Intravenous immunoglobulin treatment in women with recurrent abortions: Increased cytokine levels and reduced Th1/Th2 lymphocyte ratio in peripheral blood

American Journal of Reproductive Immunology

Volumn 49, Issue 2, 2003, Pages 84-89

  Yamada, Hideto ^a   Morikawa, Mamoru ^a   Furuta, Itsuko ^a   Kato, Emi H ^a   Shimada, Shigeki ^a   Iwabuchi, Kazuya ^b   Minakami, Hisanori ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Immunoglobulin; Pregnancy; Recurrent spontaneous abortion; Th1 Th2 cytokine

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GESTATIONAL AGE; HUMAN; HUMAN CELL; IDIOPATHIC DISEASE; IMMUNOREGULATION; LYMPHOCYTE COUNT; METABOLIC BALANCE; PREGNANCY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RECURRENT ABORTION; TH1 CELL; TH2 CELL;

ABORTION, HABITUAL; ANIMALS; CYTOKINES; FEMALE; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; IMMUNOTHERAPY; MICE; TH1 CELLS; TH2 CELLS;

EID: 0037613663     PISSN: 87558920     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0897.2003.01184.x     Document Type: Article

References (40)

1. The German RSA/IVIG Group: Intravenous immunoglobulin in the prevention of recurrent miscarriage. Br J Obstet Gynaecol 1994; 101:1072-1077.
2. Christiansen OB, Mathiesen O, Husth M, Rasmussen KL, Ingerslev HJ, Lauritsen JG, Grunnet N: Placebo-controlled trial of treatment of unexplained secondary recurrent spontaneous abortions and recurrent late spontaneous abortions with i.v. Immunoglobulin Hum Reprod 1995; 10:2690-2695.
3. Stephenson MD, Dreher K, Houlihan E, Wu V: Prevention of unexplained recurrent spontaneous abortion using intravenous immunoglobulin: A prospective, randomized, double-blinded, placebo-controlled trial. Am J Reprod Immunol 1998; 39:82-88.
4. Perino A, Vassiliadis A, Vucetich A, Colacurci N, Menato G, Cignitti M, Semprini AE: Short-term therapy for recurrent abortion using intravenous immunoglobulins: Results of a double-blind placebo-controlled Italian study. Hum Reprod 1997; 12:2388-2392.
5. Jablonowska B, Selbing A, Palfi M, Ernerudh J, Kjellberg S, Lindton B: Prevention of recurrent spontaneous abortion by intravenous immunoglobulin: A double-blind placebo-controlled study. Hum Reprod 1999; 14:838-841.
6. Coulam CB, Krysa L, Stern JJ, Bustillo M: Intravenous immunoglobulin for treatment of recurrent pregnancy loss. Am J Reprod Immunol 1995; 34:333-337.
7. Yamada H, Kishida T, Kobayashi N, Kato EH, Hoshi N, Fujimoto S: Massive immunoglobulin treatment in women with five or more recurrent spontaneous primary abortions of unexplained aetiology. Hum Reprod 1998; 13:2620-2623.
8. Morikawa M, Yamada H, Kato EH, Shimada S, Kishida T, Yamada T, Kobashi G, Fujimoto S: Massive intravenous immunoglobulin treatment in women with four or more recurrent spontaneous abortions of unexplained etiology: Down-regulation of NK cell activity and subsets. Am J Reprod Immunol 2001; 46:399-404.
9. Aoki K, Kajiura S, Matsumoto Y, Ogasawara M, Okada S, Yagami Y, Gleicher N: Preconceptional natural-killer-cell activity as a predictor of miscarriage. Lancet 1995; 345:1340-1342.
10. Emmer PM, Veerhoek M, Nelen WL, Steegers EA, Joosten I: Natural killer cell reactivity and HLA-G in recurrent spontaneous abortion. Transplant Proc 1999; 31:1838-1840.
11. Higuchi K, Aoki K, Kimbara T, Hosoi N, Yamamoto T, Okada H: Suppression of natural killer cell activity by monocytes following immunotherapy for recurrent spontaneous aborters. Am J Reprod Immunol 1995; 33:221-227.
12. Kwak JY, Beaman KD, Gilman-Sachs A, Ruiz JE, Schewitz D, Beer AE: Up-regulated expression of CD56+, CD56+/CD16+, and CD19+ cells in peripheral blood lymphocytes in pregnant women with recurrent pregnancy losses. Am J Reprod Immunol 1995; 34:93-99.
13. Ruiz JE, Kwak JY, Baum L, Gilman-Sachs A, Beaman KD, Kim YB, Beer AE: Intravenous immunoglobulin inhibits natural killer cell activity in vivo in women with recurrent spontaneous abortion. Am J Reprod Immunol 1996; 35:370-375.
14. Kwak JY, Kwak FM, Ainbinder SW, Ruiz AM, Beer AE: Elevated peripheral blood natural killer cells are effectively downregulated by immunoglobulin G infusion in women with recurrent spontaneous abortions. Am J Reprod Immunol 1996; 35:363-369.
15. Yamada H, Kato EH, Kobashi G, Ebina Y, Shimada S, Sakuragi S, Fujimoto S: High NK cell activity in early pregnancy correlates with subsequent abortion with normal chromosomes in women with recurrent miscarriage. Am J Reprod Immunol 2001; 46:132-136.
16. Reinhard G, Noll A, Schlebusch H, Mallmann P, Ruecker AG: Shifts in the TH1/TH2 balance during human pregnancy correlate with apoptotic changes. Biochem Biophys Res Commun 1998; 245:933-938.
17. Hill JA, Polgar K, Anderson DJ: T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion. JAMA 1995; 273:1933-1936.
