A longitudinal study of α1-antitrypsin phenotypes and decline in FEV1 in a community population

Chest

Volumn 123, Issue 5, 2003, Pages 1435-1440

  Silva, Graciela E ^a   Sherrill, Duane L ^a,c   Guerra, Stefano ^a,b   Barbee, Robert A ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

Asthma; Chronic bronchitis; Protease inhibitors; Pulmonary emphysema; Trypsin inhibitors; 1 antitrypsin

Indexed keywords

ALPHA 1 ANTITRYPSIN; PROTEINASE INHIBITOR;

ADULT; ALPHA ANTITRYPSIN DEFICIENCY; ARTICLE; ASTHMA; CHRONIC BRONCHITIS; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LUNG EMPHYSEMA; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PHENOTYPE; POPULATION RESEARCH; PRIORITY JOURNAL; QUESTIONNAIRE; UNITED STATES; AGED; ALPHA 1 ANTITRYPSIN DEFICIENCY; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; GENETICS; LONGITUDINAL STUDY; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; RISK FACTOR; SMOKING;

ADULT; AGED; ALPHA 1-ANTITRYPSIN DEFICIENCY; COHORT STUDIES; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; LONGITUDINAL STUDIES; LUNG DISEASES, OBSTRUCTIVE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PHENOTYPE; PROSPECTIVE STUDIES; RISK FACTORS; SMOKING;

EID: 0037541112     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.123.5.1435     Document Type: Article

References (24)

1. World Health Organization. Alpha 1-antitrypsin deficiency: memorandum from a WHO meeting. Bull World Health Organ 1997; 75:307-313
2. 1-antitrypsin deficiency. Acta Med Scand 1963; 175:197-205
3. 1-antitrypsin deficiency in patients with pulmonary emphysema. N Engl J Med 1969; 281:279-284
4. Kueppers F, Fallat R, Larson RK. Obstructive lung disease and alpha-1-antitrypsin deficiency gene heterozygosity. Science 1969; 165:899-901
5. 1-antitrypsin heterozygote controversy. Am Rev Respir Dis 1976; 113:601-606
6. Cooper DM, Hoeppner V, Cox D, et al. Lung function in alpha1-antitrypsin heterozygotes (Pi type MZ). Am Rev Respir Dis 1974; 110:708-715
7. Lieberman J, Winter B, Sastre A, Alpha 1-antitrypsin Pi-types in 965 COPD patients. Chest 1986; 89:370-373
8. 1 antitrypsin heterozygocity and chronic obstructive pulmonary disease. Am Rev Respir Dis 1971; 103:874-875
9. Morse JO, Lebowitz MD, Knudson RJ, et al. A community study of the relation of alpha1-antitrypsin levels to obstructive lung diseases. N Engl J Med 1975; 292:278-281
10. Cole RB, Nevin NC, Blundell G, et al. Relation of alpha-1-antitrypsin phenotype to the performance of pulmonary function tests and to the prevalence of respiratory illness in a working population. Thorax 1976; 31:149-157
11. Morse JO, Lebowitz MD, Knudson RJ, et al. Relation of protease inhibitor phenotypes to obstructive lung diseases in a community. N Engl J Med 1977; 296:1190-1194
12. Lebowitz MD, Knudson RJ, Morse JO, et al. Closing volume and flow volume abnormalities in alpha(1)-antitrypsin phenotype groups in a community population. Am Rev Respir Dis 1978; 117:179-181
13. Buist AS, Sexton GJ, Azzam AH, et al. Pulmonary function in heterozygotes for alpha, -antitrypsin deficiency: a case-control study. Am Rev Respir Dis 1979; 120:759-766
14. Gulsvik A, Fagerhol MK. Alpha 1-antitrypsin phenotypes and obstructive lung disease in the city of Oslo. Stand J Respir Dis 1979; 60:267-274
15. Horne SL, Chen Y, Cockcroft DW, et al. Risk factors for reduced pulmonary function in women: a possible relationship between Pi phenotype, number of children, and pulmonary function. Chest 1992; 102:158-163
16. Horton FO III, Mackenthun AV, Anderson PS, et al. Alpha 1 antitrypsin heterozygotes (Pi type MZ): a longitudinal study of the risk of development of chronic air flow limitation. Chest 1980; 77:261-264
17. Madison R, Mittman C, Afifi AA, et al. Risk factors for obstructive lung disease. Am Rev Respir Dis 1981; 124:149-153
18. de Hamel FA, Carrell RW. Heterozygous alpha 1-antitrypsin deficiency: a longitudinal lung function study. N Z Med J 1981; 94:407-410
19. Janus ED. Alpha 1-antitrypsin Pi types in COPD patients. Chest 1988; 94:446-447
20. Sandford AJ, Chagani T, Weir TD, et al. Susceptibility genes for rapid decline of lung function in the Lung Health Study. Am J Respir Crit Care Med 2001; 163:469-473
21. Lebowitz MD, Knudson RJ, Burrows B. Tucson epidemiologic study of obstructive lung diseases. I: Methodology and prevalence of disease. Am J Epidemiol 1975; 102:137-152
22. American Thoracic Society. ATS statement: snowbird workshop on standardization of spirometry. Am Rev Respir Dis 1979; 119:831-838
23. Fagerhol MK, Laurell CB. The polymorphism of "prealbumins" and alpha-1-antitrypsin in human sera. Clin Chim Acta 1967; 16:199-903
24. Knudson RJ, Lebowitz MD, Holberg CJ, et al. Changes in the normal maximal expiratory flow-volume curve with growth and aging. Am Rev Respir Dis 1983; 127:725-734