Serum pepsinogen levels in gastric cancer patients and their relationship with Helicobacter pylori infection: A prospective study

Gastric Cancer

Volumn 5, Issue 4, 2002, Pages 228-232

  So, Jimmy Bok Yan ^a   Yeoh, Khay Guan ^a   Moochala, Shabbir ^b   Chachlani, Naresh ^a   Ho, Jean ^c   Wong, Wai Keong ^c   Mack, Peter ^c   Goh, Peter M Y ^d  

^a NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^b Defense Medical Research Institute   (Singapore)

^c SINGAPORE GENERAL HOSPITAL   (Singapore)

^d UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Gastric atrophy; Gastric carcinoma; Gastrin; H. pylori; Pepsinogen

Indexed keywords

GASTRIN; PEPSINOGEN; PEPSINOGEN I; PEPSINOGEN II;

ADULT; AGED; ARTICLE; ATROPHY; CANCER DIAGNOSIS; CANCER PATIENT; CANCER SCREENING; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GASTRITIS; HELICOBACTER INFECTION; HISTOPATHOLOGY; HUMAN; INTESTINE METAPLASIA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; STOMACH CARCINOMA;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; FEMALE; GASTRINS; GASTRITIS, ATROPHIC; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED; PEPSINOGEN A; PEPSINOGEN C; PROSPECTIVE STUDIES; STOMACH NEOPLASMS;

EID: 0037512501     PISSN: 14363291     EISSN: None     Source Type: Journal    
DOI: 10.1007/s101200200039     Document Type: Article

References (24)

1. Ti TK. Pattern and surgical treatment of gastric cancer in Singapore. Br J Surg 1993;80:886-9.
2. Wanebo HJ, Kennedy BJ, Chmiel J, Steele G, Winchester D, Osteen R. Cancer of stomach. A patient care study by the American College of Surgeons. Ann Surg 1993;218:583-592.
3. Samloff IM, Varis K, Ihamaki T, Siurala M, Rotter JL. Relationships among serum pepsinogen I, serum pepsinogen II, and gastric mucosal histology - a study in relatives of patients with pernicious anemia. Gastroenterology 1982;83:204-9.
4. Miki K, Ichinose M, Shimizu, Huang SC, Oka H, Furihata C, et al. Serum pepsinogens as a screening test of extensive chronic gastritis. Gastroenterol Jpn 1987;22:133-141.
5. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process. Cancer Res 1992;52:6735-40
6. Fukao A, Hisamichi S, Ohsato N, Fujino N, Endo N, Masaharu I. Correlation between the prevalence of gastritis and gastric cancer in Japan. Cancer Causes Control 1993;4:17-20
7. Miki K, Ichinose M, Ishikawa K, Yahagi N, Matsushima M, Kakei N, et al. Clinical application of serum pepsinogen I and II levels for mass screening to detect gastric cancer. Jpn J Cancer Res 1993; 84:1086-90.
8. Kudoi A, Yoshihara M, Sumii K, Huruma K, Kajiyama G. Serum pepsinogen in screening for gastric cancer. J Gastroenterol 1990; 30:452-60.
9. Yoshihara M, Sumii K, Haruma K, Kiyohira K, Hattori N, Kitadai Y, et al. Correlation of ratio of serum pepsinogen I and II with prevalence of gastric cancer and adenoma in Japanese subjects. Am J Gastroenterol 1998;7:1090-6.
10. Kitahara F, Kobayashi K, Sato T, Kojima Y, Araki T, Fujino MA. Accuracy of screening for gastric cancer using serum pepsinogen concentrations. Gut 1999;44:693-7.
11. Schlemper RJ, van der Werf SDJ, Vandenbroucke JP, Birmond I, Lamers C. Seroepidemiology of gastritis in Japanese and Dutch working populations: evidence for the development of atrophic gastritis that is not related to Helicobacter pylori. Gut 1995;37: 199-204.
12. Ichinose M, Miki K, Furihata C, Kageyama T, Hayashi R, Niwa H, et al. Radioimmunoassay of serum group I and II pepsinogens in normal controls and patients with various disorders. Clin Chim Acta 1982;126:183-91.
13. Kang JY, Yeoh KG, Ho KY, Lim TP, Quak SH, Wee A, et al. Racial differences in Helicobacter pylori seroprevalence in Singapore: correlation with differences in peptic ulcer frequency. J Gastroenterol Hepatol 1982;12:655-99.
14. Hengals KJ. Das Menschliche pepsinogen-pepsin system. Stuttgart: Georg Thieme Verlag; 1986.
15. Westerveld BD, Pals G, Lamers CBHW, Defize J, Pronk JC, Frants RR. Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels. Cancer 1987;59:952-8.
16. Miki K, Ichinose M, Kawamura N, Matsushima T, Ahmad HB, Kimura M, et al. Serum pepsinogen levels to detect gastric cancer associated with chronic gastritis in Japanese subjects. Jpn J Cancer Res 1989;80:111-4.
17. Wee A, Kang KY, Teh M. Helicobactor pylori and gastric cancer: correlation with gastritis; intestinal metaplasia, and tumour histology. Gut 1992;33:1029-32.
18. Kato I, Tominaga S, Ito Y, Kobayashi S, Yoshii Y, Matsuura A, et al. Atrophic gastritis and gastric cancer risk: cross section analysis. Jpn J Cancer Res 1992;83:1041-6.
19. Kuipers EJ. Relationship between Helicobactor pylori, atrophic gastritis and gastric cancer. Aliment Pharmacol Ther 1998;12 (Suppl 1):25-36.
20. Asaka M, Kimura T, Kudo M, Takeda H, Mitani S, Miyazaki T, et al. Relationship of Helicobactorpylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology 1998;102: 760-6.
21. Webb PM, Hengels KJ, Moller H, Ninewell DG, Palli D, Elder JB, et al. The epidemiology of lower serum pepsinogen A levels and an international association with gastric cancer rates. Gastroenterology 1994;107:1335-44.
22. Zheng PY, Hua J, Yeoh KG, Ng HC, Ho B. Association of peptic ulcer with increased expression of Lewis antigens, but not cagA, iceA and vacA in Helicobactor pylori isolates in an Asian population. Gut 47:18-22, 2000
23. Huan J, Zheng PY, Yeoh KG, Ho B. The enigmatic prevalence of cagA positive Helicobacter pylori in Singapore. Microbios 2000; 102:113-20
24. Webb PM, Crabtree JE, Forman D. Gastric cancer, cytotoxin-associated gene A-positive Helicobacter pylori, and serum pepsinogens: an international study. Gastroenterology 1999;116: 269-76.