Recently Identified Molecular Aspects of Intestinal Iron Absorption

Journal of Nutrition

Volumn 130, Issue 1 SUPPL., 2000, Pages 1841-1844

  Wood, Richard J ^a   Han, Okhee ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

DCT1; Hemochromatosis; HFE; Membrane transporters; Nramp2

Indexed keywords

EID: 0037579521     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Anderson, G. J., Murphy, T. L., Cowley, L., Evans, B. A., Halliday, J. W. & McLaren, G. D. (1998) Mapping the gene for sex-linked anemia: an inherited defect of intestinal iron absorption in the mouse. Genomics 48: 34-39.
2. Andrews, N. C. (1997) Iron deficiency: lessons from anemic mice. Yale J. Biol. Med. 70: 219-226.
3. Askwith, C. C., de Silva, D. & Kaplan, J. (1996) Molecular biology of iron acquisition in Saccharomyces cerevisiae. Mol. Microbiol. 20: 27-34.
4. Bannerman, R. M. (1976) Genetic defects of iron transport. Fed. Proc. 35: 2281-2285..
5. Bronner, F. (1998) Calcium absorption - a paradigm for mineral absorption. J. Nutr. 128: 917-920.
6. Conrad, M. E. & Umbreit, J. N. (1993) A concise review: iron absorption - the mucin-mobilferrin-integrin pathway. A competitive pathway for metal absorption. Am. J. Hematol. 42: 67-73.
7. Conrad, M. E., Umbreit, J. N., Peterson, R. D., Moore, E. G. & Harper, K. P. (1993) Function of integrin in duodenal mucosal uptake of iron. Blood 81: 517-521.
8. Dancis, A., Yuan, D. S., Haile, D., Askwith, C., Elde, D., Moehle, C., Kaplan, J. & Klausner, R. D. (1994) Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport. Cell 76: 393-402.
9. Ekmekcioglu, C., Feyertag, J. & Marktl, W. (1996) A ferric reductase activity is found in brush border membrane vesicles isolated from Caco-2 cells. J. Nutr. 126: 2209-2217.
10. Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R., Jr., Ellis, M. C., Fullan, A., Hinton, L. M., Jones, N. L., Kimmel, B. E., Kronmal, G. S., Lauer, P., Lee, V. K., Loeb, D. B., Mapa, F. A., McClelland, E., Meyer, N. C., Mintier, G. A., Moeller, N., Moore, T., Morikang, E., Wolff, R. K. et al. (1996) A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat. Genet. 13: 399-408.
11. Feder, J. N., Penny, D. M., Irrinki, A., Lee, V. K., Lebron, J. A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P. J. & Schatzman, R. C. (1998) The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc. Natl. Acad. Sci. USA 95: 1472-1477.
12. Feder, J. N., Tsuchihashi, Z., Irrinki, A., Lee, V. K., Mapa, F. A., Morikang, E., Prass, C. E., Starnes, S. M., Wolff, R. K., Parkkila, S., Sly, W. S. & Schatzman, R. C. (1997) The hemochromatosis founder mutation in HLA-H disrupts beta-2 microglobulin interaction and cell surface expression. J. Biol. Chem. 272: 14025-14028.
13. Fleming, M. D., Romano, M. A., Su, M. A., Garrick, L. M., Garrick, M. D. & Andrews, N. C. (1998) Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc. Natl. Acad. Sci. USA 95: 1148-1153.
14. Fleming, M. D., Trenor, C. C., III, Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F. & Andrew, N. C. (1997) Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat. Genet. 16: 383-386.
15. Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L. & Hediger, M. A. (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388: 482-488.
16. Gutierrez, J. A., Yu, J., Rivera, S. & Wessling-Resnick, M. (1997) Functional expression cloning and characterization of SFT, a stimulator of Fe transport. J. Cell Biol. 139: 895-905.
17. Han, O., Failla, M. L., Hill, A. D., Morris, E. R. & Smith, J. C., Jr. (1995) Reduction of Fe(III) is required for uptake of nonheme iron by Caco-2 cells. J. Nutr. 125: 1291-1299.
18. Han, O., Fleet, J. & Wood, R. (1998) Reciprocal regulation of HFE and Nramp2 gene expression by iron in human intestinal cells. FASEB J. 12: A280. (abst).
19. McMahon, R. J. & Cousins, R. J. (1998) Mammalian zinc transporters. J. Nutr. 128: 667-670.
20. +3 uptake by transformed human intestinal epithelial (Caco-2) cells. Am. J. Physiol. 267: C1582-1588.
21. Parkkila, S., Waheed, A., Britton, R. S., Bacon, B. R., Zhou, X. Y., Tomatsu, S., Fleming, R. E. & Sly, W. S. (1997) Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis. Proc. Natl. Acad. Sci. USA 94: 13198-13202.
22. Patel, B. N. & David, S. (1997) A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes. J. Biol. Chem. 272: 20185-20190.
23. Reidel, H. D., Remus, A. J., Fitscher, B. A. & Stremmel, W. (1995) Characterization and partial purification of a ferrireductase from human duodenal microvillus membranes. Biochem. J. 309: 745-748.
24. Rothenberg, B. E. & Voland, J. R. (1996) Beta-2 knockout mice develop parenchymal iron overload: a putative role for class I genes of the major histocompatibility complex in iron metabolism. Proc. Natl. Acad. Sci. USA 93: 1529-1534.
25. Teichmann, R. & Stremmel, W. (1990) Iron uptake by human upper small intestine microvillus membrane vesicles. Indication for a facilitated transport mechanism mediated by a membrane iron-binding protein. J. Clin. Invest. 86: 2145-2153.
26. Yu, J. & Wessling-Resnick, M. (1998) Influence of copper depletion on iron uptake mediated by SFT, a stimulator of Fe transport. J. Biol. Chem. 273: 6909-6915.
27. Yuan, D. S., Stearman, R., Dancis, A., Dunn, T., Beeler, T. & Klausner, R. D. (1995) The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake. Proc. Natl. Acad. Sci. USA 92: 2632-2636.
28. Zhou, B. & Gitschier, J. (1997) hCTR1: a human gene for copper uptake identified by complementation in yeast. Proc. Natl. Acad. Sci. USA 94: 7481-7486.
29. Zhou, X. Y., Tomatsu, S., Fleming, R. E., Parkkila, S., Waheed, A., Jiang, J., Fei, Y., Brunt, E. M., Ruddy, D. A., Prass, C. E., Schatzman, R. C., O'Neill, R., Britton, R. S., Bacon, B. R. & Sly, W. S. (21998) HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc. Natl. Acad. Sci. USA 95: 2492-2497.