; HEART MUSCLE INJURY; HEART MUSCLE NECROSIS; KNOCKOUT MOUSE; LYMPHOCYTIC INFILTRATION; LYMPHOCYTOTOXICITY; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS MYOCARDITIS; WILD TYPE;

ANIMALS; APOPTOSIS; BODY WEIGHT; ENCEPHALOMYOCARDITIS VIRUS; FEMALE; IN SITU NICK-END LABELING; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MYOCARDITIS; ORGAN SIZE; PORE FORMING CYTOTOXIC PROTEINS;

EID: 0037623371     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Binah O. (2000) Immune effector mechanisms in myocardial pathologies. Int J Mol Med. 6:3-16
2. Kanda T, Nagaoka H, Kaneko K, Wilson JE, McManus BM, Imai S, Suzuki T, Murata K, Kobayashi I. (1995) Synergistic effects of tacrolimus and human interferon-alpha A/D in murine viral myocarditis. J Pharmacol Exp Ther. 274:487-493.
3. Kanda T, Yokoyama T, Imai S, Suzuki T, Murata K, Kobayashi I. (1995) Effect of combination therapy with OK432 and recombinant human interferon-alpha A/D on atrial natriuretic peptide gene expression in mice with viral myocarditis. J Pharmacol Exp Ther. 274:494-498.
4. Kanda T, Koike H, Arai M, Wilson JE, Carthy CM, Yang D, McManus BM, Nagai R, Kobayashi I. (1999) Increased severity of viral myocarditis in mice lacking lymphocyte maturation. Int J Cardiol. 68:13-22.
5. Kanda T, McManus JE, Nagai R, Imai S, Suzuki T, Yang D, McManus BM, Kobayashi I. (1996) Modification of viral myocarditis in mice by interleukin-6. Circ Res. 78:848-56.
6. Kishimoto C, Kuribayashi K, Masuda T, Tomioka N, Kawai C. (1985) Immunologic behavior of lymphocytes in experimental viral myocarditis: significance of T lymphocytes in the severity of myocarditis and silent myocarditis in BALB/c-nu/nu mice. Circulation. 71:1247-1254.
7. Kishimoto C, Kuribayashi K, Fukuma K, Masuda T, Tomioka N, Abelmann WH, Kawai C. (1987) Immunologic identification of lymphocyte subsets in experimental murine myocarditis with encephalomyocarditis virus. Different kinetics of lymphocyte subsets between the heart and the peripheral blood, and significance of Thy 1.2+ (pan T) and Lyt 1+, 23+ (immature T) subsets in the development of myocarditis. Circ Res. 61:715-725.
8. Mason JW, O'Connell JB, Herskowitz A, Rose NR, McManus BM, Billingham ME, Moon TE. (1995) A clinical trial of immunosuppressive therapy for myocarditis: The Myocarditis Treatment Trial Investigators. N Engl J Med. 333:269-275.
9. Matsumori A, Kawai C. (1982) An animal model of congestive (dilated) cardiomyopathy: dilatation and hypertrophy of the heart in the chronic stage in DBA/2 mice with myocaditis caused by encephalomyocarditis virus. Circulation. 66:355-360.
10. Seko Y, Shinkai Y, Kawasaki A, Yagita H, Okumura K, Yazaki Y. (1993) Evidence of perforin-mediated cardiac myocyte injury in acute murine myocarditis caused by Coxsackie virus B3. J Pathol. 170:53-58.
11. Rezkalla S, Khatib G, Khatib R. (1986) Coxsackievirus B3 murine myocarditis: deleterious effects of nonsteroidal anti-inflammatory agents. J Lab Clin Med. 107:393-395.
12. Podack, ER, hengartner H, Lichtenheld, MG. (1991). Annu Rev Immunol. 9, 129-157.
13. von Herrath M, Coon B, Homann D, Wolfe T, Guidotti LG. (1999) Thymic tolerance to only one viral protein reduces lymphocytic choriomeningitis virus-induced immunopathology and increases survival in perforin-deficient mice. J Virol. 73:5918-5925.
14. Walsh CG, Matloubian M, Liu CC. (1994) Immune function in mice lacking the perforin gene. Proc Natl Acad Sci, USA. 91;10854-10858.
15. Yokoyama T, Kanda T, Suzuki T, Murata K. (1992) Effects of lobenzarit on murine acute viral myocarditis. Cardiovasc Drugs Ther. 6:403-7.