Domestic radon risks may be dominated by bystander effects - But the risks are unlikely to be greater than we thought

Health Physics

Volumn 85, Issue 1, 2003, Pages 103-108

  Brenner, D J ^a   Sachs, R K ^b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

health effects; NCRP; radiation risk; radon

Indexed keywords

RADON;

ALPHA RADIATION; BYSTANDER EFFECT; CONFERENCE PAPER; DOSE RESPONSE; HUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION HAZARD;

NON-PROGRAMMATIC;

AIR POLLUTION, INDOOR; ALPHA PARTICLES; BYSTANDER EFFECT; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; LINEAR ENERGY TRANSFER; MODELS, BIOLOGICAL; RADIOMETRY; RADON DAUGHTERS; RISK ASSESSMENT;

EID: 0037600691     PISSN: 00179078     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004032-200307000-00018     Document Type: Conference Paper

References (20)

1. Adamson IYR. Cellular kinetics of the lung. In: Witschi HP, Brain JP, eds. Toxicology of inhaled materials. Berlin: Springer-Verlag; 1985: 289-317.
2. Belyakov OV, Malcolmson AM, Folkard M, Prise KM, Michael BD. Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts. Brit J Cancer 84:674-679; 2001.
3. Brenner DJ. The significance of dose rate in assessing the hazards of domestic radon exposure. Health Phys 67:76-79; 1994.
4. Brenner DJ, Little JB, Sachs RK. The bystander effect in radiation oncogenesis II A quantitative model. Radiat Res 155:402-408; 2001.
5. Brenner DJ, Sachs RK. Protraction effects in radiation studies: Basic biophysics. Radiat Res 154:736-737; 2000.
6. Brenner DJ, Sachs RK. Do low dose-rate bystander effects influence domestic radon risks? Int J Radiat Biol 78:593-604;2002.
7. Cross FT. A review of experimental animal radon health effects data. In: Chapman JD, Dewey WC, Whitmore GF, eds. Radiation research: a twentieth-century perspective. Vol II. San Diego: Academic Press; 1992: 476-481.
8. Gilbert ES, Cross FT, Dagle GE. Analysis of lung tumor risks in rats exposed to radon. Radiat Res 145:350-360; 1996.
9. Goldberg Z, Lehnert BE. Radiation-induced effects in unirradiated cells: A review and implications in cancer. Int J Oncol 21:337-349; 2002.
10. Hall EJ. The bystander effect. Health Phys 85:31-35; 2003.
11. Lubin JH, Boice JD Jr, Hornung RW, Edling C, Howe G, Kunz E, Kusiak RA, Morrison HI, Radford EP, Samet JM, Tirmarche M, Woodward A, Xiang YS, Pierce DA. Radon and lung cancer risk: A joint analysis of 11 underground miner studies. Bethesda, MD: National Institutes of Health; Publication No 94-3644; 1994.
12. Lubin JH, Boice JD Jr, Edling C, Hornung RW, Howe G, Kunz E, Kusiak RA, Morrison HI, Radford EP, Samet JM, Tirmarche M, Woodward A, Xiang YS, Pierce DA. Radonexposed underground miners and inverse dose-rate (protraction enhancement) effects. Health Phys 69:494-500; 1995.
13. Miller RC, Randers-Pehrson G, Geard CR, Hall EJ, Brenner DJ. The oncogenic transforming potential of the passage of single alpha particles through mammalian cell nuclei. Proc Natl Acad Sci USA 96:19-22; 1999.
14. Monchaux G, Morlier JP, Altmeyer S, Debroche M, Morin M. Influence of exposure rate on lung cancer induction in rats exposed to radon progeny. Radiat Res 152(Suppl 6):S137-140; 1999.
15. Mothersill C, Seymour C. Radiation-induced bystander effects: past history and future directions. Radiat Res 155:759-767; 2001.
16. National Council on Radiation Protection and Measurements. Ionizing radiation exposure of the population of the United States. Bethesda, MD: NCRP; Report No. 93; 1987.
17. National Research Council. Health effects of exposure to radon: BEIR VI. Committee on the Health Risks of Exposure to Radon. Washington DC: National Academy Press; 1999.
18. Rossi HH, Hall EJ, Zaider M. The role of neutrons in transformation research. I: Theory. In: Broerse JJ, Gerber GB, eds. Luxembourg: Commission of the European Communities; Report EUR 8084; 1982: 371-380.
19. Sawant S, Randers-Pehrson G, Geard CR, Brenner DJ, Hall EJ. The bystander effect in radiation oncogenesis. I; Transformation in C3H10T1/2 cells in vitro can be activated in the unirradiated neighbors of irradiated cells. Radiat Res 155:397-401; 2001.
20. Zhou H, Suzuki M, Randers-Pehrson G, Vannais D, Chen G, Trosko JE, Waldren CA, Hei TK. Radiation risk to low fluences of alpha particles may be greater than we thought. Proc Natl Acad Sci USA 98:14410-14415; 2001.