Kidney structural and ultrastructural pathological changes induced by uracoan rattlesnake (Crotalus vegrandis Klauber 1941) venom

Journal of Submicroscopic Cytology and Pathology

Volumn 34, Issue 4, 2002, Pages 447-459

  Giron M ^a   Pinto, A ^a   Finol, H J ^b   Aguilar, I ^a   Rodriguez Acosta A ^a,c  

^a UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^b UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^c NONE   (Venezuela)

Author keywords

Acute renal insufficiency; Crotalus vegrandis; Myolysis; Phospholipase; Proteases

Indexed keywords

COLLAGEN FIBER; MYELIN; SNAKE VENOM;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGY; BASEMENT MEMBRANE; BLOOD VESSEL INJURY; CAPILLARY ENDOTHELIUM; CELL DENSITY; CELL FRACTIONATION; CELL STRUCTURE; CELL VACUOLE; CONTROLLED STUDY; DENSE BODY; EDEMA; ELECTRON MICROSCOPY; EXTRACELLULAR MATRIX; FENESTRATION; GLOMERULUS CAPILLARY; INJECTION; INTERDIGITATING CELL; INTERSTITIAL FLUID; KIDNEY PARENCHYMA; KIDNEY STRUCTURE; KIDNEY TUBULE EPITHELIUM; MITOCHONDRION; MOUSE; NONHUMAN; OBSERVATION; PODOCYTE; SNAKE; ULTRASTRUCTURE; ANIMAL; CAPILLARY; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG EFFECT; GLOMERULUS; INTRAPERITONEAL DRUG ADMINISTRATION; ISOLATION AND PURIFICATION; KIDNEY; KIDNEY TUBULE; LD 50; MALE; MOUSE STRAIN; PATHOLOGY; RAT; SPRAGUE DAWLEY RAT; VASCULARIZATION;

ANIMALIA; CROTALUS; CROTALUS VEGRANDIS; GLOMERULUS; SERPENTES;

