The clinical use of aerosolized antibiotics

Clinical Pulmonary Medicine

Volumn 10, Issue 4, 2003, Pages 201-207

  Conrad, Douglas J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

Aerosolized antibiotics; Amphotericin; Colistin; Tobramycin

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPHOTERICIN B; ANTIBIOTIC AGENT; PENTAMIDINE; TOBRAMYCIN; ZANAMIVIR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AEROSOL; ANTIBIOTIC THERAPY; ASPERGILLOSIS; BRONCHITIS; CYSTIC FIBROSIS; DISEASE SEVERITY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; HUMAN; INFECTION RISK; INFLUENZA; LUNG FUNCTION; LUNG TRANSPLANTATION; NEBULIZER; PARTICLE SIZE; PATIENT COMPLIANCE; PNEUMOCYSTIS CARINII; PNEUMOCYSTOSIS; PSEUDOMONAS AERUGINOSA; RESPIRATORY TRACT INFECTION; REVIEW; RISK FACTOR; SYMPTOMATOLOGY; TRACHEOBRONCHIAL TREE; TRACHEOTOMY; TREATMENT PLANNING; TUBERCULOSIS;

EID: 0037492808     PISSN: 10680640     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.cpm.0000080903.11193.e9     Document Type: Review

References (30)

1. Hodson ME, Penketh ARL, Batern JC. Aerosol carbenicillin and gentamycin treatment of pseudomonas aeruginosa infection in patients with cystic fibrosis. Lancet. 1981;2:1137-1139.
2. Campbell PW, Saiman L. Use of aerosolized antibiotics in patients with cystic fibrosis. Chest. 1999;3:775-788.
3. Ramsey BW, Dorkin HL, Eisenberg JD, et al. Efficacy of aerosolized tobramycin in patients with cystic fibrosis. N Engl J Med. 1993;24:1740-1746.
4. Ramsey BW, Pepe MS, Quan JM, et al. Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group. N Engl J Med. 1999;1:23-30.
5. Ramsey B, Quan. JM, Otto KL, et al. Interim analysis of data from an open-label follow-on trial of inhaled tobramycin (PC-TNDS-004) in patients with Cystic Fibrosis. Pediatr Pulmonol. 1998;S17:320.
6. LiPuma JJ. Microbiological and immunologic considerations with aerosolized drug delivery. Chest. 2001;3(Suppl):118S-123S.
7. Bums JL, Van Dalfsen JM, Shawar RM, et al. Effect of chronic intermittent administration of inhaled tobramycin on respiratory microbial flora in patients with cystic fibrosis. J Infect Dis. 1999;5:1190-1196.
8. Jensen T, Pedersen SS, Garne S, et al. Colistin inhalation therapy in cystic fibrosis patients with chronic pseudomonas aeruginosa lung infection. J Antimicrob Chemother. 1987;6:831-838.
9. Schaad UB, Wedgwood-Krucko J, Suter S, et al. Efficacy of inhaled amikacin as adjunct to intravenous combination therapy (ceftazidime and amikacin) in cystic fibrosis. J Pediatr. 1987;4:599-605.
10. Frederiksen B, Koch C, Hoiby N. Antibiotic treatment of initial colonization with pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fibrosis. Pediatr Pulmonol. 1997;5:330-335.
11. Bauldoff GS, Nunley DR, Manzetti JD, et al. Use of aerosolized colistin sodium in cystic fibrosis patients awaiting lung transplantation. Transplantation. 1997;5:748-752.
12. Orriols R, Roig J, Ferrer J, et al. Inhaled antibiotic therapy in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection by pseudomonas aeruginosa. Respir Med. 1999;7:476-480.
13. Barker AF, Couch L, Fiel SB, et al. Tobramycin solution for inhalation reduces sputum pseudomonas aeruginosa density in bronchiectasis. Am J Respir Crit Care Med. 2000;162:481-485.
14. Klastersky J, Huysmans E, Weerts D, et al. Endotracheally administered gentamicin for the prevention of infections of the respiratory tract in patients with tracheostomy: a double-blind study. Chest. 1974;6:650-654.
15. Klastersky J, Carpentier-Meunier F, Kahan-Coppens L., et al. Endotracheally administered anobiotics for gram-negative bronchopneumonia. Chest. 1979;5:586-591.
16. Brown RB, Kruse JA, Counts GW, et al. Double-blind study of endotracheal tobramycin in the treatment of gram-negative bacterial pneumonia. The Endotracheal Tobramycin Study Group. Antimicrob Agents Chemother. 1990;2:269-272.
17. Palmer LB, Smaldone GC, Simon SR, et al. Aerosolized antibiotics in mechanically ventilated patients: delivery and response. Crit Care Med. 1998;1:31-39.
18. Sacks LV, Pendle S, Orlovic D, et al. Adjunctive salvage therapy with inhaled aminoglycosides for patients with persistent smear-positive pulmonary tuberculosis. Clin Infect Dis. 2001;1:44-49.
19. Iseman MD. Some healthy skepticism about inhaled therapy for tuberculosis. Clin Infect Dis. 2001;2:266-267.
20. Palmer SM, Drew RH, Whitehouse JD, et al. Safety of aerosolized amphotericin B lipid complex in lung transplant recipients. Transplantation. 2001;3:545-548.
21. Calvo V, Borro JM, Morales P, et al. Antifungal prophylaxis during the early postoperative period of lung transplantation. Valencia Lung Transplant Group. Chest. 1999;5:1301-1304.
22. Schwartz S, Behre G, Heinemann V, et al. Aerosolized amphotericin B inhalations as prophylaxis of invasive aspergillus infections during prolonged neutropenia: results of a prospective randomized multicenter trial. Blood. 1999;11:3654-3661.
23. Leoung GS, Feigal DW, Montgomery AB, et al. Aerosolized pentamidine for prophylaxis against pneumocystis carinii pneumonia. The San Francisco community prophylaxis trial. N Engl J Med. 1990;12:769-775.
24. Montgomery AB, Debs RJ, Luce JM, et al. Aerosolized pentamidine as second line therapy in patients with AIDS and pneumocystis carinii pneumonia. Chest. 1989;4:747-750.
25. Bozzette SA, Finkelstein DM, Spector SA, et al. A randomized trial of three antipneumocystis agents in patients with advanced human immunodeficiency virus infection. NIAID AIDS Clinical Trials Group. N Engl J Med. 1995;11:693-699.
26. Hardy WD, Feinberg J, Finkelstein DM, et al. A controlled trial of trimethoprim-sulfamethoxazole or aerosolized pentamidine for secondary prophylaxis of pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. AIDS Clinical Trials Group Protocol 021. N Engl J Med. 1992;26:1842-1848.
27. Smith DW, Frankel LR, Mathers LH, et al. A controlled trial of aerosolized ribavirin in infants receiving mechanical ventilation for severe respiratory syncytial virus infection. N Engl J Med. 1991;1:24-29.
28. Guerguerian AM, Gauthier M, Lebel MH, et al. Ribavirin in ventilated respiratory syncytial virus bronchiolitis. A randomized, placebo-controlled trial. Am J Respir Crit Care Med. 1999;3:829-834.
29. The MIST (Management of Influenza in the Southern Hemisphere Trialists) Study Group. Randomised trial of efficacy and safety of inhaled zanamivir in treatment of influenza A and B virus infections. Lancet. 1998;9144:1877-1881.
30. Lalezari J, Campion K, Keene O, et al. Zanamivir for the treatment of influenza A and B infection in high-risk patients: a pooled analysis of randomized controlled trials. Arch Intern Med. 2001;2:212-217.