Improvement by repeated administration of 6R-tetrahydrobiopterin of 5,7-dihydroxytryptamine-induced abnormal behaviors in immature rats

Biochemical and Biophysical Research Communications

Volumn 302, Issue 1, 2003, Pages 156-161

  Mizuma, Hiroshi ^a   Mizutani, Mika ^a   Nozaki, Satoshi ^b   Iizuka, Hirohito ^a   Tohyama, Hideo ^a   Nishimura, Nobuhiro ^a   Watanabe, Yasuyoshi ^b   Kohashi, Ryuichiro ^a  

^a KYORIN UNIVERSITY   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

5 HT turnover ratio; 6R L Erythro 5,6,7,8 tetrahydrobiopterin (6R BH4); Locomotion activity; Open field test; Rat; Serotonin (5 HT)

Indexed keywords

5,7 DIHYDROXYTRYPTAMINE; 6 ERYTHRO 5,6,7,8 TETRAHYDROBIOPTERIN; BIOPTERIN; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN CORTEX; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; DRUG EFFECT; DRUG INDUCED DISEASE; DRUG MECHANISM; FEMALE; LOCOMOTION; MULTIPLE DRUG DOSE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN BRAIN LEVEL;

EID: 0037470524     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00128-1     Document Type: Article

References (21)

1. Kaufman S. Tetrahydrobiopterin: Basic Biochemistry and Role in Human Disease. 1997;The John Hopkins University Press, Baltimore.
2. Miwa S., Watanabe Y., Hayaishi O. 6R-L-erythro-5,6,7,8,-tetrahydrobiopterin tetrahydrobiopterin as a regulator of dopamine and serotonin biosynthesis in the rat brain. Arch. Biochem. Biophys. 239:1985;234-241.
3. Collier J., Vallance P. Second messenger role for NO widens to nervous and immune systems. Trends Pharmacol. Sci. 10:1989;427-431.
4. Koshimura K., Miwa S., Lee K., Fujiwara M., Watanabe Y. Enhancement of dopamine release in vivo from rat striatum by dialytic perfusion of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin. J. Neurochem. 54:1990;1391-1397.
5. Mataga N., Imamura K., Watanabe Y. 6R-tetrahydrobiopterin perfusion enhances dopamine, serotonin, and glutamate outputs in dialysate from rat striatum and frontal cortex. Brain Res. 551:1991;64-71.
6. Kaufman S., Kapatos G., Mclnnes R.R., Schulman J.D., Rizzo W.B. Use of tetrahydropterins in the treatment of hyperphenylalaninemia due to defective synthesis of tetrahydrobiopterin: evidence that peripherally administered tetrahydropterins enter the brain. Pediatrics. 70:1982;376-380.
7. Curtius H.C., Niederwieser A., Levine R.A., Mulder H. Therapeutic efficacy of tetrahydrobiopterin in Parkinson's disease. Hassler R.G., Christ J.F. Parkinson-Specific Motor and Mental Disorders Vol. 40: Advances in Neurology. 1984;463-466 Raven Press, New York.
8. Curtius H.C., Niederwieser A., Levine R.A., Lovenberg W., Woggon B., Angst J. Successful treatment of depression with tetrahydrobiopterin. Lancet. 1:1983;657-658.
9. Lewitt P.A., Miller L.P., Levine R.A., Lovenberg W., Newman R.P., Papavasilou A., Rayes A., Eldrige R., Burns R.S. Tetrahydrobiopterin in dystonia: identification of abnormal metabolism and therapeutic trials. Neurology. 36:1986;760-764.
10. Naruse H., Hayashi T., Takesada M., Nakane A., Yamazaki K., Noguchi T., Watanabe Y., Hayaishi O. Therapeutic effect of tetrahydrobiopterin in infantile autism. Proc. Jpn. Acad. Ser. B. 63:1987;231-233.
11. 11C ]DOPA turnover in the rat striatum with infusion of L-tyrosine J. Neural Transm. 95:1994;1-15.
12. Tani Y., Ishihara T., Kanai T., Ohno T., Andersson J., Lilja A., Antoni G., Fasth K.J., Bjurling P., Westerberg G., Hartvig P., Onoe H., Watanabe Y., Längström B. Effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on the dopamine and cholinergic receptors as evaluated by positron emission tomography in the rhesus monkey. J. Neural Transm. 102:1995;189-208.
13. 2 receptors in rat brain Biochem. Biophys. Res. Commun. 227:1996;794-799.
14. Mercugliano M., Nguyen H., Djali S., Lucki I. Developmental alterations in 5-hydroxytryptamine concentration and turnover after treatment of neonatal rats with 5,7-dihydroxytryptamine. Neurobiol. Learn. Mem. 65:1996;163-176.
15. Pranzatelli M.R., Dollison A.M., Hibczuk V. Intracisternal 5,7-dihydroxytryptamine lesions in neonatal and adult rats: comparison of response to 5-hydroxytryptophan. Dev. Neurosci. 11:1989;205-211.
16. Turlejski K., Djavadian R.L., Kossut M. Neonatal serotonin depletion modifies development but not plasticity in rat barrel cortex. Neuroreport. 8:1997;1823-1828.
17. Tani Y., Ohno T. Analysis of 6R- and 6S-tetrahydrobiopterin and other pterins by reversed-phase ion-pair liquid chromatography with fluorimetric detection by post-column sodium nitrite oxidation. J. Chromatogr. 617:1993;249-255.
18. Lucot J.B., Seiden L.S. Effects of neonatal administration of 5,7-dihydroxytryptamine on locomotor activity. Psychopharmacology (Berl.). 77:1982;114-116.
19. Breese G.R., Cooper B.R. Behavioral and biochemical interactions of 5,7-dihydroxytryptamine with various drugs when administered intracisternally to adult and developing rats. Brain Res. 98:1975;517-527.
20. Fischette C.T., Nock B., Renner K. Effects of 5,7-dihydroxy-tryptamine on serotonin1 and serotonin2 receptors throughout the rat central nervous system using quantitative autoradiography. Brain Res. 421:1987;263-279.
21. 1A binding sites in rats with chronic neonatal 5,7-dihydroxytryptamine lesions Dev. Brain Res. 80:1994;1-6.