Practical approach for the stability testing of veterinary drugs in solutions and in biological matrices during storage

Analytica Chimica Acta

Volumn 483, Issue 1-2, 2003, Pages 419-427

  Croubels, Siska ^a   De Baere, Siegrid ^a   De Backer, Patrick ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

4 Epioxytetracycline; Amoxycillin; Clindamycin; Closantel; High performance liquid chromatography with ultraviolet detection (HPLC UV); Ketoprofen; Matrix; Oxytetracycline; Solution; Stability; Storage; Sulfachloropyridazin; Sulfadiazine; Trimethoprim; Tylosin A

Indexed keywords

ANTIBIOTICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SOLVENTS; STABILITY; STORAGE (MATERIALS); TISSUE; ULTRAVIOLET SPECTROMETERS;

BIOLOGICAL MATRICES;

VETERINARY MEDICINE;

4 EPIOXYTETRACYCLINE; AMOXICILLIN; ANTHELMINTIC AGENT; ANTIBIOTIC AGENT; CLINDAMYCIN; CLOSANTEL; DOXYCYCLINE; KETOPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; OXYTETRACYCLINE; SULFACHLORPYRIDAZINE; SULFADIAZINE; SULFONAMIDE; TRIMETHOPRIM; TYLOSIN; UNCLASSIFIED DRUG; VETERINARY DRUG;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CHICKEN; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG SCREENING; DRUG SOLUTION; DRUG STABILITY; DRUG STORAGE; DRUG TISSUE LEVEL; LIQUID CHROMATOGRAPHY; NONHUMAN; PLASMA; PRIORITY JOURNAL; SAMPLE; STANDARD; SWINE; TANDEM MASS SPECTROMETRY; TEMPERATURE; TISSUE; ULTRAVIOLET RADIATION;

ANIMALS; DRUGS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; SOLVENTS; STABILITY; STORAGE; TISSUE;

ANIMALIA; SUS SCROFA;

EID: 0037466579     PISSN: 00032670     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2670(02)01479-4     Document Type: Article

References (9)

1. Commission Decision laying down analytical methods to be used for detecting certain substances and residues thereof in live animal and animal products according to Council Directive 96/23/EC (Revision of Commission Decision 93/256/EC), European Commission, Directorate General for Agriculture VIBII2, SANCO/1805/2000.
2. Notice to Applicants, Veterinary Medicinal Products: Establishment of Maximum Residue Limits (MRLs) for Residues of Veterinary Products in Foodstuffs of Animal Origin: Development and Validation of a Proposed Regulatory Method, vol. 8, The European Agency for the Evaluation of Medicinal Products, EMEA/CVMP/573/00-FINAL, London.
3. J.O. Boison, in: H. Oka, H. Nakazawa, K.-I. Harada, J.D. MacNeil (Eds.), Chemical Analysis for Antibiotics Used in Agriculture, AOAC International, Arlington, VA, 1995, p. 254.
4. Cherlet M., Croubels S., De Backer P. J. Mass Spectrom. 37:2002;848.
5. M. Cherlet, S. De Baere, S. Croubels, P. De Backer, Anal. Chim. Acta 2002, in press.
6. De Baere S., Cherlet M., Baert K., De Backer P. Anal. Chem. 74:2002;1393.
7. Croubels S.M., Vanoosthuyze K.E.I., Van Peteghem C.H. J. Chromatogr. B. 690:1997;173.
8. Baert K., Croubels S., Gasthuys F., De Busser J., De Backer P. J. Vet. Pharmacol. Therap. 23:2000;45.
9. De Baere S., Baert K., Croubels S., De Busser J., De Wasch K., De Backer P. Analyst. 125:2000;409.