Dynamic simulation of pollutant effects on the threonine pathway in Escherichia coli

Comptes Rendus - Biologies

Volumn 326, Issue 5, 2003, Pages 501-508

  Chassagnole, Christophe ^a   Quentin, Éric ^a,d   Fell, David A ^b   de Atauri, Pedro ^c   Mazat, Jean Pierre ^a  

^a INSERM   (France)

^b OXFORD BROOKES UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF BARCELONA   (Spain)

^d DIOSYNTH France   (France)

Author keywords

Biosynthetic pathway; Computer simulation; Metabolic control analysis; Pollutants; Threonine

Indexed keywords

ASPARTATE SEMIALDEHYDE DEHYDROGENASE; CADMIUM; COPPER; ENZYME INHIBITOR; HEAVY METAL; MERCURY; NITRATE; NITRITE; THREONINE; ZINC;

METABOLISM; MICROBIOLOGY; POLLUTION;

AMINO ACID METABOLISM; ARTICLE; BACTERIAL METABOLISM; BIOLOGICAL MODEL; CALCULATION; CHEMICAL PARAMETERS; COMPUTER SIMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION COEFFICIENT; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; MOLECULAR DYNAMICS; NONHUMAN; POLLUTANT; QUANTITATIVE ANALYSIS;

ESCHERICHIA COLI;

EID: 0037589672     PISSN: 16310691     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1631-0691(03)00098-2     Document Type: Article

References (16)

1. C. Chassagnole, B. Raïs, E. Quentin, D.A. Fell, J.-P. Mazat, An integrated study of threonine pathway enzyme kinetics in Escherichia coli, Biochem. J. 356 (2001) 415-423.
2. B. Raïs, C. Chassagnole, T. Letellier, D.A. Fell, J.-P. Mazat, Threonine synthesis from aspartate in Escherichia coli cell-free extracts: pathway dynamics, Biochem. J. 356 (2001) 425-432.
3. C. Chassagnole, D.A. Fell, B. Raïs, B. Kudla, J.-P. Mazat, Control of the threonine synthesis pathway in Escherichia coli: a theoretical and experimental approach, Biochem. J. 356 (2001) 433-444.
4. G.N. Cohen, Le métabolisme cellulaire et sa régulation, Hermann, Paris, 1967.
5. F.C. Neidhardt, Escherichia coli and Salmonella typhimurium, Cellular and Molecular Biology, American Society for Microbiology, Washington DC, 1987.
6. H. Kacser, J.A. Burns, The control of flux, Symp. Soc. Exp. Biol. 27 (1973) 65-104, reprinted in Biochem. Soc. Trans. 23 (1995) 341-366.
7. D.A. Fell, Metabolic control analysis: a survey of its theoretical and experimental developments, Biochem. J. 286 (1992) 313-330.
8. D.A. Fell, Understanding the Control of Metabolism, Portland Press, London, 1997.
9. R. Heinrich, T.A. Rapoport, A linear steady-state treatment of enzymatic chains; general properties, control and effector strength, Eur. J. Biochem. 42 (1974) 89-95.
10. C. Reder, Metabolic control theory: a structural approach, J. Theor. Biol. 135 (1988) 175-201.
11. A. Szentirmai, M. Szentirmai, H.E. Umbarger, Isoleucine and valine metabolism properties of Escherichia coli XV. Biochemical properties of mutants resistant to thiaisoleucine, J. Bacteriol. 95 (1968) 1672-1679.
12. M. Szczesiul, D.E. Wampler, Regulation of a metabolic system in vitro: synthesis of threonine from aspartate, Biochemistry 15 (1976) 2236-2244.
13. H.M. Sauro, Control Analysis and simulation of metabolism, PhD thesis, Oxford Polytechnic, 1986.
14. H.M. Sauro, D.A. Fell, SCAMP: a metabolic simulator and control analysis program, Math. Comput. Model. 15 (1991) 15-28.
15. H.M. Sauro, SCAMP: a general-purpose simulator and metabolic control analysis program, CABIOS 9 (1993) 441-450.
16. D.A. Fell, H.M. Sauro, Metabolic control analysis by computer: progress and prospects, Biomed. Biochim. Acta 49 (1990) 811-816.