The calcium channel ligand FPL 64176 enhances L-type but inhibits N-type neuronal calcium currents

Neuropharmacology

Volumn 45, Issue 2, 2003, Pages 281-292

  Liu, Liwang ^a   Gonzalez, Pamela K ^a,b   Barrett, Curtis F ^a,c   Rittenhouse, Ann R ^a  

^a UMASS MEMORIAL MEDICAL CENTER   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

(+) 202 791; Benzoyl pyrrole; FPL 64176; L type Ca2+ channels; N type Ca2+ channels; PC12 cells; Superior cervical ganglion

Indexed keywords

4 (2 BENZYLBENZOYL) 2,5 DIMETHYL 1H PYRROLE 3 CARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL STIMULATING AGENT; DIHYDROPYRIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CELL ADHESION; CHANNEL GATING; CONCENTRATION RESPONSE; CONDUCTANCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; EMBRYO; HUMAN; HUMAN CELL; LATENT PERIOD; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; SYMPATHETIC NERVE CELL; TIME;

EID: 0037492580     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(03)00153-9     Document Type: Article

References (44)

1. 2+ channel triggers transmitter release in PC12 cells. FEBS Letters. 342:1994;209-213.
2. Barrett C.F., Rittenhouse A.R. Modulation of N-type calcium channel activity by G-proteins and protein kinase C. Journal of General Physiology. 115:2000;277-286.
3. Barrett C.F., Liu L., Rittenhouse A.R. Arachidonic acid reversibly enhances N-type calcium current at an extracellular site. American Journal of Physiology - Cell Physiology. 280:2001;C1306-C1318.
4. Bell D.C., Butcher A.J., Berrow N.S., Page K.M., Brust P.F., Nesterova A., Stauderman K.A., Seabrook G.R., Nurnberg B., Dolphin A.C. Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha (1D), Ca(V)1.3) voltage-dependent calcium channels. Journal of Neurophysiology. 85:(2):2001;816-827.
5. 2+ channels in mammalian central neurons. Trends in Neuroscience. 18:1995;89-98.
6. 2+ channels in cardiac myocytes. Naunyn-Schmiedebergs Archives of Pharmacology. 361:2000;465-476.
7. Gonzalez P.K., Rittenhouse A.R. Biophysical comparison of two L-type calcium channel agonists. Journal of General Physiology. 112:1998;46A.
8. Grabner M., Wang Z., Hering S., Striessnig J., Glossmann H. Transfer of 1,4-dihydropyridine sensitivity from the L-type to class A (B1) calcium channels. Neuron. 16:1996;207-218.
9. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth E.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patched. Pfluegers Archiv. 391:1981;85-100.
10. Hess P., Lansman J.B., Tsien R.W. Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature. 311:1984;538-544.
11. Jeong S.W., Wurster R.D. Calcium channel currents in acutely dissociated intracardiac neurons from adult rats. Journal of Neurophysiology. 77:1997a;1769-1778.
12. 2+ channels in rat intracardiac neurons via a PTX- and voltage-sensitive pathway. Journal of Neurophysiology. 78:1997b;1476-1490.
13. Jinnah H.A., Sepkuty J.P., Ho T., Yitta S., Drew T., Rothstein J.D., Hess E.J. Calcium channel agonists and dystonia in mouse. Movement Disorders. 15:2000;542-551.
14. Kass R.S. Voltage-dependent modulation of cardiac calcium channel current by optical isomers of Bay K8644: implications for channel gating. Circulation Research. 61 (Suppl.):1987;I1-I5.
15. Kokubun S., Reuter H. Dihydropyridine derivatives prolong the open state of Ca channels in cultured cardiac cells. Proceedings of the National Academy of Sciences of the United States of America. 81:1984;4824-4827.
16. 3 cells. Molecular Pharmacology. 42:1992;666-670.
17. 2+ channels. Naunyn-Schmiedebergs Archives of Pharmacology. 360:1999;122-128.
18. Lacerda A.E., Brown A.M. Nonmodal gating of cardiac calcium channels as revealed by dihydropyridines. Journal of General Physiology. 93:1989;1243-1273.
19. 2+ current in sympathetic neurons. Biophysical Journal. 66:1994;A422.
