Effects of alkali and simulated gastric and intestinal fluids on danazol stability

Journal of Pharmaceutical and Biomedical Analysis

Volumn 31, Issue 4, 2003, Pages 743-751

  Gadkariem, E A ^a   El Obeid, H A ^a   Abounassif, M A ^a   Ahmed, S M ^a   Ibrahim, K E E ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b UNIVERSITY OF KHARTOUM   (Sudan)

Author keywords

Base catalysis; Danazol; Degradation product; HPLC

Indexed keywords

ACETIC ACID; ALKALI; BORIC ACID; DANAZOL; METHANOL; PHOSPHATE; SODIUM HYDROXIDE;

ALKALINITY; AQUEOUS SOLUTION; ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; DRUG ACTIVATION; DRUG DECOMPOSITION; DRUG DEGRADATION; DRUG HYDROLYSIS; DRUG IDENTIFICATION; DRUG OXIDATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED RADIATION; INTESTINE FLUID; IONIC STRENGTH; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PH; PRIORITY JOURNAL; SIMULATION; STOMACH JUICE; TEMPERATURE DEPENDENCE;

EID: 0037467217     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(02)00660-X     Document Type: Article

References (6)

1. Reynods J.E.F. Martindale, The Extra Pharmacopoeia. 31st ed. 1996;1488 Royal Pharmaceutical Society, London.
2. Gadkariem E.A., Abounassif M.A., Hagga M.E., Al-Khamees H.A. Photodegradation kinetic study and stability-indicating assay of danazol using high performance liquid chromatography. J. Pharm. Biomed. Anal. 23:2000;413-420.
3. Heyrovsky J., Zuman P. Practical Polarography, An introduction for Chemistry Students. 1968;179 Academic Press, London and New York.
4. The United States Pharmacopoeia XXIII and National Formulary XVIII. The US Pharmacopoeial Convention, Rockville, MD, 1995, pp. 452-453.
5. J.T. Carstensen (Ed.), Drug Stability: Principles and Practices, Marcel Dekker Inc, New York and Basel, 1995, pp. 1-16; pp. 18; pp. 83; pp. 91.
6. Fung L.H. Banker G.S., Chodes C.T. Modern Pharmaceutics. 1990;225 Marcel Dekker, New York.