Dopamine D1 receptor agonists induce penile erections in rats

European Journal of Pharmacology

Volumn 460, Issue 1, 2003, Pages 71-74

  D'Aquila, Paolo S ^a   Panin, Francesca ^a   Cossu, Maria ^a   Peana, Alessandra T ^a   Serra, Gino ^a  

^a UNIVERSITY OF SASSARI   (Italy)

Author keywords

Dopamine D1 like receptor agonist; Erectile dysfunction; Penile erection

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 3 (1 ADAMANTYL) 1 AMINOMETHYL 3,4 DIHYDRO 5,6 DIHYDROXY 1H 2 BENZOPYRAN; 4,6,6A,7,8,12B HEXAHYDRO 7 METHYLINDOLO[4,3 AB]PHENANTHRIDINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE 1 RECEPTOR BLOCKING AGENT; DOPAMINE 1 RECEPTOR STIMULATING AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ERECTILE DYSFUNCTION; MALE; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RAT;

EID: 0037466837     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)02881-9     Document Type: Article

References (29)

1. Altwein J.E., Keuler F.U. Oral treatment of erectile dysfunction with apomorphine SL. Urol. Int. 67:2001;257-263.
2. Argiolas A., Melis M.R., Mauri A., Gessa G.L. Paraventricular nucleus lesion prevents yawning and penile erection induced by apomorphine and oxytocin but not by ACTH in rats. Brain Res. 421:1987;349-352.
3. Baraldi M., Benassi-Benelli A. Induzione di erezioni ripetute nel ratto adulto mediante apomorfina. Riv. Farmacol. Ter. 6:1975;147-149.
4. Dehpour A.R., Samini M., Sharifzadeh M., Hasan-Mazandarani H. Effects of chronic lithium pretreatment on apomorphine-induced penile erection. Gen. Pharmacol. 26:1995;1015-1020.
5. Doherty P.C., Wisler P.A. Stimulatory effects of quinelorane on yawning and penile erection in the rat. Life Sci. 54:1994;507-514.
6. Fagan T.C., Buttler S., Marbury T., Taylor A., Edmonds A. Cardiovascular safety of sublingual apomorphine in patients on stable doses of oral antihypertensive agents and nitrates. Am. J. Cardiol. 88:2001;760-766.
7. Fenu S., Acquas E., Di Chiara G. Role of striatal acetylcholine on dopamine D1 receptor agonist-induced turning behavior in 6-hydroxydopamine lesioned rats: a microdialysis-behavioral study. Neurol. Sci. 22:2001;63-64.
8. Ferrari F., Giuliani D. Behavioural effects induced in rats and chicks by D2 dopamine agonists. Physiol. Behav. 54:1993;695-700.
9. Ferrari F., Giuliani D. Involvement of dopamine D2 receptors in the effect of cocaine on sexual behaviour and stretching-yawning of male rats. Neuropharmacology. 36:1997;769-777.
10. Ferrari F., Pelloni F., Giuliani D. Behavioural evidence that different neurochemical mechanisms underlie stretching yawning and penile erection induced in male rats by SND 919, a new selective D2 dopamine receptor agonist. Psychopharmacology. 113:1993;172-176.
11. Foote R.W., Buscher H.H., Romer D., Maurer R., Enz A., Gahwiler B.H., Shearman M.P., Wuntrich H. CY 208-243: a unique combination of atypical opioid antinociception and dopaminomimetic properties. Life Sci. 42:1988;137-152.
12. Heaton J.P., Morales A., Adams M.A., Johnston B., El-Rashidy R. Recovery of erectile function by the oral administration of apomorphine. Urology. 45:1995;200-206.
13. Hull E.M. Dopaminergic influences on male rat sexual behavior. Micevych P.E., Hammer R. Neurobiological Effects of Sex Steroid Hormones. 1995;234-253 University Press, Cambridge.
14. Hull E.M., Eaton R.C., Markowski V.P., Moses J., Lumley L.A., Loucks J.A. Opposite influence of medial preoptic D1 and D2 receptors on genital reflexes: implication for copulation. Life Sci. 51:1993;1705-1713.
15. Iorio L.C., Barnett A., Leitz F.H., Houser V.P., Korduba C.A. SCH 23390 a potential benzazepine antipsychotic with unique interactions on dopaminergic systems. J. Pharmacol. Exp. Ther. 226:1983;462-468.
16. Kebabian J.W., Britton D.R., De Ninno M.P., Perner R., Smith L., Jenner P., Schoenleber R., Williams M. "A 77636": a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur. J. Pharmacol. 229:1992;203-209.
17. Markstein R., Seiler M.P., Vigouret J.M., Urwyler S., Enz A., Dixon K. Pharmacologic properties of CY 208-243: a novel D1 agonist. Progress in Catecholamine Research: Part B. Central Aspects. 1988;59-64 Alan R. Liss, New York.
18. Melis M.R., Argiolas A. Dopamine and sexual behavior. Neurosci. Biobehav. Rev. 19:1999;19-38.
19. Melis M.R., Argiolas A., Gessa G.L. Apomorphine-induced penile erection and yawning: site of action on the brain. Brain Res. 415:1987;98-104.
20. Mulhall J.P., Bukofzer S., Edmonds A.L., George M. An open-label, uncontrolled dose-optimization study of sublingual apomorphine in erectile dysfunction. Clin. Ther. 23:2001;1260-1271.
21. Padma-Nathan H., Auerbach S., Lewis R., Lewand M., Perdok R. The apomorphine study group. Efficacy and safety of apomorphine SL vs. placebo for male erectile dysfunction. J. Urol. 161:1999;S214.
22. Pehek E.A., Thompson J.T., Hull E.M. The effects of intracranial administration of the dopamine agonists apomorphine on penile reflexes and seminal emission in the rat. Brain Res. 500:1989;325-332.
23. 1C receptor agonists produce reciprocal effects on behavior of rhesus monkeys. Eur. J. Pharmacol. 243:1993;227-234.
24. 1A receptor. Brain Res. 821:1999;414-425.
25. 1 DA agonist, induces penile erection in rats. Pharmacol. Res. Commun. 20:1988;247-248.
26. Setler P.E., Sarau H.M., Zirkle C.L., Saunders H.L. The central effects of a novel dopamine agonist. Eur. J. Pharmacol. 50:1978;419-430.
27. Von Keitz A.T., Stroberg P., Bukofzer S., Mallard N., Hibberd M. A European multicentre study to evaluate the tolerability of apomorphine sublingual administered in a forced dose-escalation regimen in patients with erectile dysfunction. BJU Int. 89:2002;409-415.
28. Wirtshafter D., Asin K.E. Comparative effects of scopolamine and quinpirole on the striatal fos expression induced by stimulation of D1 dopamine receptors in the rat. Brain Res. 893:2001;202-214.
29. Zarrindast M.R., Shokravi S., Samini M. Opposite influences of dopaminergic receptor subtypes on penile erection. Gen. Pharmacol. 23:1992;671-675.