Uptake of antineoplastic agents in pharmacy and hospital personnel. Part I: Monitoring of urinary concentrations

International Archives of Occupational and Environmental Health

Volumn 76, Issue 1, 2003, Pages 5-10

  Pethran, Angelika ^a   Schierl, Rudolf ^a,b   Hauff, Karlheinz ^a   Grim, Carl Heinz ^c   Boos, Karl Siegfried ^c   Nowak, Dennis ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b Inst/Poliklin Arbeits /Umweltmed   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Alkylating agents; Anthracyclines; Biological monitoring; Carboplatin; Cisplatin; Cytostatic drugs

Indexed keywords

ALKYLATING AGENT; ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; CYTOSTATIC AGENT; DOXORUBICIN; EPIRUBICIN; IFOSFAMIDE; PLATINUM;

ADULT; ARTICLE; BIOLOGICAL MONITORING; CANCER; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG CONTAMINATION; DRUG DETERMINATION; DRUG EXPOSURE; DRUG MONITORING; DRUG UPTAKE; DRUG URINE LEVEL; ENVIRONMENTAL MONITORING; GERMANY; HEALTH HAZARD; HOSPITAL DEPARTMENT; HOSPITAL HYGIENE; HOSPITAL PERSONNEL; HUMAN; LAMINAR AIRFLOW; MAJOR CLINICAL STUDY; OCCUPATIONAL DISEASE; OCCUPATIONAL EXPOSURE; PHARMACIST; PROTECTIVE CLOTHING; SAFETY; URINALYSIS; AIR CONDITIONING; FEMALE; MALE; MIDDLE AGED; URINE;

ADULT; ANTINEOPLASTIC AGENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; PERSONNEL, HOSPITAL; PHARMACISTS; VENTILATION;

