An Alternative to DEHP Plasticized Polyvinyl Chloride in Chemotherapy Drug Delivery Systems

Journal of Vinyl and Additive Technology

Volumn 2, Issue 4, 1996, Pages 314-320

  Czuba, Len ^a   Puryear, Harry ^b   Sarkar, Kamal ^b  

^a Czuba Enterprises   (United States)

^b SIMS Deltec   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0037540274     PISSN: 01937197     EISSN: None     Source Type: Journal    
DOI: 10.1002/vnl.10147     Document Type: Article

References (14)

1. E. K. Rowinsky, L. A. Cazenave, R. C. Donehower, et al. Taxol: a novel investigational antimicrotubule agent. J. Natl. Cancer Inst., 82, 1247-1259 (1990).
2. E. K. Rowinsky, N. Onetto, R. M. Canetta, et al. Taxol: the first of the taxanes, an important new class of antitumor agents. Semin Oncol., 19, 646-662 (1992).
3. Bristol-Myers Squibb Company, Taxol (paclitaxel) Administration Guide and Package Insert, 1993.
4. D. Calley, J. Autian, W. L. Guess. Toxicology of a Series of Phthalate Esters. J. Pharm. Sci., 55, 158-162 (1966).
5. P. Moorhatch, W. L. Chiou. Interactions between drugs and plastic intravenous fluid bags. Am. J. Hosp. Pharm., 31, 149-152 (Feb. 1974).
6. R. Venkatarmanan, R. Burckart, et al. Leaching of diethylhexyl phthalate from polyvinyl chloride. Am. J. Hosp. Pharm., 43, 2800-2802 (Nov. 1986).
7. W. Waugh, L Trissel, V. Stella. Stability, compatibility, and plasticizer extraction of taxol (NSC-125973) injection diluted in infusion solutions and stored in various containers. Am. J. Hosp. Pharm., 48, 1520-1524 (1991).
8. J. A. Thomas, M. J. Thomas. Biological effects of di-(2-ethylhexyl) phthalate and other phthalic acid esters. Critical Reviews in Toxicology, 13, 4:283-317, CRC Press Inc. (1984).
9. P. J. Garvin, J. G. Schmidt, R. F. Wallin. Safety evaluation of plasma solutions of di-(2-ethylhexyl) phthalate injected intravenously in rats. Toxicol. Appl. Pharmacol. 37, 99 (1976).
10. J. R. Warren, N. D. Lalwani, J. K. Reddy. Phthalate esters as peroxisome proliferator carcinogens. Environ. Health Perspect., 45, 35-40 (1982).
11. G. M. Pollack, J. F. Slaughter, J. F. Buchanan, D. D. Shen. High-performance liquid chromatographic procedure for the determination of di-(2-ethylhexyl)phthalate in human blood specimens. Journal of Chromatography, 311, 101-108 (1984).
12. M. C. Allwood. The release of phthallate ester plasticizer from intravenous administration sets into fat emulsion. International Journal of Pharmaceutics, 29, 233-236 (1986).
13. J. H. Corley, T. E. Needham, E. D. Sumner, R. Mikeal. Effect of various factors on the amount of plasticizer in intravenous solutions packaged in flexible bags. Am. J. Hosp. Pharm., 34, 259-264 (1977).
14. G. W. Harris. Di (2-ethylhexyl) phthalate (DEHP) in medical products. Presentation given at the June 1981 National Toxicology Program on Phthalates.