Treatment and prevention of thromboembolism after spinal cord injury

Topics in Spinal Cord Injury Rehabilitation

Volumn 9, Issue 1, 2003, Pages 14-25

  Chen, David ^a  

^a Rehabilitation Institute   (United States)

Author keywords

Deep vein thrombosis; Pulmonary embolism; Spinal cord injury; Thromboembolism

Indexed keywords

HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; WARFARIN;

BLEEDING; CLINICAL FEATURE; CLINICAL TRIAL; DEEP VEIN THROMBOSIS; DIAGNOSTIC APPROACH ROUTE; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG HALF LIFE; DRUG MECHANISM; HUMAN; LEG COMPRESSION; LOW DRUG DOSE; LUNG EMBOLISM; MOBILIZATION; OSTEOPOROSIS; PROPHYLAXIS; REVIEW; RISK FACTOR; SPINAL CORD INJURY; THROMBOCYTOPENIA; THROMBOEMBOLISM; VENA CAVA FILTER;

EID: 0037531617     PISSN: 10820744     EISSN: None     Source Type: Journal    
DOI: 10.1310/FQB8-X0G3-NT9N-QMVL     Document Type: Review

References (64)

1. Tribe CR. Causes of death in early and late stages in paraplegia. Paraplegia. 1963;1:19-47.
2. Walsh JJ, Tribe C. Phlebo-thrombosis and pulmonary embolism in paraplegia. Paraplegia. 1965;3:209-213.
3. Watson N. Anticoagulation therapy in prevention of venous thrombosis and pulmonary embolism in spinal cord injury. Paraplegia. 1968;6:113-121.
4. Watson N. Anticoagulant therapy in the treatment of venous thrombosis and pulmonary embolism in acute spinal cord injury. Paraplegia. 1974;12:197-201.
5. Chen D, Apple DA, Hudson LM, Bode R. Medical complications during acute rehabilitation following spinal cord injury - current experience of the model systems. Arch Phys Med Rehabil. 1999;80:1397-1401.
6. Geerts WH, Code KI, Jay RM, Chen E, Szalai JP. A prospective study of venous thromboembolism after major trauma. New Engl J Med. 1994;331:1601-1606.
7. Todd JW, Frisbie JH, Rossier AB, et al. Deep venous thrombosis in acute spinal cord injury: comparison of 125 I fibrinogen leg scanning, impedance plethysmography and venography. Paraplegia. 1976;14:50-57.
8. Myllynen P, Kammonen M, Rokkanen P, et al. Deep venous thrombosis and pulmonary embolism in patients with acute spinal cord injury: a comparison with non-paralyzed patients immobilized due to spinal fractures. J Trauma. 1985;25:541-546.
9. Merli G, Herbison G, Ditunno J, et al. Deep vein thrombosis: prophylaxis in acute spinal cord injured patients. Arch Phys Med Rehabil. 1988;69:661-664.
10. Petaja J, Myllynen P, Rokkanen P, et al. Fibrinolysis and spinal injury: relationships to posttraumatic deep vein thrombosis. Acta Chiruga Scandinavia. 1989;155:241-246.
11. Yelnik A, Dizien O, Bussel B, et al. Systemic lower limb phlebography in acute spinal cord injury in 147 patients. Paraplegia. 1991;29:253-260.
12. Gunduz S, Ogur E, Mohur H, et al. Deep vein thrombosis in spinal injured patients. Paraplegia. 1993;31:606-610.
13. Ragnarsson K, Hall KM, Wilmot CB, et al. Management of pulmonary, cardiovascular, and metabolic conditions after spinal cord injury. In: Stover S, DeLisa JA, Whiteneck GG, eds. Spinal Cord Injury: Clinical Outcomes from the Model Systems. Gaithersburg: Aspen Publishers; 1995:79-99.
14. Hirsh J, Hull RD. Venous Thromboembolism: Natural History, Diagnosis, and Management. Boca Raton: CRC Press; 1987.
15. Weingarden DS, Weingarden SI, Belen J. Thromboembolic disease presenting as fever in spinal cord injury. Arch Phys Med Rehabil. 1987;68:176-177.
16. Frieden RA, Ahn JH, Pineda HD, et al. Venous plethysmography values in patients with spinal cord injury. Arch Phys Med Rehabil. 1987;169:427-429.
17. Davidson BL, Elliott CG, Lensing AWA. Low accuracy of color Doppler ultrasound in the detection of proximal leg vein thrombosis in asymptomatic high-risk patients. Ann Int Med. 1992;117:735-738.
18. Bounameaux H, de Moerloose P, Perrier A, Reber G. Plasma measurement of d-dimer as diagnostic aid in suspected venous thromboembolism: an overview. Thromb Haemost. 1994;71:1-6.
19. Williams JE, Marshall MW. Vascular radiology. In: Brant WE, Helms CA, eds. Fundamentals of Diagnostic Radiology. 2nd ed. Philadelphia: Lippincott, Williams & Wilkins; 1999:571-613.
