메뉴 건너뛰기




Volumn 25, Issue 5, 2003, Pages 377-381

Pharmacokinetics of diphenhydramine in healthy volunteers with a dimenhydrinate 25 mg chewing gum formulation

Author keywords

Chewing gum formulation; Dimenhydrinate; Diphenhydramine; Pharmacokinetics

Indexed keywords

DIMENHYDRINATE; DIPHENHYDRAMINE;

EID: 0037480819     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2003.25.5.769660     Document Type: Article
Times cited : (19)

References (22)
  • 1
    • 0003092787 scopus 로고    scopus 로고
    • Histamine, Bradykinin and their antagonists
    • Hardman, J.G., Limbird, L.E., Molinoff, P.B., Ruddon, R.W., Gilman, A.G. (Eds.). McGraw-Hill: New York
    • Babe, K.S., Seralin, W.E. Histamine, Bradykinin and their antagonists. In: The Pharmacological Basis of Therapeutics, 9th ed. Hardman, J.G., Limbird, L.E., Molinoff, P.B., Ruddon, R.W., Gilman, A.G. (Eds.). McGraw-Hill: New York 1996, 581-600.
    • (1996) The Pharmacological Basis of Therapeutics, 9th Ed. , pp. 581-600
    • Babe, K.S.1    Seralin, W.E.2
  • 2
    • 0015383241 scopus 로고
    • Meclizine and placebo in treating vertigo of vestibular origin. Relative efficacy in a double-blind study
    • Cohen, B., DeJong, J.M. Meclizine and placebo in treating vertigo of vestibular origin. Relative efficacy in a double-blind study. Arch Neurol 1972, 27: 129-35.
    • (1972) Arch Neurol , vol.27 , pp. 129-135
    • Cohen, B.1    DeJong, J.M.2
  • 4
    • 0025183037 scopus 로고
    • Diphenhydramine kinetics following intravenous, oral, and sublingual dimenhydrinate administration
    • Scavone, J.M., Luna, B.G., Harmatz, J.S., von Moltke, L., Greenblatt, D.J. Diphenhydramine kinetics following intravenous, oral, and sublingual dimenhydrinate administration. Biopharm Drug Dispos 1990, 11: 185-9.
    • (1990) Biopharm Drug Dispos , vol.11 , pp. 185-189
    • Scavone, J.M.1    Luna, B.G.2    Harmatz, J.S.3    Von Moltke, L.4    Greenblatt, D.J.5
  • 5
    • 0031950428 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of diphenhydramine 25 mg in young and elderly volunteers
    • Scavone, J.M., Greenblatt, D.J., Harmatz, J.S., Engelhardt, N., Shader, R.I. Pharmacokinetics and pharmacodynamics of diphenhydramine 25 mg in young and elderly volunteers. Clin Pharmacol 1998, 38: 603-9.
    • (1998) Clin Pharmacol , vol.38 , pp. 603-609
    • Scavone, J.M.1    Greenblatt, D.J.2    Harmatz, J.S.3    Engelhardt, N.4    Shader, R.I.5
  • 6
    • 0031449570 scopus 로고    scopus 로고
    • Therapeutic and toxic blood concentrations of more than 500 drugs
    • Schulz, M., Schmoldt, A. Therapeutic and toxic blood concentrations of more than 500 drugs. Pharmazie 1997, 52: 895-911.
    • (1997) Pharmazie , vol.52 , pp. 895-911
    • Schulz, M.1    Schmoldt, A.2
  • 7
    • 0018136653 scopus 로고
    • Correlation between plasma diphenhydramine level and sedative and antihistamine effects
    • Carruthers, S.G., Shoeman, D.W., Hignite, C.E., Azarnoff, D.L. Correlation between plasma diphenhydramine level and sedative and antihistamine effects. Clin Pharmacol Ther 1978, 23: 375-82.
    • (1978) Clin Pharmacol Ther , vol.23 , pp. 375-382
    • Carruthers, S.G.1    Shoeman, D.W.2    Hignite, C.E.3    Azarnoff, D.L.4
  • 8
    • 0022919280 scopus 로고
    • Asynchronies of diphenhydramine plasmo-performance relationships
    • Licko, V., Thompson, T., Barnett, G. Asynchronies of diphenhydramine plasmo-performance relationships. Pharmacol Biochem Behav 1986, 25: 365-70.
    • (1986) Pharmacol Biochem Behav , vol.25 , pp. 365-370
    • Licko, V.1    Thompson, T.2    Barnett, G.3
  • 9
    • 0024558796 scopus 로고
    • The pharmacodynamics of diphenhydramine-induced drowsiness and changes in mental perfomance
    • Gengo, F., Gabos, C., Miller, J.K. The pharmacodynamics of diphenhydramine-induced drowsiness and changes in mental perfomance. Clin Pharmacol Ther 1989, 45: 15-21.
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 15-21
    • Gengo, F.1    Gabos, C.2    Miller, J.K.3
  • 10
    • 0020572602 scopus 로고
    • Diphenhydramine determination in human plasma by gas-liquid chromatography using nitrogen-phosphorus detection. Application to single low-dose pharmacokinetic studies
    • Abernethy, D.R., Greenblatt, D.J. Diphenhydramine determination in human plasma by gas-liquid chromatography using nitrogen-phosphorus detection. Application to single low-dose pharmacokinetic studies. J Pharm Sci 1983, 72: 941-3.
