Investigation into the mechanisms of vagus nerve stimulation for the treatment of intractable epilepsy, using 99mTc-HMPAO SPET brain images

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 30, Issue 2, 2003, Pages 301-305

  Barnes, Anna ^a   Duncan, Roderick ^a   Chisholm, Jennifer A ^a   Lindsay, Kenneth ^a   Patterson, James ^a   Wyper, David ^a  

^a SOUTHERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Epilepsy; HMPAO; SPET; Vagus nerve stimulation

Indexed keywords

ANTICONVULSIVE AGENT; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M;

ADULT; AMYGDALOID NUCLEUS; ARTICLE; BRAIN MAPPING; BRAIN STEM; BRAIN TOMOGRAPHY; CINGULATE GYRUS; CLINICAL ARTICLE; COMPLEX PARTIAL SEIZURE; COUGHING; FEMALE; HIPPOCAMPUS; HUMAN; IMAGE ANALYSIS; IMAGING SYSTEM; INTRACTABLE EPILEPSY; LIMBIC SYSTEM; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THALAMUS; TREATMENT OUTCOME; VAGUS NERVE STIMULATION;

EID: 0037501292     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-002-1026-8     Document Type: Article

References (16)

1. DeGiorgio CM, Schachter SC, Handforth A, Salinsky M, Thompson J, Uthman B, Reed R, Collins S, Tecoma E, Morris GL, Vaughn B, Naritoku DK, Henry T, Labar D, Gilmartin R, Labiner D, Osorio I, Ristanovic R, Jones J, Murphy J, Ney G, Wheless J, Lewis P, Heck C. Prospective long-term study of vagus nerve stimulation for the treatment of refractory seizures. Epilepsia 2000; 41:1195-1200.
2. Zagon AK. Slow hyperpolarization in cortical neurons: a possible mechanism behind vagus nerve simulation therapy for refractory epilepsy? Epilepsia 2000; 41:1382-1389.
3. Henry TR. Functional imaging studies of epilepsy therapies. Adv Neurol 2000; 83:305-317.
4. Friston KJ, Holmes A, Poline JB, Price CJ, Frith CD. Detecting activations in PET and fMRI: levels of inference and power. Neuroimage 1996; 4:223-235.
5. Henry TR, Bakay RA, Votaw JR, Pennell PB, Epstein CM, Faber TL, Grafton ST, Hoffman JM. Brain blood flow alterations induced by therapeutic vagus nerve stimulation in partial epilepsy: I. Acute effects at high and low levels of stimulation. Epilepsia 1998; 39:983-990.
6. 2 PET activation study. J Nucl Med 2002; 43:S544.
7. Wieser HG. Mesial temporal lobe epilepsy versus amygdalar epilepsy: late seizure recurrence after initially successful amygdalotomy and regained seizure control following hippocampectomy. Epileptic Disord 2000; 2:141-152.
8. Preyett M, Duncan JS, Fish DR. Cerebral blood flow during absence seizures in humans. Epilepsia 1993; 25:8-21.
9. Barnes A, Dai D, Montaldi D, Patterson J, Wyper D. Image quality versus statistical power. Nucl Med Commun 1997; 18:1155-1160.
10. Holmes AP. Generalisability, random effects and population inference. Neuroimage 1998; 7:S754.
11. Garnett ES, Scheffel A, Firnau G, Upton AR. Regional cerebral blood flow in man manipulated by direct vagal stimulation. Pacing Clin Electrophysiol 1992; 15:1579-1580.
12. Ko D, S Grafton S, Apuzzo ML, Couldwell WT, Chen T, Day JD, Zelman V, Smith T, DeGiorgio CM. Vagus nerve stimulation activates central nervous system structures in epileptic patients during PET H2(15)O blood flow imaging. Neurosurgery 1996; 39:426-430.
13. Ring HA, Costa DC, Pottinger R, Dick JP, Koeze T, Sutcliffe J. A SPECT study of the effect of vagal nerve stimulation on thalamic activity in patients with epilepsy. Seizure 2000; 9: 380-384.
14. Vonck K, Van Laere K, D'Have M, Vandekerckhove T, O'Connor S, Brans B, Dierckx R, De Reuck J. Acute single photon emission computed tomographic study of vagus nerve stimulation in refractory epilepsy. Epilepsia 2001; 41:601-609.
15. Bohning DE, Lomarev MP, Denslow S, Nahas Z, Shastri A, George MS. Feasibility of vagus nerve stimulation-synchronized blood oxygenation level-dependent functional MRI. Invest Radiol 2001; 36:470-479.
16. Van Laere K, Vonck K, Boon P, Versijpt J, Dierckx R. Perfusion SPECT changes after acute and chronic vagus nerve stimulation in relation to prestimulus condition and long-term clinical efficacy. J Nucl Med 2002; 43:733-744.