20. The PIOPED Investigators. Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). JAMA. 1990;263:2753-2759.
21. Rathbun SW, Raskob GE, Whitsett TL. Sensitivity and specificity of helical computed tomography in the diagnosis of pulmonary embolism: a systematic review. Ann Intern Med. 2000;132:227-232.
22. Mullins MD, Becker DM, Hagspiel KD, Philbrick JT. The role of spiral volumetric computed tomography in the diagnosis of pulmonary embolism. Arch Intern Med. 2000;160:293-298.
23. Ost D, Rozenshtein A, Saffran L, Snider A. The negative predictive value of spiral computed tomography for the diagnosis of pulmonary embolism in patients with nondiagnostic ventilation-perfusion scans. Am J Med. 2001;110:16-21.
24. Hull RD, Raskob GE, Rosenbloom DR, et al. Optimal therapeutic level of heparin therapy in patients with venous thrombosis. Arch Intern Med. 1992;152:1589-1595.
25. Raschke RA, Reilly BM, Guidry JR, et al. The weight based heparin dosing nomogram compared with a "standard care" nomogram. Ann Intern Med. 1993;119:874-881.
26. Hull RD, Raskob GE, Brant RF, et al. The importance of initial heparin treatment on long-term clinical outcomes of antithrombotic therapy. Arch Intern Med. 1997;157:2317-2321.
27. Hull RD, Raskob GE, Brant RF, et al. Relation between the time to achieve the lower limit of the aPTT therapeutic range and recurrent venous thromboembolism during heparin treatment for deep vein thrombosis. Arch Intern Med. 1997;157:2562-2568.
28. Andersson LO, Barrowcliffe TW, Holmer E, et al. Molecular weight dependency of the heparin potentiated inhibition of thrombin and activated factor X. Effect of heparin neutralization in plasma. Thromb Res. 1979;15:531-541.
29. Barrowcliffe TW, Curtis AD, Johnston EA, et al. An international standard for low molecular weight heparin. Thromb Haemost. 1988;60:1-7.
30. Fareed J, Walenga JM, Racanelli A, et al. Validity of the newly established low molecular weight heparin standard in cross referencing low molecular weight heparins. Haemostasis. 1988;3(suppl):33-47.
31. Hirsh J, Levine MN. Low molecular weight heparin. Blood. 1992:79:1-17.
32. Lensing AW, Prins MH, Davidson BL, et al. Treatment of deep venous thrombosis with low molecular weight heparins. Arch Intern Med. 1995;155:601-607.
33. Shaughnessy SG, Young E, Deschamps P, Hirsh J. The effects of low molecular weight and standard heparin on calcium loss from fetal rat calvaria. Blood. 1995;86:1368-1373.
34. Warkentin TE, Levine MN, Hirsh J, et al. Heparin induced thrombocytopenia in patients treated with low molecular weight heparin or unfractionated heparin. N Engl J Med. 1995;332:1330-1335.
35. Hull RD, Raskob GE, Pineo GF, et al. Subcutaneous low molecular weight heparin compared with continuous intravenous heparin in the treatment of proximal vein thrombosis. N Engl J Med. 1992;326:975-988.
36. Prandoni P, Lensing AW, Buller HR, et al. Comparison of subcutaneous low molecular weight heparin with intravenous standard heparin in proximal deep vein thrombosis. Lancet. 1992;339:441-445.
37. Lopaciuk S, Meissner AJ, Filipecki S, et al. Subcutaneous low molecular weight heparin versus subcutaneous unfractionated heparin in the treatment of deep vein thrombosis. A Polish multicentre trial. Thromb Haemost. 1992;68:14-18.
38. Simonneau G, Charbonnier B, Decousus H, et al. Subcutaneous low molecular weight heparin compared with continuous intravenous unfractionated heparin in the treatment of proximal deep vein thrombosis. Arch Intern Med. 1993;153:1541-1546.
39. Lindmarker P, Holmstrom M, Granqvist S, et al. Comparison of once-daily subcutaneous Fragmin with continuous intravenous unfractionated heparin in the treatment of deep venous thrombosis. Thromb Haemost. 1994;72:186-190.
40. Simonneau G, Sors H, Charbonnier B, et al. A comparison of low molecular weight heparin with unfractionated heparin for acute pulmonary embolism. N Engl J Med. 1997;337:663-669.
