Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase α reveals multiple alternative splicing and functional diversity

Gene

Volumn 304, Issue 1-2, 2003, Pages 107-115

  Tan, Ivan ^a   Cheong, Albert ^a   Lim, Louis ^a,b   Leung, Thomas ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Alternative splicing; Cdc42; Cdc42 Rac interactive binding domain; Cytoskeleton; Genomic organization; Myotonic dystrophy kinase related Cdc42 binding kinase; Rac

Indexed keywords

COMPLEMENTARY DNA; GUANOSINE TRIPHOSPHATASE; MYOTONIC DYSTROPHY KINASE RELATED CDC42 BINDING KINASE ALPHA; PHOSPHOTRANSFERASE; RNA; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CATALYSIS; CHROMOSOMAL LOCALIZATION; CHROMOSOME 1Q; CONTROLLED STUDY; DNA SEQUENCE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; EXON; GENE CONTROL; GENE FUNCTION; GENE LOCATION; GENE STRUCTURE; GENETIC CONSERVATION; GENETIC ORGANIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN VARIABLE REGION; MYOTONIC DYSTROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN VARIANT; RAT; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0037472694     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(02)01185-X     Document Type: Article

References (36)

1. Amano M., Chihara K., Nakamura N., Kaneko T., Matsuura Y., Kaibuchi K. The COOH terminus of Rho-kinase negatively regulates rho-kinase activity. J. Biol. Chem. 274:1999;32418-32424.
2. Aslanidis C., Jansen G., Amemiya C., et al. Cloning of the essential myotonic dystrophy region and mapping of the putative defect. Nature. 355:1992;548-551.
3. Bishop A.L., Hall A. Rho GTPases and their effector proteins. Biochem. J. 348:(2):2000;241-255.
4. Burbelo P.D., Drechsel D., Hall A. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J. Biol. Chem. 270:1995;29071-29074.
5. Bush E.W., Helmke S.M., Birnbaum R.A., Perryman M.B. Myotonic dystrophy protein kinase domains mediate localization, oligomerization, novel catalytic activity, and autoinhibition. Biochemistry. 39:2000;8480-8490.
6. Chen X.Q., Tan I., Leung T., Lim L. The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cells. J. Biol. Chem. 274:1999;19901-19905.
7. Chen X.Q., Tan I., Ng C.H., Hall C., Lim L., Leung T. Characterization of RhoA-binding kinase ROKalpha-implication of the pleckstrin homology domain in ROKalpha function using region-specific antibodies. J. Biol. Chem. 277:2002;12680-12688.
8. Di Cunto F., Calautti E., Hsiao J., Ong L., Topley G., Turco E., Dotto G.P. Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron. J. Biol. Chem. 273:1998;29706-29711.
9. Di Cunto F., Imarisio S., Hirsch E., Broccoli V., Bulfone A., Migheli A., Atzori C., Turco E., Triolo R., Dotto G.P., Silengo L., Altruda F. Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis. Neuron. 28:2000;115-127.
10. Eda M., Yonemura S., Kato T., Watanabe N., Ishizaki T., Madaule P., Narumiya S. Rho-dependent transfer of Citron-kinase to the cleavage furrow of dividing cells. J. Cell Sci. 114:2001;3273-3284.
11. Fushman D., Najmabadi-Haske T., Cahill S., Zheng J., LeVine H. 3rd, Cowburn D. The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits. J. Biol. Chem. 273:1998;2835-2843.
12. rac derived by alternate splicing of the human n-chimaerin gene, is selectively expressed in brain regions and testes. Mol. Cell. Biol. 13:1993;4986-4998.
13. Hara T., Chida K. Genomic organization and chromosomal localization of the mouse protein kinase Calpha gene. Gene. 291:2002;11-16.
14. Ishizaki T., Maekawa M., Fujisawa K., Okawa K., Iwamatsu A., Fujita A., Watanabe N., Saito Y., Kakizuka A., Morii N., Narumiya S. The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J. 15:1996;1885-1893.
15. Joberty G., Perlungher R.R., Macara I.G. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol. Cell. Biol. 19:1999;6585-6597.
16. Kimura K., Ito M., Amano M., Chihara K., Fukata Y., Nakafuku M., Yamamori B., Feng J., Nakano T., Okawa K., Iwamatsu A., Kaibuchi K. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science. 273:1996;245-248.
17. Kozma R., Ahmed S., Best A., Lim L. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell. Biol. 15:1995;1942-1952.
18. Lemmon M.A., Ferguson K.M. Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem. J. 350:(1):2000;1-18.
19. Leung T., Chen X.Q., Manser E., Lim L. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol. Cell. Biol. 16:1996;5313-5327.
20. Leung T., Chen X.Q., Tan I., Manser E., Lim L. Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization. Mol. Cell. Biol. 18:1998;130-140.
21. Lim L., Manser E., Leung T., Hall C. Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways. Eur. J. Biochem. 242:1996;171-185.
22. Luo L., Lee T., Tsai L., Tang G., Jan L.Y., Jan Y.N. Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization. Proc. Natl. Acad. Sci. USA. 94:1997;12963-12968.
23. Manser E., Leung T., Salihuddin H., Tan L., Lim L. A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. Nature. 363:1993;364-367.
24. Matsui T., Amano M., Yamamoto T., Chihara K., Nakafuku M., Ito M., Nakano T., Okawa K., Iwamatsu A., Kaibuchi K. Rho-associated kinas, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J. 15:1996;2208-2216.
25. Moncrieff C.L., Bailey M.E., Morrison N., Johnson K.J. Cloning and chromosomal localization of human Cdc42-binding protein kinase beta. Genomics. 57:1999;297-300.
26. Muranyi A., Zhang R., Liu F., Hirano K., Ito M., Epstein H.F., Hartshorne D.J. Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity. FEBS Lett. 493:2001;80-84.
27. Pirone D.M., Carter D.E., Burbelo P.D. Evolutionary expansion of CRIB-containing Cdc42 effector proteins. Trends Genet. 17:2001;370-373.
28. Postma F.R., Jalink K., Hengeveld T., Moolenaar W.H. Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor. EMBO J. 15:1996;2388-2392.
29. Ridley A.J., Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 70:1992;389-399.
30. Rothe M., Pehl M., Taubert H., Jackle H. Loss of gene function through rapid mitotic cycles in the Drosophila embryo. Nature. 359:1992;156-159.
31. Shaw D.J., McCurrach M., Rundle S.A., et al. Genomic organization and transcriptional units at the myotonic dystrophy locus. Genomics. 18:1993;673-679.
32. Sumi T., Matsumoto K., Shibuya A., Nakamura T. Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. J. Biol. Chem. 276:2001;23092-23096.
33. Tan I., Ng C.H., Lim L., Leung T. Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. J. Biol. Chem. 276:2001;21209-21216.
34. Tan I., Seow K.T., Lim L., Leung T. Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha. Mol. Cell. Biol. 21:2001;2767-2778.
35. Venter J.C., Adams M.D., Myers E.W., et al. The sequence of the human genome. Science. 291:2001;1304-1351.
36. Zhao Y., Loyer P., Li H., Valentine V., Kidd V., Kraft A.S. Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases. J. Biol. Chem. 272:1997;10013-10020.