Gene expression patterns as potential molecular biomarkers for malignant transformation in human keratinocytes treated with MNNG, arsenic, or a metal mixture

Toxicological Sciences

Volumn 74, Issue 1, 2003, Pages 32-42

  Bae, Dong Soon ^a   Handa, Robert J ^b   Yang, Raymond S H ^b   Campain, Julie A ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b Department of Environmental Health   (United States)

Author keywords

Arsenic; cDNA microarray; Gene expression; Human keratinocytes; Metal mixture; Real time RT PCR; RHEK 1 cells

Indexed keywords

ARSENIC; BETA4 INTEGRIN; BIOLOGICAL MARKER; BONE MORPHOGENETIC PROTEIN 4; CADMIUM; CHROMIUM; LAMININ BINDING PROTEIN; LEAD; MACROPHAGE INFLAMMATORY PROTEIN 1; METALLOTHIONEIN; METHYLNITRONITROSOGUANIDINE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MOLECULAR MARKER; TUMOR SUPPRESSOR PROTEIN; ULINASTATIN; VIMENTIN;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA MICROARRAY; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; KERATINOCYTE; MALIGNANT TRANSFORMATION; NUCLEOTIDE SEQUENCE; QUALITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ARSENATES; BILE; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DITHIOTHREITOL; ENZYME INHIBITORS; ERYTHROCYTES; HUMANS; INOSINE; MALE; OXIDATION-REDUCTION; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRIMIDINONES; PYRROLES; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, ATOMIC; SULFHYDRYL REAGENTS;

EID: 0037480243     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg124     Document Type: Article

References (39)