    • (1983) J Pharm Sci , vol.72 , pp. 941-943
    • Abernethy, D.R.1    Greenblatt, D.J.2
  • 11
    • 0022492853 scopus 로고
    • Isothermal gas chromatographic determination of nanogram amounts of chlorimipramine, chlorpromazine and their N-desmethyl metabolites in plasma using nitrogen-selective detection
    • Ninci, R., Giovannini, M.G., Della Corte, L., Sgaragli, G.P. Isothermal gas chromatographic determination of nanogram amounts of chlorimipramine, chlorpromazine and their N-desmethyl metabolites in plasma using nitrogen-selective detection. J Chromatogr 1986, 381: 315-22.
    • (1986) J Chromatogr , vol.381 , pp. 315-322
    • Ninci, R.1    Giovannini, M.G.2    Della Corte, L.3    Sgaragli, G.P.4
  • 12
    • 0017175659 scopus 로고
    • GLC determination of methotrimeprazine and its sulfoxide in plasma
    • Dahl, S.G., Jacobsen, S. GLC determination of methotrimeprazine and its sulfoxide in plasma. J Pharm Sci 1976, 65: 1329-33.
    • (1976) J Pharm Sci , vol.65 , pp. 1329-1333
    • Dahl, S.G.1    Jacobsen, S.2
  • 13
    • 0022897897 scopus 로고
    • PKALC A BASIC interactive computer program for statistical and pharmacokinetic analysis of data
    • Shumaker, R.C. PKALC: A BASIC interactive computer program for statistical and pharmacokinetic analysis of data. Drug Metab Rev 1986, 17: 331-48.
    • (1986) Drug Metab Rev , vol.17 , pp. 331-348
    • Shumaker, R.C.1
  • 15
    • 0021735934 scopus 로고
    • A possible solution to the choice of weights problem in analysis of individual pharmacokinetic data
    • Peck, C.C., Beal, S.L., Sheiner, L.B., Nichols, A.I. A possible solution to the choice of weights problem in analysis of individual pharmacokinetic data. J Pharmacokinet Biopharm 1984, 12: 545-58.
    • (1984) J Pharmacokinet Biopharm , vol.12 , pp. 545-558
    • Peck, C.C.1    Beal, S.L.2    Sheiner, L.B.3    Nichols, A.I.4
  • 17
    • 0022535010 scopus 로고
    • Pharmacokinetics of diphenhydramine and a demethylated metabolite following intravenous and oral administration
    • Blyden, G.T., Greenblatt, D.J., Scavone, J.M., Shader, R.I. Pharmacokinetics of diphenhydramine and a demethylated metabolite following intravenous and oral administration. J Clin Pharmacol 1986, 26: 529-33.
    • (1986) J Clin Pharmacol , vol.26 , pp. 529-533
    • Blyden, G.T.1    Greenblatt, D.J.2    Scavone, J.M.3    Shader, R.I.4
  • 18
    • 0036076969 scopus 로고    scopus 로고
    • A randomized, placebo-controlled study comparing two formulations of dimenhydrinate with respect to efficacy in motion sickness and sedation
    • Seibel, K., Schaffler, K., Reitmeir, P. A randomized, placebo-controlled study comparing two formulations of dimenhydrinate with respect to efficacy in motion sickness and sedation. Arzneimittelforschung 2002, 52: 529-36.
    • (2002) Arzneimittelforschung , vol.52 , pp. 529-536
    • Seibel, K.1    Schaffler, K.2    Reitmeir, P.3
  • 19
    • 0021018265 scopus 로고
    • Serum levels of dimenhydrinate. Determination by HPLC wilh UV detection after intake of dimenhydrinate in a coated chewing gum dragee
    • Skofitsch, G., Lembeck, F. Serum levels of dimenhydrinate. Determination by HPLC wilh UV detection after intake of dimenhydrinate in a coated chewing gum dragee. Arzneimittelforschung 1983, 33: 1674-6.
    • (1983) Arzneimittelforschung , vol.33 , pp. 1674-1676
    • Skofitsch, G.1    Lembeck, F.2
  • 20
    • 0025353290 scopus 로고
    • Diphenhydramine: Pharmacokinetics and pharmacodynamics in elderly adults, young adults, and children
    • Simons, K.J., Watson, W.T., Martin, T.J., Chen, X.Y., Simons, F.E. Diphenhydramine: Pharmacokinetics and pharmacodynamics in elderly adults, young adults, and children. J Clin Pharmacol 1990, 30: 665-71.
    • (1990) J Clin Pharmacol , vol.30 , pp. 665-671
    • Simons, K.J.1    Watson, W.T.2    Martin, T.J.3    Chen, X.Y.4    Simons, F.E.5
  • 21
    • 0025572277 scopus 로고
    • Relative bioavailability of (±)-verapamil hydroclorid administered in tablets and chewing gum
    • Cristrupp, L.L., Bonde, J., Rasmussen, S.N., Rassing, M.R. Relative bioavailability of (±)-verapamil hydroclorid administered in tablets and chewing gum. Acta Pharm Nord 1990, 2: 371-6.
    • (1990) Acta Pharm Nord , vol.2 , pp. 371-376
    • Cristrupp, L.L.1    Bonde, J.2    Rasmussen, S.N.3    Rassing, M.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.