ANIMALS; CAPILLARIES; CROTALID VENOMS; CROTALUS; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; INJECTIONS, INTRAPERITONEAL; KIDNEY; KIDNEY GLOMERULUS; KIDNEY TUBULES; LETHAL DOSE 50; MALE; MICE; MICE, INBRED STRAINS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0037492378     PISSN: 11229497     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. AGUILAR I., GIRÓN M.E. and RODRIGUEZ-ACOSTA A., 2001. Purification and characterisation of a haemorrhagic fraction from the venom of the uracoan rattlesnake Crotalus vegrandis. Biochim. Biophys. Acta, 36450, 1-9.
2. ANDERSON S.G. and OWNBY C.L., 1997. Systemic hemorrhage induced by proteinase H from Crotalus adamanteus (Eastern Diamond back rattlesnake) venom. Toxicon, 35, 1301-1313.
3. ANONYMOUS, 1985. 'Principles of Laboratory Animal Care'. National Institute of Health of United States, Maryland, USA, publication 85-23.
4. BJARNASON J.B. and FOX J.W., 1988-1989. Hemorrhagic toxins from snake venoms. J. Toxicol.-Toxin Rev., 7, 121-209.
5. BLUM H., BEIER H. and GROSS H.J., 1997. Improved silver staining of plant proteins. RNA and DNA in polyacrylamide gels. Electrophoresis, 8, 93-99.
6. BURDMANN E.A., WORONIK V., PRADO E.B.A., ABDULKADER R.G., SALDAHA L.B., BARRETO O.C. and MARCONDES M., 1993. Snakebite-induced acute renal failure: an experimental model. Am. J. Trop. Med. Hyg., 48, 82-88.
7. CATTELL V. and BRADFIELD J.W.B., 1977. Focal mesangial proliferative glomerulonephritis in the rat caused by Habu snake venom. Am. J. Pathol., 87, 511-524.
8. CHUGH K., 1989. Snakebite induced acute renal failure in India. Kidney Int., 35, 891-907.
9. DA SILVA O.A., LÓPEZ M. and GODOY P., 1979. Intensive care unit treatment of acute renal failure following snake bite. Am. J. Trop. Med. Hyg., 28, 401-407.
10. EGGERTSEN G., FOLMAN J., SVALANDER C. and SJOQUIST J., 1979. The effect of Habu snake (Trimeresurus flavoviridis) venom on the kidneys in mice. Toxicon, 7 (Suppl. 1), 39.
11. KAISER I.I. and AIRD S.D., 1987. A crotoxin homologue from venom of the Uracoan rattlesnake (Crotalus vegrandis). Toxicon, 25, 1113-1118.
12. KINI R.M. and EVANS H.J., 1987. Structure-function relationships of phospholipases. The anticoagulant region of phospholipases A2. J. Biol. Chem., 262, 14402-14407.
13. KONDO H., KONDO S., IKEZAWA H., MURATA R. and OHSAKA A., 1960. Studies on the quantitative method for determination of hemorrhagic activity of Habu snake venom. Jpn. J. Med. Sci. Biol., 13, 43-49.
14. OGURA M., URBINA C., GONZÁLEZ M., RODRÍGUEZ P. and FINOL H.J., 1997. Introducción a la Microscopía Electrónica. Centro de Microscopía Electrónica, Facultad de Ciencias, Universidad Central de Venezuela, Caracas, Venezuela.
15. MARKLAND F.S., 1998. Snake venom and the hemostatic system. Review article. Toxicon, 36, 1749-1800.
16. MASON R.G. and BALIS J.U., 1980. Pathology of the endothelium. In: 'Pathobiology of Cell Membranes'. Trump B.F. and Arstila A.U. eds., Academic Press, New York.
17. MCKAY D.G., MOROZ C., DE VRIES A., CSAVOSSY I. and CRUSE V., 1970. The action of hemorrhagin and phospholipase derived from Vipera palestinae venom on microcirculation. Lab. Invest., 22, 387-399.
18. MOREIRA L., GUTIÉRREZ J.M., BORROW G. and OVADÍA M., 1992. Ultrastructural alterations in mouse capillary blood vessels after experimental injection of venom from Bothrops asper (Terciopelo). Exp. Mol. Pathol., 57, 124-133.
19. NAHAS L., KAMIGUTI A.S. and BARROS M.A.R., 1979. Thrombin-like and factor X activator components of Bothrops snake venom. Thromb. Haemost., 4, 314-328.
20. OWNBY C. and GEREN C.R., 1987. Pathogenesis of hemorrhage induced by hemorrhagic proteinase IV from timber rattlesnake (Crotalus horridus horridus) venom. Toxicon, 25, 517-526.
21. PETRICEVICH V.L., TEIXEIRA C.F.P., TAMBOURGI D.V. and GUTIERREZ J.M., 2000. Increments in serum cytokines and nitric oxide levels in mice injected with Bothrops asper and Bothrops jararaca snake venoms. Toxicon, 38, 1253-1266.
22. PIFANO F. and RODRÍGUEZ-ACOSTA A., 1989. Accidentes producidos por serpientes ponzoñosas Venezolanas. Facultad de Medicina, Cátedra de Medicina Tropical, Universidad Central de Venezuela, Caracas, Venezuela.
23. PIFANO F. and RODRÍGUEZ-ACOSTA A., 1995. Sobre el emponzoñamiento por la cascabel de Uracoa (Crotalus vegrandis. Klauber 1941) serpiente neotropical. Rev. Fac. Med., 18, 194-196.
24. ROBBINS S., ANGELL M. and KUMAR V., 1985. Patología Humana, Editorial Interamericana, México.
25. RODRÍGUEZ-ACOSTA A., MONDOLFI A., ORIHUELA R. and AGUILAR A., 1995 ¿Qué hacer frente a un accidente ofídico?. Venediciones. C.A. Caracas-Venezuela.
26. RODRÍGUEZ-ACOSTA A., AGUILAR I. and GIRÓN M.E., 1996. Biochemical and hematological effects of Uracoan rattlesnake (Crotalus vegrandis) venom on hamster (Cricetus auratus). J. Nat. Toxins, 5, 401-407.
27. RODRÍGUEZ-ACOSTA A., AGUILAR I., GIRÓN M.E. and RODRÍGUEZ-PULIDO V., 1998. Haemorrhagic activity of neotropical rattlesnake (Crotalus vegrandis Klauber, 1941). Nat. Toxins, 6, 15-18.
28. SPEARMAN-KARBER R., 1978. Alternative Methods of Analysis for Quantal Responses. In: 'Statistical Method in Biological Assay'. Finney D.J., Griffin Ch. eds., London.
29. SITPRIJA V. and BOONPUCNAVIG V., 1977. The kidney in tropical snake bite. Clin. Nephrol., 8, 377-383.
30. SITPRIJA V. and CHAIYABUTR N., 1999. Nephrotoxicity in snake envenomation. J. Nat. Toxins, 8, 271-277.
31. TRUMP B.F. and BEREZESKY I.K., 1992. Cellular and molecular basis of toxic cell injury. In: 'Cardiovascular Toxicology'. Acosta D. Jr. ed., Raven Press Ltd., New York.
32. WHO, 1995. Poisonous animal bites and stings. WHO Weekly Epidemiol. Rec., 70, 315-316.