1. Achanzar, W. E., Brambila, E. M., Diwan, B. A., Webber, M. M., and Waalkes, M. P. (2002). Inorganic arsenite-induced malignant transformation of human prostate epithelial cells. J. Natl. Cancer Inst. 94, 1888-1891.
2. Bae, D. S., Gennings, C., Carter, W. H., Jr., Yang, R. S. H., and Campain, J. A. (2001). Toxicological interactions among arsenic, cadmium, chromium, and lead in human keratinocytes. Toxicol. Sci. 63, 132-142.
3. Bae, D. S., Hanneman, W. H., Yang, R. S. H., and Campain, J. A. (2002). Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in human keratinocytes: Application of cDNA microarray technology. Environ. Health Perspect. 110(Suppl. 6), 931-941.
4. Bootcov, M. R., Bauskin, A. R., Valenzuela, S. M., Moore, A. G., Bansal, M., He, X. Y., Zhang, H. P., Donnellan, M., Mahler, S., Pryor, K., et al. (1997). MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc. Natl. Acad. Sci. U.S.A. 94, 11514-11519.
5. Chen, C.-J., Chuang, Y.-C., Lin, T.-M., and Wu, H.-Y. (1985). Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: High-arsenic artesian well water and cancer. Cancer Res. 45, 5895-5899.
6. Chiariello, M., Marinissen, M. J., and Gutkind, J. S. (2000). Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation. Mol. Cell Biol. 20, 1747-1758.
7. Dandachi, N., Hauser-Kronberger, C., More, E., Wiesener, B., Hacker, G. W., Dietze, O., and Wirl, G. (2001). Co-expression of tenascin-C and vimentin in human breast cancer cells indicates phenotypic transdifferentiation during tumour progression: Correlation with histopathological parameters, hormone receptors, and oncoproteins. J. Pathol. 193, 181-189.
8. Evans, S. S., Lee, D. B., Han, T., Tomasi, T. B., and Evans, R. L. (1990). Monoclonal antibody to the interferon-inducible protein Leu-13 triggers aggregation and inhibits proliferation of leukemic B cells. Blood 76, 2583-2593.
9. Fynan, T. M., and Reiss, M. (1993). Resistance to inhibition of cell growth by transforming growth factor- beta and its role in oncogenesis. Crit. Rev. Oncog. 4, 493-540.
10. Germolec, D. R., Spalding, J., Boorman, G. A., Wilmer, J. L., Yoshida, T., Simeonova, P. P., Bruccoleri, A., Kayama, F., Gaido, K., Tennant, R., et al. (1997). Arsenic can mediate skin neoplasia by chronic stimulation of keratinocyte-derived growth factors. Mut. Res. 386, 209-218.
11. Germolec, D. R., Spalding, J., Yu, H.-S., Chen, G. S., Simeonova, P. P., Humble, M. C., Bruccoleri, A., Boorman, G. A., Foley, J. F., Yoshida, T., et al. (1998). Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors. Am. J. Pathol. 153, 1775-1785.
12. Germolec, D. R., Yoshida, T., Gaido, K., Wilmer, J. L., Simeonova, P. P., Kayama, F., Burleson, F., Dong, W., Lang, R. W., and Luster, M. I. (1996). Arsenic induces overexpression of growth factors in human keratinocytes. Toxicol. Appl. Pharmacol. 141, 308-318.
13. Gille, J., and Swerlick, R. A. (1996). Integrins: Role in cell adhesion and communication. Ann. N.Y. Acad. Sci. 797, 93-106.
14. Glozak, M. A., and Rogers, M. B. (1996). Specific induction of apoptosis in P19 embryonal carcinoma cells by retinoic acid and BMP2 or BMP4. Dev. Biol. 179, 458-470.
15. Hamasuna, R., Kataoka, H., Meng, J. Y., Itoh, H., Moriyama, T., Wakisaka, S., and Koono, M. (2001). Reduced expression of hepatocyte growth factor activator inhibitor type- 2/placental bikunin (HAI-2/PB) in human glioblastomas: Implication for anti-invasive role of HAI-2/PB in glioblastoma cells. Int. J. Cancer 93, 339-345.
16. Harvat, B. L., and Jetten, A. M. (2001). Decreased growth inhibitory responses of squamous carcinoma cells to interferon-gamma involve failure to recruit cki proteins into cdk2 complexes. J. Invest. Dermatol. 117, 1274-1281.
17. Hellemans, G., Soumillion, A., Proost, P., Van Damme, J., Van Poppel, H., Baert, L., and De Ley, M. (1999). Metallothioneins in human kidneys and associated tumors. Nephron 83, 331-340.
18. Huang, J., DeGraves, F. J., Gao, D., Feng, P., Schlapp, T., and Kaltenboeck, B. (2001a). Quantitative detection of Chlamydia spp. by fluorescent PCR in the LightCycler. Biotechniques 30, 150-157. Huang, Q., Dunn, R. T., Jayadev, S., DiSorbo, O., Pack, F. D., Farr, S. B.