EID: 0037607122     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Anwar WA, Salama SI, Serafy MME, Hemida SA, Hafez AS (1994) Chromosomal aberrations and micronucleus frequency in nurses occupationally exposed to cytotoxic drugs. Mutagenesis 9:315-317
2. Ensslin A, Pethran A, Schierl R, Fruhmann G (1994a) Urinary platinum in hospital personnel occupationally exposed to platinum-containing antineoplastic drugs. Int Arch Occup Environ Health 65:339-342
3. Ensslin A, Stoll Y, Pethran A, Pfaller A, Römmelt H, Fruhmann G (1994b) Biological monitoring of cyclophosphamide and ifosfamide in urine of hospital personnel occupationally exposed to cytostatic drugs. Occup Environ Med 51:229-233
4. Ensslin A, Huber R, Pethran A, et al. (1997) Biological monitoring of hospital pharmacy personnel occupationally exposed to cytostatic drugs: Urinary excretion and cytogenetics studies. Int Arch Occup Environ Health 70:205-208
5. Evelo CTA, Bos RP, Peters JGP, Henderson PT (1986) Urinary cyclophosphamide assay as a method for biological monitoring of occupational exposure to cyclophosphamide. Int Arch Occup Environ Health 58:151-155
6. Farago ME, Kavanagh P, Blanks R, Kelly J, Kazantzis G, Thornton I, et al. (1998) Platinum concentrations in urban road dust and soil, and in blood and urine in the United Kingdom. Analyst 123:451-454
7. Grimm CH, Books K-S (2001) Anthracycline cytostatic agents (doxorubicin, epirubicin, daunorubicin and idarubicin). In: Angerer J, Schaller KH (eds) Analyses of Hazardous Substances in Biological Materials, VCH Weinheim, pp 119-141
8. Grummt T, Grummt HJ, Schott G (1993) Chromosomal aberrations in peripheral lymphocytes of nurses and physicians handling antineoplastic drugs. Mutat Res 302:19-24
9. Hessel H, Radon K, Pethran A, Maisch B, Gröbmair S, Sautter I, Fruhmann G (2001) The genotoxic risk of hospital, pharmacy and medical personnel occupationally exposed to cytostatic drugs - Evaluation by the micronucleus assay. Mutat Res 497:101-109
10. Hirst M, Tse S, Mills DG, Levin L (1984) Occupational exposure to cyclophosphamide. Lancet 1:186-188
11. IARC (1981) Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 26. Some Antineoplastic and Immunosuppressive Agents. International Agency of Research on Cancer, Lyon, France
12. IARC (1986) Scientific Publications. No. 78: Carcinogenicity of Alkylating Cytostatic Drugs. International Agency of Research on Cancer, Lyon, France
13. IARC (1990) Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 50. Pharmaceutical Drugs. International Agency of Research on Cancer, Lyon, France
14. Lynge E (1994) Danish cancer registry as a resource for occupational research. J Occup Med 36: 1169-1173
15. Mader RM, Rizovski B, Wachter A, Kotz R, Rainer H (1996) Exposure of oncologic nurses to methotrexate in the treatment of osteosarcoma. Arch Environ Health 51:310-314
16. Messerschmidt J, Alt F, Tölg G, Angerer J, Schaller KH (1992) Adsorptive voltammetric procedure for the determination of platinum baseline levels in human body fluids. Fresenius J Anal Chem 343: 391-394
17. Minoia C, Turci R, Sottani C, et al. (1998) Application of high performance liquid chromatography/tandem mass spectrometry in the environmental and biological monitoring of health care personnel occupationally exposed to cyclophosphamide and ifosfamide. Rapid Commun Mass Spectrom 12:1485-1493
18. Nygren O, Lundgren C (1997) Determination of platinum in workroom air and in blood and urine from nursing staff attending patients receiving cisplatin chemotherapy. Int Arch Occup Environ Health 70: 209-214
19. Pethran A, Hauff K, Schierl R (1997) Biological monitoring of antineoplastic drugs in urine of hospital pharmacy technicians and personnel of oncology departments. J Oncol Pharm Pract 3:48-49
20. Pethran A, Hauff K, Hessel H, Grimm CH (1998) Biological, cytogenetic and ambient monitoring of exposure to antineoplastic drugs. J Oncol Pharm Pract 4:57
21. Pethran A, Schierl R, Schmaus G (2001) Wischproben an Arbeitsplätzen mit Zytostatika-Exposition. Krankenhauspharmazie 1:11-15
22. Philippeit G, Angerer J (1999) Innere Platinbelastung der Allgemeinbevölkerung. Umweltmed Forsch Prax 4:3-6
23. Pilger A, Köhler I, Stettner H, Mader RM, Rizovski B, Terkola R, Diem E, Franz-Heinzl E, Konnaris C, Valic E, Rüdiger HW (2000) Long-term monitoring of sister chromatid exchanges and micronucleus frequencies in pharmacy personnel occupationally exposed to cytostatic drugs. Int Arch Occup Environ Health 7:442-448
24. Schierl R (2001) Urinary platinum levels associated with dental gold alloys. Arch Environ Health 56:283-286
25. Schmaus G, Schierl R, Funck S (2002) Monitoring surface contamination by antineoplastic drugs using gas chromatography-mass spectrometry and voltammetry. Am J Health Syst Pharm 59:956-961
26. Schreiber C, Radon K, Pethran A, Schierl R, Hauff K, Grimm CH, Boos KS, Nowak D (2002) Incorporation of antineoplastic agents in pharmacy personnel - Study of work related risk factors. Int Arch Occup Environ Health 76:DOI 10.1007/s00420-002-0385-6
27. Sessink PJM, Anzion RBM, Van Den Broek PHH, Bos RP (1992) Detection of contamination with antineoplastic agents in a hospital pharmacy department. Pharm World Sci 14:16-22
28. Sessink PJM, Cerna M, Rössner P, Pastorkova A, Bavarova H, Frankova K, Anzion RBM, Bos RP (1994a) Urinary cyclophosphamide excretion and chromosomal aberrations in peripheral blood lymphocytes after occupational exposure to antineoplastic agents. Mutat Res 309:193-199
29. Sessink PJM, Timmersmann JL, Anzion RBM, Bos RP (1994b) Assessment of occupational exposure of pharmaceutical plant workers to 5-fluorouracil. J Occup Med 36:79-83
30. Sessink PJM, Van De Kerkhof MCA, Anzion RBM, Noordhoek J, Bos RP (199c) Environmental contamination and assessment of exposure to antineoplastic agents by determination of cyclophosphamide in urine of exposed pharmacy technicians: Is skin absorption an important exposure route? Arch Environ Health 49:165-169
31. Skov T, Lynge E, Maarup B, Olsen J, Roth M, Winthereik H (1990) Risks for physicians handling antineoplastic drugs. Lancet 336:1446
32. Skov T, Maarup B, Olsen J, Roth M, Winthereik H, Lynge E (1992) Leukaemia and reproductive outcome among nurses handling antineoplastic drugs. Br J Ind Med 49:855-861
33. Stücker I, Caillard JF, Collin R, et al. (1990) Risk of spontaneous abortion among nurses handling antineoplastic drugs. Scand J Work Environ Health 16:102-107
34. Stücker I, Mandereau L, Hémon D (1993) Relationship between birthweight and occupational exposure to cytostatic drugs during or before pregnancy. Scand J Work Environ Health 19:148-153
35. Valanis B, Vollmer W, Labuhn K, Glass A (1997) Occupational exposure to antineoplastic agents and self-reported infertility among nurses and pharmacists. J Occup Environ Med 39:574-580
36. Valanis B, Vollmer W, Steele P (1999) Occupational exposure to antineoplastic agents: Self-reported miscarriages and stillbirths among nurses and pharmacists. J Occup Environ Med 41:632-638