Protein inhibitors of serine proteinases: Role of backbone structure and dynamics in controlling the hydrolysis constant

Biochemistry

Volumn 42, Issue 18, 2003, Pages 5186-5194

  Song, Jikui ^a   Markley, John L ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN INHIBITORS;

DISSOCIATION; HYDROLYSIS; NUCLEAR MAGNETIC RESONANCE; PH EFFECTS; SUBSTITUTION REACTIONS; SUBSTRATES;

PROTEINS;

AMINO ACID; CARBOXYLIC ACID DERIVATIVE; HISTIDINE; INDIAN PEAFOWL OVOMUCOID THIRD DOMAIN; NITROGEN 15; OVOMUCOID; PEPTIDE; PROTEIN INHIBITOR; SERINE PROTEINASE; TURKEY OVOMUCOID THIRD DOMAIN; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; ENTHALPY; ENTROPY; ENZYME BINDING; ENZYME MECHANISM; HYDROGEN BOND; HYDROLYSIS; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE;

ANIMALS; BINDING SITES; ESCHERICHIA COLI; HYDROGEN BONDING; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN FOLDING; RECOMBINANT FUSION PROTEINS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS;

PAVO CRISTATUS;

EID: 0037544305     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034041u     Document Type: Article

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