19. Stoll, R. E., and Blanchard, K. T. (2001b). Assessment of cisplatin-induced nephrotoxicity by microarray technology. Toxicol. Sci. 63, 196-207.
20. Jackets, P., Minoletti, F., Belotti, D., Clausse, N., Sozzi, G., Sobel, M. E., and Castronovo, V. (1996). Isolation from a multigene family of the active human gene of the metastasis-associated multifunctional protein 37LRP/p40 at chromosome 3p21.3. Oncogene 13, 495-503.
21. Jin, Y., Tipoe, G. L., Liong, E. C., Lau, T. Y., Fung, P. C., and Leung, K. M. (2001). Overexpression of BMP-2/4, -5 and BMPR-IA associated with malignancy of oral epithelium. Oral Oncol. 37, 225-233.
22. Lehmann, J. M., Riethmuller, G., and Johnson, J. P. (1989). MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. Proc. Natl. Acad. Sci. U.S.A. 86, 9891-9895.
23. Luca, M., Xie, S., Gutman, M., Huang, S., and Bar-Eli, M. (1995). Abnormalities in the CDKN2 (p16INK4/MTS-1) gene in human melanoma cells: Relevance to tumor growth and metastasis. Oncogene 11, 1399-1402.
24. Masutani, C., Sugasawa, K., Yanagisawa, J., Sonoyama, T., Ui, M., Enomoto, T., Takio, K., Tanaka, K., van der Spek, P. J., Bootsma, D., et al. (1994). Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. EMBO J. 13, 1831-1843.
25. Nakamura, T., Scorilas, A., Stephan, C., Yousef, G. M., Kristiansen, G., Jung, K., and Diamandis, E. P. (2003). Quantitative analysis of macrophage inhibitory cytokine-1 (MIC-1) gene expression in human prostatic tissues. Br. J. Cancer 88, 1101-1104.
26. Ng, J. C., Seawright, A. A., Qi, L., Garnett, C. M., Chiswell, B., and Moore, M. R. (1999). Tumors in mice induced by exposure to sodium arsenate in drinking water. In Arsenic Exposure and Health Effects (W. R. Chappell, C. O. Abernathy, and R. L. Calderon, Eds.), pp. 217-223. Elsevier Science, New York, NY.
27. Raingeaud, J., Whitmarsh, A. J., Barrett, T., Derijard, B., and Davis, R. J. (1996). MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell Biol. 16, 1247-1255.
28. Rajeevan, M. S., Vernon, S. D., Taysavang, N., and Unger, E. R. (2001). Validation of array-based gene expression profiles by real-time (kinetic) RT-PCR. J. Mol. Diagn. 3, 26-31.
29. Rhim, J. S., Jay, G., Arnstein, P., Price, F. M., Sanford, K. K., and Aaronson, S. A. (1985). Neoplastic transformation of human epidermal keratinocytes by AD12-SV40 and Kirsten sarcoma viruses. Science 227, 1250-1252.
30. Shultz, V. D., Phillips, S., Sar, M., Foster, P. M., and Gaido, K. W. (2001). Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate. Toxicol. Sci. 64, 233-242.
31. Solum, D. T., and Handa, R. J. (2002). Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus. J. Neurosci. 22, 2650-2659.
32. Thompson, L. H., Brookman, K. W., Jones, N. J., Allen, S. A., and Carrano, A. V. (1990). Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange. Mol. Cell. Biol. 10, 6160-6171.
33. Trask, D. K., Band, V., Zajchowski, D. A., Yaswen, P., Suh, T., and Sager, R. (1990). Keratins as markers that distinguish normal and tumor-derived mammary epithelial cells. Proc. Natl. Acad Sci. U.S.A. 87, 2319-2323.
34. Tseng, W. P., Chu, H. M., How, S. W., Fong, J. M., Lin, C. S., and Yeh, S. (1968). Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan. J. Natl. Cancer Inst. 40, 453-463.
35. Waters, K. M., Safe, S., and Gaido, K. W. (2001). Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice. Toxicol. Sci. 63, 47-56.
36. Welsh, J. B., Zarrinkar, P. P., Sapinoso, L. M., Kern, S. G., Behling, C. A., Monk, B. J., Lockhart, D. J., Burger, R. A., and Hampton, G. M. (2001). Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer. Proc. Natl. Acad. Sci. U.S.A. 98, 1176-1181.
37. Xu, X. X., Yang, W., Jackowski, S., and Rock, C. O. (1995). Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product. J. Biol. Chem. 270, 14184-14191.
38. Ye, J., Zhang, X., Young, H. A., Mao, Y., and Shi, X. (1995). Chromium(VI)-induced nuclear factor-kB activation in intact cells via free radical reactions. Carcinogenesis 16, 2401-2405.
39. Zhang, W., Ohnishi, K., Shigeno, K., Fujisawa, S., Naito, K., Nakamura, S., Takeshita, K., Takeshita, A., and Ohno, R. (1998). The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms. Leukemia 12, 1383-1391.