Development and validation of a gas chromatographic-mass spectrometric method for simultaneous identification and quantification of marker compounds including bilobalide, ginkgolides and flavonoids in Ginkgo biloba L. extract and pharmaceutical preparations

Journal of Chromatography A

Volumn 986, Issue 1, 2003, Pages 121-127

  Deng, Fengxia ^a   Zito, S William ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

Bilobalide; Flavonoids; Ginkgo biloba L.; Ginkgolides

Indexed keywords

GAS CHROMATOGRAPHY; MASS SPECTROMETRY; PIGMENTS;

CHEMICAL MARKERS;

DRUG PRODUCTS;

BILOBALIDE; FLAVONOID; GINKGO BILOBA EXTRACT; GINKGOLIDE; GINKGOLIDE A; GINKGOLIDE B; GINKGOLIDE C; ISORHAMNETIN; KAEMPFEROL; MARKER; QUERCETIN; TERPENOID;

ANALYTIC METHOD; ARTICLE; CALIBRATION; DRUG CAPSULE; DRUG IDENTIFICATION; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACEUTICS; PRIORITY JOURNAL; PRODUCT RECOVERY; QUANTITATIVE ANALYSIS; STANDARDIZATION; VALIDATION PROCESS;

CALIBRATION; CYCLOPENTANES; DITERPENES; FLAVONOIDS; FURANS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GINKGO BILOBA; GINKGOLIDES; LACTONES; PHARMACEUTICAL PREPARATIONS; PLANT EXTRACTS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

GINKGO BILOBA;

EID: 0037473927     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(02)01921-0     Document Type: Article

References (10)

1. Blumenthal M. HerbalGram. 51:2001;69.
2. Blumenthal M. The Complete German Commission E Monographs. 1998;Integrative Medicine Communications, Boston, MA. Ch. 1, p. 136.
3. Kressmann S., Müller W.E., Blume H.H. J. Pharm. Pharmacol. 54:2002;661.
4. Sticher O. Planta Med. 59:1993;2.
5. van Beek T.A. J. Chromatogr. A. 967:2002;21.
6. Lang Q., Yak H.K., Wai C.M. Talanta. 54:2001;673.
7. Lang Q., Wai C.M. Anal. Chem. 71:1999;2929.
8. United States Pharmacopeia, 24th review and National Formulary, 19th ed. (USP 24-NF19), Rockville, MD, 1999, p. 2458.
9. Chin L., Lin Y.R., Huang C.Y., Wen K.C. J. Food Drug Anal. 8:2000;289.
10. Braquet P. Braquet P. Ginkgolides: Chemistry, Biology, Pharmacology and Clinical Perspectives. Vol. 1:1988;XIX J.R. Prous Science Publishers, Barcelona.