Activation of microglia with lipopolysaccharide leads to the prolonged decrease of conventional protein kinase C activity

Molecular Brain Research

Volumn 110, Issue 1, 2003, Pages 92-99

  Nakajima, Kazuyuki ^a,b   Kohsaka, Shinichi ^b   Tohyama, Yoko ^a   Kurihara, Tadashi ^a  

^a SOKA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Lipopolysaccharide; Microglia; Nitric oxide; Protein kinase C activity; Tumor necrosis factor

Indexed keywords

BISINDOLYLMALEIMIDE; INTERLEUKIN 1BETA; ISOENZYME; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOCYTOCHEMISTRY; INCUBATION TIME; MICROGLIA; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANIMALS; CARCINOGENS; CELLS, CULTURED; ENZYME INHIBITORS; IMMUNOHISTOCHEMISTRY; INDOLES; LIPOPOLYSACCHARIDES; MALEIMIDES; MICROGLIA; NITRIC OXIDE; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; RATS; TETRADECANOYLPHORBOL ACETATE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037474172     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(02)00644-7     Document Type: Article

References (42)

1. Banati R.B., Gehrmann J., Schubert P., Kreutzberg G.W. Cytotoxicity of microglia. Glia. 7:1993;111-118.
2. Benveniste E.N. Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action. Am. J. Physiol. 263:1992;C1-16.
3. Benveniste E.N., Huneycutt B.S., Shrikant P., Ballestas M.E. Second messenger systems in the regulation of cytokines and adhesion molecules in the central nervous system. Brain Behav. Immunol. 9:1995;304-314.
4. Boje K.M., Arora P.K. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res. 587:1992;250-256.
5. Chao C.C., Hu S. Tumor necrosis factor-α potentiates glutamate neurotoxicity in human fetal brain cell cultures. Dev. Neurosci. 16:1994;172-179.
6. Colton C.A., Snell J., Chernyshev O., Gilbert D.L. Induction of superoxide anion and nitric oxide production in cultured microglia. Ann. NY Acad. Sci. 738:1994;54-63.
7. Diks S.H., van Deventer S.J., Peppelenbosch M.P. Lipopolysaccharide recognition, internalisation, signalling and other cellular effects. J. Endotoxin Res. 7:2001;335-348.
8. Domanska-Janik K. Protein serine/threonine kinases (PKA, PKC and CaMKII) involved in ischemic brain pathology. Acta Neurobiol. Exp (Warsz.). 56:1996;579-585.
9. Downen M., Amaral T.D., Hua L.L., Zhao M.L., Lee S.C. Neuronal death in cytokine-activated primary human brain cell culture: role of tumor necrosis factor-α Glia. 28:1999;114-127.
10. el Khoury J., Hickman S.E., Thomas C.A., Cao L., Silverstein S.C., Loike J.D. Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils. Nature. 382:1996;716-719.
11. Fiebich B.L., Butcher R.D., Gebicke-Haerter P.J. Protein kinase C-mediated regulation of inducible nitric oxide synthase expression in cultured microglial cells. J. Neuroimmunol. 92:1998;170-178.
12. Goodwin J.L., Uemura E., Cunnick J.E. Microglial release of nitric oxide by the synergistic action of β-amyloid and IFN-γ Brain Res. 692:1995;207-214.
13. Grau V., Herbst B., van der Meide P.H., Steiniger B. Activation of microglial and endothelial cells in the rat brain after treatment with interferon-γ in vivo. Glia. 19:1997;181-189.
14. Imai Y., Ibata I., Ito D., Ohsawa K., Kohsaka S. A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochem. Biophys. Res. Commun. 224:1996;855-862.
15. Klegeris A., Walker D.G., McGeer P.L. Interaction of Alzheimer β-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-α Brain Res. 747:1997;114-121.
16. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19:1996;312-318.
17. Lees G.J. The possible contribution of microglia and macrophages to delayed neuronal death after ischemia. J. Neurol. Sci. 114:1993;119-122.
18. Lindner D., Gschwendt M., Marks F. Down-regulation of protein kinase C in Swiss 3T3 fibroblasts is independent of its phosphorylating activity. Biochem. Biophys. Res. Commun. 176:1991;1227-1231.
19. Lowry O.J., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
