Non-parametric estimators of a monotonic dose-response curve and bootstrap confidence intervals

Statistics in Medicine

Volumn 22, Issue 6, 2003, Pages 869-882

  Dilleen, Maria ^a   Heimann, Günter ^a   Hirsch, Ian ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Bootstrap confidence intervals; Isotonic regression estimator; Monotonic dose response; Restricted least squares estimator

Indexed keywords

NEW DRUG; PLACEBO;

ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DOSE RESPONSE; EMPIRICISM; LINEAR SYSTEM; PHARMACOLOGICAL PARAMETERS; REGRESSION ANALYSIS; SAMPLE SIZE; SIMULATION; STANDARD; STATISTICAL ANALYSIS;

COMPUTER SIMULATION; CONFIDENCE INTERVALS; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LEAST-SQUARES ANALYSIS; MODELS, STATISTICAL; RANDOMIZED CONTROLLED TRIALS; SAMPLE SIZE; THERAPEUTIC EQUIVALENCY;

EID: 0037473221     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/sim.1460     Document Type: Article

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