Complementary use of ion trap/time-of-flight mass spectrometry in combination with capillary high-pressure liquid chromatography: Early characterization of in vivo metabolites of the cathepsin K inhibitor NVP-AAV490 in rat

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 787, Issue 2, 2003, Pages 255-270

  Blum, Wolfgang ^a   Buhl, Thomas ^a   Altmann, Eva ^a   Kühnöl, Jürgen ^a   Ramstein, Philippe ^a   Aichholz, Reiner ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Cathepsin K inhibitor; NVP AAV490 NX

Indexed keywords

BONE; CHEMICAL MODIFICATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PATIENT TREATMENT;

OSTEOPOROSIS;

PROTEINS;

1 (2 CHLOROPHENYL) 1H 1,2,4 TRIAZOLE 3 CARBOXYLIC ACID [1 [2 (4 METHOXYPHENYLAMINO)ETHYLCARBAMOYL] 3 METHYLBUTYL]AMIDE; CATHEPSIN K; CYSTEINE PROTEINASE INHIBITOR; DEUTERIUM OXIDE; DRUG METABOLITE; HYDROGEN; ION; NVP AAV490; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATOM; CAPILLARY CHROMATOGRAPHY; CHEMICAL COMPOSITION; CHEMICAL MODIFICATION; CONJUGATION; CONTROLLED STUDY; DEVICE; DRUG DETERMINATION; DRUG METABOLISM; DRUG STRUCTURE; FEMALE; IN VIVO STUDY; LIVER HOMOGENATE; MASS SPECTROMETER; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS;

EID: 0037466190     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(02)00782-1     Document Type: Article

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