20. McDonald D.R., Brunden K.R., Landreth G.E. Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. J. Neurosci. 17:1997;2284-2294.
21. McMillian M.K., Vainio P.J., Tuominen R.K. Role of protein kinase C in microglia-induced neurotoxicity in mesencephalic cultures. J. Neuropathol. Exp. Neurol. 56:1997;301-307.
22. Meda L., Cassatella M.A., Szendrei G.I., Otvos L. Jr., Baron P., Villalba M., Ferrari D., Rossi F. Activation of microglial cells by β-amyloid protein and interferon-γ Nature. 374:1995;647-650.
23. Merrill J.E. Effects of interleukin-1 and tumor necrosis factor-α on astrocytes, microglia, oligodendrocytes, and glial precursors in vitro. Dev. Neurosci. 13:1991;130-137.
24. Nakai M., Hojo K., Yagi K., Saito N., Taniguchi T., Terashima A., Kawamata T., Hashimoto T., Maeda K., Gschwendt M., Yamamoto H., Miyamoto E., Tanaka C. Amyloid β protein (25-35) phosphorylates MARCKS through tyrosine kinase-activated protein kinase C signaling pathway in microglia. J. Neurochem. 72:1999;1179-1186.
25. Nakajima K., Honda S., Tohyama Y., Imai Y., Kohsaka S., Kurihara T. Neurotrophin secretion from cultured microglia. J. Neurosci. Res. 65:2001;322-331.
26. Nakajima K., Honda S., Tohyama Y., Kurihara T., Kohsaka S. Ceramide-enhanced urokinase-type plasminogen activator (uPA) release is mediated by protein kinase C in cultured microglia. Glia. 32:2000;226-233.
27. Nakajima K., Kikuchi Y., Ikoma E., Honda S., Ishikawa M., Liu Y., Kohsaka S. Neurotrophins regulate the function of cultured microglia. Glia. 24:1998;272-289.
28. Nakajima K., Kohsaka S. Microglia: activation and their significance in the central nervous system. J. Biochem (Tokyo). 130:2001;169-175.
29. Nakajima K., Shimojo M., Hamanoue M., Ishiura S., Sugita H., Kohsaka S. Identification of elastase as a secretory protease from cultured rat microglia. J. Neurochem. 58:1992;1401-1408.
30. Nakamura Y., Si Q., Kataoka K. Lipopolysaccharide-induced microglial activation in culture: temporal profiles of morphological change and release of cytokines and nitric oxide. Neurosci. Res. 35:1999;95-100.
31. Nakamura Y., Si Q., Kataoka K. Differential regulation of microglial NO production by protein kinase C inhibitors. Neurochem. Int. 38:2001;1-7.
32. Nishizuka Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9:1995;484-496.
33. Padmaperuma B., Mark R., Dhillon H.S., Mattson M.P., Prasad M.R. Alterations in brain protein kinase C after experimental brain injury. Brain Res. 714:1996;19-26.
34. Reith M.E., Xu C., Chen N.H. Pharmacology and regulation of the neuronal dopamine transporter. Eur. J. Pharmacol. 324:1997;1-10.
35. Sastry P.S., Rao K.S. Apoptosis and the nervous system. J. Neurochem. 74:2000;1-20.
36. Savolainen K.M., Loikkanen J., Eerikainen S., Naarala J. Glutamate-stimulated ROS production in neuronal cultures: interactions with lead and the cholinergic system. Neurotoxicology. 19:1998;669-674.
37. Selmaj K.W., Raine C.S. Tumor necrosis factor mediate myelin and oligodendrocyte damage in vitro. Ann. Neurol. 23:1988;339-346.
38. Smith M.E., van der Maesen K., Somera F.P., Sobel R.A. Effects of phorbol myristate acetate (PMA) on functions of macrophages and microglia in vitro. Neurochem. Res. 23:1998;427-434.
39. Sortino M.A., Condorelli F., Vancheri C., Canonico P.L. Tumor necrosis factor-α induces apoptosis in immortalized hypothalamic neurons: involvement of ceramide-generating pathways. Endocrinology. 140:1999;4841-4849.
40. Yang K., Taft W.C., Dixon C.E., Todaro C.A., Yu R.K., Hayes R.L. Alterations of protein kinase C in rat hippocampus following traumatic brain injury. J. Neurotrauma. 10:1993;287-295.
41. M. Yogev-Falach, T. Amit, O. Bar-Am, M. Weinstock, M.B. Youdim, The involvement of mitogen-activated protein (MAP) kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline. FASEB J. (2002) in press.
42. Zielasek J., Hartung H.P. Molecular mechanisms of microglial activation. Adv. Neuroimmunol. 6:1996;191-202.