20. Lin Z., Harris C., Lipscombe D. The molecular identity of Ca channel alpha 1-subunits expressed in rat sympathetic neurons. Journal of Molecular Neuroscience. 7:1996;257-267.
21. 2+ channel in rat sympathetic ganglia and brain. Neuron. 18:1997;153-166.
22. 1B generates functionally distinct N-type calcium channels in central and peripheral neurons. Journal of Neuroscience. 19:1999;5322-5331.
23. 2+ channels in PC12 cells. Journal of Neuroscience. 16:1996;7557-7565.
24. Liu L., Rittenhouse A.R. Effects of arachidonic acid on unitary calcium currents in rat sympathetic neurons. Journal of Physiology (London). 525:(Pt 2):2000;391-404.
25. Liu L., Rittenhouse A.R. The arachidonic acid signaling pathway mediates muscarinic inhibition of L-type calcium currents in sympathetic neurons. Society for Neuroscience Abstracts. 24:1998;1021.
26. Liu L., Barrett C.F., Rittenhouse A.R. Arachidonic acid both inhibits and enhances whole-cell calcium currents in rat sympathetic neurons. American Journal of Physiology - Cell Physiology. 280:2001;C1293-C1305.
27. + channels by nerve growth factor. Proceedings of the National Academy of Sciences of the United States of America. 85:1988;924-928.
28. Nowycky M.C., Fox A.P., Tsien R.W. Long-opening mode of gating of neuronal calcium channels and its promotion by the dihydropyridine calcium agonist Bay K 8644. Proceedings of the National Academy of Sciences of the United States of America. 82:1985;2178-2182.
29. N'Gouemo P., Rittenhouse A.R. Biophysical and pharmacological characterization of voltage-sensitive calcium currents in neonatal rat inferior colliculus neurons. Neuroscience. 96:2000;753-765.
30. Ochi R., Hino N., Niimi Y. Prolongation of calcium channel open time by the dihydropyridine derivative BAY K 8664 in cardiac myocytes. Proceedings of the Japanese Academy B Physiological and Biological Sciences. 60:1984;153-158.
31. Plummer M.R., Logothetis D.E., Hess P. Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons. Neuron. 2:1989;1453-1463.
32. Rampe D., Lacerda A.E. A new site for the activation of cardiac calcium channels defined by the nondihydropyridine FPL 64176. Journal of Pharmacology and Experimental Therapeutics. 259:1991;982-987.
33. 2+ channel currents in rat cerebellar granule neurons. Journal of Neuroscience. 15:1995;2995-3012.
34. 1 subunits. Neuron. 11:1993;291-303.
35. Schjött J.M., Plummer M.R. Sustained activation of hippocampal Lp-type voltage-gated calcium channels by tetanic stimulation. Journal of Neuroscience. 20:2001;4786-4797.
36. Scott R.H., Dolphin A.C. Activation of a G protein promotes agonist responses to calcium channel ligands. Nature. 330:1987;760-762.
37. Scott R.H., Dolphin A.C. The agonist effect of Bay K 8644 on neuronal calcium channel currents is promoted by G-protein activation. Neuroscience Letters. 89:1988;170-175.
38. (2+) channels by using knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 96:1999;10899-10904.
39. 2+ channels in rat phaeochromocytoma cell lines. Journal of Physiology. 426:1990;95-116.
40. White M.G., Crumling M.A., Meriney S.D. Developmental changes in calcium current pharmacology and somatostatin inhibition in chick parasympathetic neurons. Journal of Neuroscience. 17:1997;6302-6313.
41. Williams J.S., Grupp I.L., Grupp G., Vaghy P.L., Dumont L., Schwartz A., Yatani A., Hamilton S., Brown A.M. Profile of the oppositely acting enantiomers of the dihydropyridine 202-791 in cardiac preparations: receptor binding electrophysiological, and pharmacological studies. Biochemical and Biophysical Research Communications. 131:1985;13-21.
42. Xu W., Lipscombe D. Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines. Journal of Neuroscience. 21:(16):2001;5944-5951.
43. 2+ channel agonists. Journal of Biological Chemistry. 275:2000;41504-41511.
44. 2+ channel activator, in cardiac and vascular preparations. Molecular Pharmacology. 40:1991;734-741.