18. Szereday L, Spath P, Szekeres-Bartho J: Natural killer cell activity and cytokine production after in vitro immunoglobulin treatment of lymphocytes derived from pregnant women with or without risk for spontaneous abortion. Am J Reprod Immunol 1999; 42:282-287.
19. Suthanthiran M, Strom TB: Immunobiology and immunopharmacology of organ allograft rejection. J Clin Immunol 1995; 15:161-171.
20. Wegmann TG, Lin H, Guilbert L, Mosmann TR: Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a TH2 phenomenon? Immunol Today 1993; 14:353-356.
21. Lin H, Mosmann TR, Guilbert L, Tuntipopipat S, Wegmann TG: Synthesis of T helper 2-type cytokines at the maternal-fetal interface. J Immunol 1993; 151:4562-4573.
22. Gratacos E, Filella X, Palacio M, Cararach V, Alonso PL, Fortuny A: Interleukin-4, interleukin-10, and granulocyte-macrophage colony stimulating factor in second-trimester serum from women with preeclampsia. Obstet Gynecol 1998; 92:849-853.
23. Manolopoulos K, Lang U, Gips H, Braems GA: Elevated interleukin-10 and sex steroid levels in peritoneal fluid of patients with ovarian hyperstimulation syndrome. Eur J Obstet Gynecol Reprod Biol 2001; 99:226-231.
24. Makhseed M, Raghupathy R, Azizieh F, Farhat R, Hassan N, Bandar A: Circulating cytokines and CD30 in normal human pregnancy and recurrent spontaneous abortions. Hum Reprod 2000; 15:2011-2017.
25. Conrad KP, Miles TM, Benyo DF: Circulating levels of immunoreactive cytokines in women with preeclampsia. Am J Reprod Immunol 1998; 40:102-111.
26. Jenkins C, Roberts J, Wilson R, MacLean MA, Shilito J, Walker JJ: Evidence of a T (H) 1 type response associated with recurrent miscarriage. Fertil Steril 2000; 73:1206-1208.
27. Livingston JC, Park V, Barton JR, Elfering S, Haddad B, Mabie WC, Quasney M, Sibai BM: Lack of association of severe preeclampsia with maternal and fetal mutant alleles for tumor necrosis factor alpha and lymphotoxin alpha genes and plasma tumor necrosis factor alpha levels. Am J Obstet Gynecol 2001; 184: 1273-1277.
28. Bartha JL, Romero-Carmona R, Escobar-Llompart M, Comino-Delgado R: The relationships between leptin and inflammatory cytokines in women with preeclampsia. BJOG 2001; 108:1272-1276.
29. Maymon E, Ghezzi F, Edwin SS, Mazor M, Yoon BH, Gomez R, Romero R: The tumor necrosis factor alpha and its soluble receptor profile in term and preterm parturition. Am J Obstet Gynecol 1999; 181:1142-1148.
30. Gücer F, Balkanli-Kaplan P, Yuksel M, Sayin NC, Yuce MA, Yardim T: Maternal serum levels of tumor necrosis factor-alpha and interleukin-2 receptor in threatened abortion: A comparison with normal and pathologic pregnancies. Fertil Steril 2001; 76:707-711.
31. Daniel Y, Kupferminc MJ, Baram A, Jaffa AJ, Fait G, Wolman I, Lessing JB: Plasma interleukin-12 is elevated in patients with preeclampsia. Am J Reprod Immunol 1998; 39:376-380.
32. Russwurm GP, Mackler AM, Fagoaga OR, Brown WS 3rd, Sakala EP, Yellon SM, Nehlsen-Cannarella SL: Soluble human leukocyte antigens, interleukin-6, and interferon-gamma during pregnancy. Am J Reprod Immunol 1997; 38:256-262.
33. Nowak M, Oszukowski P, Szpakowski M, Malafiej E, Malinowski A, Wieczorek A, Wierzbicka E, Drzazga W: Maternal serum cytokines concentrations during normal pregnancy and labor. Ginekol Pol 1998; 69:1283-1287.
34. Kazatchkine MD, Kaveri SV: Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N Engl J Med 2001; 345:747-755.
35. Leung DY, Cotran RS, Kurt-Jones E, Burns JC, Newburger JW, Pober JS: Endothelial cell activation and high interleukin-1 secretion in the pathogenesis of acute Kawasaki disease. Lancet 1989; 2:1298-1302.
36. Sharief MK, Ingram DA, Swash M, Thompson EJ: I.v. immunoglobulin reduces circulating proinflammatory cytokines in Guillain-Barré syndrome. Neurology 1999; 52:1833-1838.
37. Aukrust P, Froland SS, Liabakk NB, Muller F, Nordoy I, Haug C, Espevik T: Release of cytokines, soluble cytokine receptors, and interleukin-1 receptor antagonist after intravenous immunoglobulin administration in vivo. Blood 1994; 8:2136-2143.
38. Pashov A, Dubey C, Kaveri SV, Lectard B, Huang YM, Kazatchkine MD, Bellon B. Normal immunoglobulin G protects against experimental allergic encephalomyelitis by inducing transferable T cell unresponsiveness to myelin basic protein. Eur J Immunol 1998; 28:1823-1831.
39. Saoudi A, Hurez V, De Kozak Y, Kuhn J, Kaveri SV, Kazacthkine MD, Druet P, Bellon B: Human immunoglobulin preparations for intravenous use prevent experimental autoimmune uveoretinitis. Int Immunol 1993; 5:1559-1567.
40. Polgar K, Hill JA: Identification of the white blood cell populations responsible for Th1 immunity to trophoblast and the timing of the response in women with recurrent pregnancy loss. Gynecol Obstet Invest 2002; 53:59-64.