Effect of high glucose, angiotensin II and receptor antagonist Losartan on the expression of connective tissue growth factor in cultured mesangial cells

Chinese Medical Journal

Volumn 116, Issue 4, 2003, Pages 554-557

  Huang, Songmin ^a   Liu, Fang ^a   Sha, Zhaohui ^a   Fu, Ping ^a   Yang, Yifan ^a   Xu, Yong ^b   Zhou, Haiyan ^a  

^a SICHUAN UNIVERSITY   (China)

^b SOUTHWEST MEDICAL UNIVERSITY   (China)

Author keywords

Angiotensin II; Connective tissue growth factor; High glucose; Losartan; Mesangial cells; Renal fibrosis

Indexed keywords

ANGIOTENSIN; COMPLEMENTARY DNA; CONNECTIVE TISSUE GROWTH FACTOR; GLUCOSE; LOSARTAN; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SEQUENCE; GENE EXPRESSION; KIDNEY FIBROSIS; MESANGIUM CELL; NONHUMAN; RAT; RECEPTOR BLOCKING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; UPREGULATION;

ANGIOTENSIN II; ANIMALS; CELLS, CULTURED; GENE EXPRESSION; GLOMERULAR MESANGIUM; GLUCOSE; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LOSARTAN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 0037606025     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Madline M, Catherine G, Sarah C, et al. Supression Subtractine Hybridization Identifies High Glucose levels as a Stimulus for Expression of Connection Tissue Growth Factor and other Genes in Human Masangial Cells. J Biol Chem 1999;274:5830-5834.
2. Eunjoo H Lee, Cbown-ki Joo. Role of transforming growth factor-β in transdifferentiation and fibrosis of lens epithelial cells. Invest Opbthalmol Uis Sci 1999;40:2025-2027.
3. Border WA, Noble NA. Transforming growth factorβ in tissue fibrosis. N Engl J Med 1994;331:1286-1292.
4. Kitamura M, Suto TS. TGFβ and glomerulonephritis: Anti-inflammatory versus prosclerotic actions. Nephrol Dial Transplant 1997;12:669-679.
5. Bradham DM, Igarasgi A, Potter KL, et al. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells in related to the SKC-induced immediate early gene product CEF-10. J Cell Biol 1991;114: 1285-1292.
6. Ito Y, Kleij L, Alen J, et al. Connective tissue growth factor expression in the rat Thy1. 1 model and regulation in mesangial cell and podocytes. J Am Soc Nephrol 1997;8: 517A-519A.
7. Oemar BS, Werner A, Garnier JM, et al. Human connective tissue growth factor is expressed in advanced atherosclerotic lesions. Circulation 1997;95:831-839.
8. Igarashi A, Okochi H, Bradham DM, et al. Regulation of connective tissuue growth factor gene expression in human skin fibroblasts and during wound repair. Mol Biol Cell 1993;4:637-645.