Quantitative analysis of ES-285, an investigational marine anticancer drug, in human, mouse, rat, and dog plasma using coupled liquid chromatography and tandem mass spectrometry

Journal of Mass Spectrometry

Volumn 38, Issue 5, 2003, Pages 548-554

  Stokvis, E ^a   Nan Offeringa, L ^a   Rosing, H ^a   Lopez Lazaro L ^b   Acena J L ^b   Miranda, E ^b   Lyubimov, A ^c   Levine, B S ^c   D'Aleo, C ^d   Schellens, J H M ^a,e   Beijnen, J H ^a,e  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b PHARMAMAR S A   (Spain)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d PharmaMar USA Inc   (United States)

^e UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Anticancer drug; Bioanalysis; ES 285; Liquid chromatography electrospray ionization tandem mass spectrometry; Spisulosine

Indexed keywords

IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; PH EFFECTS; PROTEINS;

MARINE ANTICANCER DRUGS;

DRUG THERAPY;

ACETONITRILE; AMMONIUM FORMATE; ANTINEOPLASTIC AGENT; ES 285; METHANOL; PROTEIN; SPISULOSINE; UNCLASSIFIED DRUG; WATER;

ACCURACY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG SCREENING; DRUG STABILITY; ELUTION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOTOPE LABELING; MOUSE; NONHUMAN; PH; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; STANDARD; SUPERNATANT; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ALKANES; ANIMALS; ANTINEOPLASTIC AGENTS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; DRUG STABILITY; DRUGS, INVESTIGATIONAL; HUMANS; ISOTOPE LABELING; LIPIDS; MASS SPECTROMETRY; MICE; QUALITY CONTROL; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

CANIS FAMILIARIS;

EID: 0037603240     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/jms.469     Document Type: Article

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