41. The Columbus Investigators. Low molecular weight heparin in the treatment of patients with venous thromboembolism. N Engl J Med. 1997;337:657-662.
42. Green D. Venous thromboembolism. In: Green D, ed. Medical Management of Long-Term Disability. 2nd ed. Boston, MA: Butterworth-Heinemann; 1996.
43. Hirsh J, Dalen JE, Anderson DR, et al. Oral anticoagulants: mechanism of action, clinical effectiveness and optimal therapeutic range. Chest. 1998;114(5):445S-469S.
44. Research Committee of the British Thoracic Society. Optimum duration of anticoagulation for deep vein thrombosis and pulmonary embolism. Lancet. 1992;340:873-876.
45. Schulman S, Rhedin AS, Lindmarker P, et al. A comparison of six weeks with six months of oral anticoagulation therapy after a first episode of venous thromboembolism. N Engl J Med. 1995;332:1661-1665.
46. Levine MN, Hirsh J, Gent M, et al. Optimal duration of oral anticoagulant therapy: a randomized trial comparing four weeks with three months of warfarin in patients with proximal deep vein thrombosis. Thromb Haemost. 1995;74:606-611.
47. Miller RR, Lies JE, Carretta RF, et al. Prevention of lower extremity venous thrombosis by early mobilization. Ann Intern Med. 1976;84:700-703.
48. Wells P, Lensing A, Hirsh J. Graduated compression stockings in the prevention of postoperative venous thromboembolism: a metaanalysis. Arch Intern Med. 1994;154:67-72.
49. Clagett GP, Anderson FA, Heit J, et al. Prevention of venous thromboembolism. Chest. 1995;108(S):312S-334S.
50. Salzman E, McManama G, Shapiro A, et al. Effect of optimization of hemodynamics on fibrinolytic activity and antithrombotic efficacy of external pneumatic calf compression. Ann Surg. 1987;206:636-641.
51. Green D, Rossi E, Yao J, et al. Deep vein thrombosis in spinal cord injury: effect of prophylaxis with calf compression, aspirin, and dipyridamole. Paraplegia. 1982;20:227-234.
52. Merli G, Crabbe S, Doyle L, et al. Mechanical plus pharmacological prophylaxis for deep vein thrombosis in acute spinal cord injury. Paraplegia. 1992;30:558-562.
53. Wilson JT, Rogers FB, Wald SI, et al. Prophylactic vena cava filter insertion in patients with traumatic spinal cord injury: preliminary results. Neurosurg. 1994;35:234-239.
54. Khansarinia S, Dennis JW, Veldenz HC, et al. Prophylactic Greenfield filter placement in selected high-risk trauma patients. J Vasc Surg. 1995;22:231-236.
55. Rogers FB, Shackford SR, Ricci MA, et al. Routine prophylactic vena cava filter insertion in severely injured trauma patients decreased the incidence of pulmonary embolism. Am Coll Surg. 1995;180:641-647.
56. Green D. Venous thromboembolism. In: Green D, ed. Medical Management of Long-Term Disability. 2nd ed. Boston: ButterworthHeinemann; 1996:199-216.
57. Green D, Lee MY, Ito VY, et al. Fixed versus adjusted dose heparin in the prophylaxis of thromboembolism in spinal cord injury. JAMA. 1988;260:1255-1258.
58. Hirsh J, Raschke R, Warkentin TE, et al. Heparin: mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety. Chest. 1995;108(S):258S-275S.
59. Consortium for Spinal Cord Medicine. Prevention of Thromboembolism in Spinal Cord Injury. 2nd ed. Washington, DC: Paralyzed Veterans of America; 1999.
60. Green D, Hirsh J, Heit J, et al. Low molecular weight heparin: a critical analysis of clinical trials. Pharmacol Rev. 1994;46:89-109.
61. Green D, Lee MY, Lim AC. Prevention of thromboembolism after spinal cord injury using low molecular weight heparin. Ann Intern Med. 1990;113:571-574.
62. Green D, Chen D, Chmiel JS, et al. Prevention of thromboembolism in spinal cord injury: role of low molecular weight heparin. Arch Phys Med Rehabil. 1994;75:290-292.
63. Harris S, Chen D, Green D. Enoxaparin for thromboembolism prophylaxis in spinal injury. Am J Phys Med Rehabil. 1996;75:1-3.
64. Geerts WH,Jay RM, Code KI, et al. A comparison of low-dose heparin with low-molecularweight heparin as prophylaxis against venous thromboembolism after major trauma. N Engl J Med. 1996;335:701-707.